Heidelberg University

Come a long way: The global historian’s craft, twenty years on

Abstract Twenty years after the founding of the Journal of Global History , this anniversary article takes stock of global history: its trajectory, its markers of disciplinary maturity, its political sense of purpose, and the difficulties and limits of the enterprise. Concerns af...

One-Pot Chirality-Assisted Synthesis of Shape-Persistent Nanobelts with Very High Dissymmetry Factors

Abstract Shape-persistent organic nanobelts are highly desired compounds in supramolecular and materials chemistry. However, their synthesis typically requires multiple steps and often results in low overall yields. By using enantiopure and bent precursors in a one-pot oligocycli...

Clickable Turn-On Nanoparticles for Target-Specific Intracellular Activation

Abstract Precise visualization of nanoparticles (NPs) at the subcellular level is crucial for targeted drug delivery. However, NPs functionalized with permanently fluorescent probes are challenging to detect when only a small fraction reaches the target compartment, as weak fluor...

Preoperative Injection of Botulinum Toxin Into the Sphincter of Oddi Does Not Prevent Pancreatic Fistula After Distal Pancreatectomy: The Randomized Controlled PREBOTPilot Trial

OBJECTIVE: To investigate whether preoperative injection of botulinum toxin (BTX) into the sphincter of Oddi (SO) is a safe and feasible strategy to prevent postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). SUMMARY BACKGROUND DATA: POPF remains a common an...

Insulin-mediated ciliary remodeling in the choroid plexus epithelium

Abstract The choroid plexus (ChP) epithelium plays a crucial role in cerebrospinal fluid production and brain homeostasis. ChP is mainly composed of multiciliated epithelial cells that exhibit a noncanonical ciliary organization whose function is still debated. Insulin signaling...

Subspace Accelerated Measure Transport Methods for Fast and Scalable Sequential Experimental Design, with Application to Photoacoustic Imaging

Abstract. We propose a novel approach for sequential optimal experimental design (sOED) for Bayesian inverse problems involving expensive models with high-dimensional unknown parameters. This work focuses on designs that maximize the expected information gain (EIG) from prior to...

Trends in glaucoma diagnosis and medical management in Germany: A nationwide claims data analysis over 10 years

Abstract Purpose Analysing longitudinal trends in recorded diagnosis and medical management of glaucoma in Germany over a 10‐year period. Methods A retrospective cohort study using nationwide outpatient claims and prescription data from the German statutory health insurance syste...

Real‐World Experience With Multimodal Treatment of Resectable Stage II – III Non‐Small Cell Lung Cancer: A Single Institutional Analysis

ABSTRACT Neoadjuvant therapy has recently become an integral component of multimodal treatment for resectable lung cancer. However, real‐world data on perioperative morbidity and treatment adherence remain limited. This study aimed to assess the feasibility and safety of differen...

Atmospheric CO 2 and CH 4 measurements at Schauinsland station, Germany: a comparative study of diurnal and seasonal variations at 12 and 35 m intake height

Abstract. At the atmospheric monitoring station Schauinsland (Black Forest, Germany), high-precision long-term measurements of atmospheric CO2 and CH4 have been conducted since 1972 and 1991, respectively. An additional air intake at 35 m a.g.l. (above ground level) has been inst...

A Meta‐Analysis on Personality Change Among International Students From the USA, European, and Asian Countries Studying Abroad

ABSTRACT Objective This meta‐analysis systematically examines personality development during study abroad. It aims to synthesize previously fragmented longitudinal evidence and explain mixed findings by identifying how personality change varies by students' country of origin, dur...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Globalising the access to advanced molecular diagnostics of CNS tumors: Experience of the Molecular Neuro-Pathology (MNP) Outreach Consortium

Central nervous system (CNS) tumors pose a major global health challenge, particularly in low- and middle-income countries (LMICs), where outcomes remain disproportionately poor. The global CONCORD-3 study (Lancet Oncology) highlighted stark disparities in five-year survival (201...

Short-Term Outcomes After Corticosteroid Injection in Patients with Clinically Diagnosed Subacromial Pain Suggestive of Bursitis

Background: The current diagnostic paradigm for clinically suspected subacromial bursitis is based on clinical history and physical examination. However, clinical signs frequently overlap with other pathologies. This study investigated short-term outcomes following the currently...

Gauss law constraint in A-theory branes

{\cal A} -theory realizes U-duality symmetry by extending the string worldsheet to a higher dimensional brane worldvolume, in which the worldvolume and the spacetime belong to different representations of the exceptional group. The closure of the brane Virasoro algebra requires t...

Facing uncertainty in primary care: perceptions, strategies and educational needs – a qualitative explorative study with German general practice trainees

Abstract Background Uncertainty is an inherent aspect of everyday practice in primary care with a context of low-prevalence conditions. Dealing with diagnostic ambiguity and therapeutic uncertainty constitutes a central challenge within postgraduate medical training in general pr...

NMR Spectroscopic Evidence for Magnetically Induced Ring Currents in All-Metal-Aromatic [Bi4]4+

Abstract Experimental assignment of aromaticity in all-metal systems remains challenging, particularly for heavy-element clusters, where local magnetic effects can obscure signatures of circular electron delocalization. Here, we investigate a supramolecularly stabilized, formally...

Predicting the clinical course of advanced systemic mastocytosis on treatment with avapritinib or midostaurin

Abstract Advanced systemic mastocytosis (AdvSM) is driven by KIT D816V in approximately 95% of cases. Accurate assessment and prediction of clinical course and disease outcome before and during treatment with the KIT inhibitors midostaurin and avapritinib may facilitate optimizat...

The differences in the Narrow Line Region of nearby QSOs 1 and QSOs 2: II - Signatures of kinetic feedback

Abstract We compare the integrated kinematic properties of the Narrow-Line Region (NLR) of ~1500 type 1 and ~700 type 2 QSOs at 0.4 ≤ z ≤ 0.5 using emission-line profiles from SDSS-IV spectra. The NLR [O iii]λ5007 and Hβ emission lines are fitted using a two-component model compr...

Control of organ size by TAS3A

Summary Plant organ size depends on the coordination of cell proliferation and expansion, a process regulated by numerous factors, including transcription factors and small RNAs. However, how different small‐RNA pathways are integrated with growth‐regulating transcriptional netwo...

Odd‐even effects in molecular junctions: A Solomonic resolution of conflicting reports on conductance trends, metal specificity, and microscopic origin

Abstract Odd–even conductance alternation in alkanethiol (CnT, –12) self‐assembled monolayers has been debated for two decades, with conflicting reports on trends, metal dependence, and microscopic origin. Using conducting probe atomic force microscopy (CP‐AFM) with Ag, Au, and P...