Ludwig Boltzmann Institute Applied Diagnostics

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

CpG 1018 and alum synergistically enhance systemic and mucosal immunity to an N2 neuraminidase vaccine

Recombinant neuraminidase (rNA) is a promising target for broadly protective influenza vaccine development but typically requires adjuvants, especially for intranasal (IN) delivery. We evaluated an N2 rNA vaccine construct (globular head domain of NA, stabilized with a measles vi...

Histological aging signatures for monitoring tissue-specific aging and disease

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types acro...