Tel Aviv Sourasky Medical Center

Intraoperative Management Strategies for Unresectable Pancreatic Adenocarcinoma: A Propensity-Weighted Cohort Study

BackgroundWhen pancreatic adenocarcinoma is found unresectable during surgery, the decision to perform palliation must balance symptom relief against recovery and subsequent cancer treatment. We compared clinical outcomes after palliative procedures and nontherapeutic exploration...

Growth and Clinical Outcomes Before and After Implementation of a Donor Human Milk Program in Very Preterm and/or Very-Low-Birth-Weight Infants

Background/Objectives: Mother’s own milk (MOM) is widely recognized as the best source of nutrition for premature infants, with donor human milk (DHM) as the next recommended option. However, it remains controversial whether DHM confers the same benefits as MOM. We aimed to compa...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

HoLEP Versus Mini-HoLEP: A Long-term Follow-up Prospective Randomized Controlled Trial

Background and objective Holmium laser enucleation of the prostate (HoLEP) is increasingly performed with miniaturized instruments, aiming to reduce postoperative urinary incontinence (UI). Evidence for mini-HoLEP (MiLEP) using a 22-Fr resectoscope remains largely retrospective o...

Treatment Persistence and Factors Associated With Discontinuation in Real‐World Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps

ABSTRACT Background Biologic therapies are effective for severe, uncontrolled CRSwNP, yet real‐world data on treatment persistence remain limited. Methods This retrospective single‐center study included 95 adults with CRSwNP who initiated dupilumab (88.4%), mepolizumab, or omaliz...

From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction

ABSTRACT Objective To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR). Methods A retrospective cohort of 320 consecutive FGR pregnancies presenting at ≥...

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric intramedullary low-grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross-total resection is frequently unfeasible due to the inf...

Preoperative glycemic control and outcomes following metabolic and bariatric surgery in patients with type 2 diabetes

Abstract Background Metabolic and bariatric surgery (MBS) is an effective treatment for patients with obesity and type 2 diabetes (T2D). Preoperative T2D severity may influence perioperative safety and T2D outcomes after MBS. Methods A retrospective analysis of a single-center da...

PD GENEration: an international Parkinson’s disease genetic research study

Abstract Background PD GENEration (NCT04057794, NCT04994015), sponsored by the Parkinson's Foundation in partnership with Aligning Science Across Parkinson’s (ASAP) through the Global Parkinson’s Genetics Program (GP2), is an international, observational, clinical research study...

Deep learning-based body weight estimation from lower abdominal CT scans

Abstract Body weight is a key parameter for assessing the risk of an osteoporotic hip fracture by autonomous finite element analysis based on lower abdominal computed tomography (CT) scans. To allow opportunistic diagnosis of this fracture risk by any lower abdominal ? CT scan, w...

Cerebrovascular Manifestations in a Family with a Pathogenic COL4A5 Variant

Background/Objectives: Pathogenic variants in collagen type 4 α5 chain (COL4A5), responsible for X-linked Alport syndrome, are classically associated with progressive kidney disease, sensorineural hearing impairment, and ocular abnormalities. Cerebrovascular involvement is not co...

Heart rate variability and physician performance during airway management simulations: an exploratory pilot study

OBJECTIVE: To examine the association between heart-rate variability (HRV) and physician performance during airway management simulations in two physician cohorts studied under different HRV measurement conditions. METHODS: This exploratory pilot study included otolaryngologists...

The clinical and phenotypic spectrum of PTEN hamartoma tumor syndrome: a retrospective cohort study

Abstract PTEN Hamartoma Tumor Syndrome (PHTS) is a rare condition characterized by a complex phenotype including gastrointestinal hamartomas and increased lifetime malignancy risk. To characterize the clinical phenotype, genetic landscape, and spectrum of malignancies within a la...

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

Two-Year Clinical Outcomes of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression

OBJECTIVES: To assess 24-month clinical outcomes of vagus nerve stimulation (VNS) in individuals with higher-grade treatment-resistant depression (HG-TRD) treated within a national open-label program, focusing on depressive severity, suicidality, safety, tolerability, and rates o...

Decisional regret following avoidance of epidural analgesia in labor

Epidural analgesia (EPA) is a commonly employed technique of providing pain relief during labor. However, a subset of women elects to avoid this option, motivated by personal, cultural, or medical reasons. While the clinical outcomes of EPA have been widely studied, the emotional...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

From Rapid Progression to Long-Lasting Complete Response: A Wide Range of Ripretinib Activity for Metastatic GIST—A Real-World Cohort

Background: Ripretinib, a switch-control kinase inhibitor approved for advanced gastrointestinal stromal tumor (GIST), inhibits primary and secondary KIT and PDGFRA mutations. Real-world data from Western and Middle Eastern populations remain limited. We report outcomes from a mo...

Global variability in cardiovascular care of pediatric cancer patients and survivors: survey results from the International Cardio Oncology Society (ICOS)

Childhood cancer survivors (CCS) are at elevated risk for cardiovascular disease due to cardiotoxic cancer therapies. Different international guidelines and recommendations for follow-up were published. However, global practices surrounding cardiovascular risk assessment, screeni...

The impact of chronic loop diuretic therapy on urinary microbiology and clinical outcomes in hospitalized older adults

Urinary tract infections (UTIs) are common among hospitalized older adults and are closely linked to antibiotic exposure and antimicrobial resistance. Loop diuretics are widely prescribed in this population and substantially alter urine volume and composition. However, their pote...