Quality standards for preclinical research in cardio-oncology
Abstract
Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investigate the mechanisms of CTR-CVT is often based on personal experience and opinion, rather than on established principles and available evidence. Moreover, presentation of methods and results is frequently approximate. This Scientific Statement outlines potential quality standards regarding methodology and reporting in preclinical cardio-oncology research, with the goal of promoting accurate, reliable, and reproducible studies. Quality standards are distinguished in first-tier, when considered essential for robustness unless there is a strong justification for their omission, and second-tier standards, when desirable, but not necessary. First-tier standards ensure credible, self-sustaining research, while second-tier ones enhance quality of investigations and accelerate understanding of CTR-CVT. Adherence to the proposed quality standards is expected to benefit researchers embarking on new investigations, facilitate funding allocation, and inform the development of novel oncological therapies, eventually moving cardio-oncology science forward.
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Authors: Pietro Ameri, Rosalinda Madonna, Ambra Costa, Uri Amit, Ioanna Andreadou, Aarti Asnani, Paul W. Burridge, Carolina Balbi, Gilles W. De Keulenaer, Paul C. Evans, Alessandra Ghigo, Borja Ibáñez, Lorenz H Lehmann, Pilar Martı́n, Giorgio Minotti, Wouter C. Meijers, Éric Morel, Doan Ngo, June‐Wha Rhee, Carol Ann Remme, Carlo G. Tocchetti, Peter van Der Meer, Zoltán V. Varga, Ioannis I. Verginadis, Gerard Walls, Johann Wojta, Teresa López Fernández
Institutions: University of Pennsylvania, Northwestern University, University Medical Center Groningen, University of Groningen, University of Antwerp, Semmelweis University, Heidelberg University, University Hospital Heidelberg, Instituto de Salud Carlos III, Queen's University Belfast, University of Amsterdam, German Cancer Research Center, Erasmus MC, University of Zurich, Federico II University Hospital, Hunter Medical Research Institute, German Centre for Cardiovascular Research, Beth Israel Deaconess Medical Center, University of Turin, University of Newcastle Australia, Newcastle University, Queen Mary University of London, William Harvey Research Institute, Université Paris-Saclay, University of Pisa, Medical University of Vienna, City of Hope, University of Genoa, Tel Aviv Sourasky Medical Center, Campus Bio Medico University Hospital, Hospital La Paz Institute for Health Research, Amsterdam Neuroscience, Amsterdam UMC Location University of Amsterdam, Momentum Research, Ludwig Boltzmann Institute for Age Research, Ludwig Boltzmann Institute Applied Diagnostics, Belfast Health and Social Care Trust, Fondation pour l’innovation en Cadiométabolisme et Nutrition, Kantonsspital Baden, Spanish National Centre for Cardiovascular Research, Azienda Mobilità e Trasporti