Semmelweis University

Association between estradiol and endothelium-dependent vasodilation in the gingiva of young premenopausal women

Abstract Background This study aimed to investigate the associations of age and estradiol levels with gingival blood flow (GBF), with a specific focus on endothelium-dependent vasodilation in premenopausal women during the menstrual (MEN) and periovulatory (OVU) phases of the men...

Outcomes of therapeutic penetrating keratoplasty and deep anterior lamellar keratoplasty in acanthamoeba keratitis: A systematic review and meta‐analysis

While acanthamoeba keratitis (AK) is a sight-threatening corneal infection, a thorough comparison of the outcomes of therapeutic penetrating keratoplasty (PK) and therapeutic deep anterior lamellar keratoplasty (DALK) is lacking. We aimed to compare clinical outcomes of PK and DA...

Diagnostic Accuracy of PID‐5‐BF for Screening Personality Disorders: A Cross‐Sectional Study in Clinical and Nonclinical Samples

ABSTRACT The DSM‐5 Alternative Model for Personality Disorders introduced a dimensional approach to personality pathology, with maladaptive traits assessed by the Personality Inventory for DSM‐5 Brief Form (PID‐5‐BF). Despite extensive validation, evidence on its diagnostic accur...

Efficacy of Sensory Electrical Stimulation Versus Alternating Electromyography-Guided Electrical Stimulation on Functional Recovery of the Hand in Chronic Stroke: A Randomized Controlled Trial

Background Impaired hand function can limit independence. Sensory electrical stimulation (SES) and alternating electromyography-guided electrical stimulation (Alt-EMG) differ in stimulation characteristics and voluntary effort requirements, but comparative evidence is limited. Ob...

Outcomes of Catheter-Free TVT-O Surgery: A Single-Center Case Series

Objectives: Stress urinary incontinence (SUI) significantly affects quality of life. Routine catheterization during and after mid-urethral sling surgery may increase morbidity, and its necessity remains uncertain. This study aimed to evaluate the safety and outcomes of transobtur...

Unveiling Cerebrospinal Fluid Protein Biomarkers in Pediatric Acute Lymphoblastic Leukemia Using a Proximity Extension Assay

Abstract Acute lymphoblastic leukemia (ALL) is a heterogeneous pediatric malignancy where relapse and central nervous system (CNS) involvement remain critical challenges. We combined high-throughput proteomics and machine learning (ML) to identify cerebrospinal fluid (CSF) biomar...

Management Strategies for Cutaneous Adverse Events Caused by Kinase Inhibitors in Oncology: A Systematic Review and Meta-Analysis

Background: The use of targeted therapies in oncology has increased significantly, but associated cutaneous adverse events often impair quality of life and adherence. Despite numerous available interventions, there is no unified protocol, and many patients discontinue therapy due...

Low‐Dose Tumescent Triamcinolone‐Clindamycin Mixture for Hidradenitis Suppurativa: A Case Series

The authors declare no conflicts of interest. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

The EnPlace® Device for Advanced Apical Prolapse: Anatomical Outcomes and Long-Term Satisfaction

Background: Apical pelvic organ prolapse remains a considerable surgical challenge given its comparatively high recurrence rates. The EnPlace® device provides a mesh-free, minimally invasive option for sacrospinous ligament fixation (SSLF). This study evaluates the long-term safe...

Effect of Cyclodextrin Complexation on the Separation of Insulin Analogues in Capillary Electrophoresis Using Dynamically Coated Capillaries

The simultaneous separation of therapeutic insulin analogues by capillary electrophoresis (CE) remains challenging because of their high structural similarity and their tendency to adsorb onto the capillary surface. This study investigated the applicability of cyclodextrin (CD) d...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Biventricular vs conduction system pacing after atrioventricular node ablation for heart failure with atrial fibrillation: the CONDUCT-AF trial.

BACKGROUND AND AIMS: Randomized evidence comparing conduction system pacing (CSP) and biventricular pacing (BVP) following atrioventricular node ablation in patients with refractory atrial fibrillation (AF) and heart failure (HF) remains limited. This study evaluated whether CSP...

Cell type-specific rearrangement of perisomatic inhibition in the valproate mouse model of autism

Autism spectrum disorder (ASD) involves disrupted excitatory/inhibitory balance in brain circuits, with interneuron dysfunction implicated across cortical networks. Perisomatic inhibition by parvalbumin-containing (PV) and cholecystokinin-expressing (CCK) basket cells critically...

Early-onset neonatal sepsis and neonatal antibiotic exposure in Hungary a nationwide population-based study

Abstract Neonatal sepsis remains a challenge in perinatal medicine. We aimed to estimate incidence of culture positive early-onset sepsis (CP-EOS), causative pathogens and overall antibiotic exposure in newborn infants in Hungary. Retrospective national registry analysis (2020–20...

Cardio-Oncological Sequelae of Autologous Stem Cell Transplantation

Autologous hematopoietic stem cell transplantation is a major milestone in modern oncohematological therapies; however, both in the peritransplant and post-transplant phase, the incidence of cardiovascular (CV) events is markedly higher than in the general population. The pathome...

Association of Eplet Mismatch Load and Allograft Injury in Kidney Transplant Recipients

Abstract Introduction Eplet mismatch load is a molecular measure of donor–recipient histocompatibility that has been associated with alloimmune outcomes after kidney transplantation. However, its relationship with comprehensive markers of early allograft injury remains incomplete...

Antibody-drug conjugate engineering: from design to efficacy and safety

Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimizatio...

Novel mTORC1 Booster LAPTM4A Potentiates Pathological Cardiac Hypertrophy

BACKGROUND: Excessive unnecessary protein accumulation in cardiomyocyte is a leading contributor for pathological cardiac hypertrophy and has been found closely regulated by the mTORC1 (mechanistic target of rapamycin complex 1) signaling and lysosome transmembrane proteins. Howe...

Systemic immune-inflammation and inflammation response indices as biomarkers of lymph node metastasis and lymphovascular space invasion in vulvar squamous cell carcinoma

The objective of this study is to evaluate the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) in relation to lymph node metastasis, lymphovascular space invasion (LVSI), tumor size, stromal invasion depth, and p16/p53 status in vulvar squ...

Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice

Microglia closely associate with the vasculature, but their roles in leukocyte trafficking and cerebral blood flow (CBF) during systemic inflammation are unclear. We show that sustained systemic inflammation leads to altered microglia-vascular interactions, leukocyte recruitment...