University of Genoa

A community-validated tool for clinical outcome calculation in multiple sclerosis: Consensus development and scenario-specific recommendations

Background: Reproducibility and comparability of disability outcomes remain major challenges in multiple sclerosis (MS) research. Definitions of disability progression vary widely across studies, and calculation criteria are often insufficiently documented to enable replication....

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

On the Axiom of the Second Law of Thermodynamics and the Modelling of Flexoelectricity

The present paper addresses models of non-local materials and, in particular, flexoelectric materials as dielectrics with higher-order gradients. While the literature develops the subject through variational formulations, here the modelling is developed within a thermodynamic fra...

Effectiveness of Therapeutic Sport Footwear in Prevention of Ulcer Recurrence in Persons with Diabetic Foot Disease

Recurrence of diabetic foot ulcer (DFU) remains a major clinical challenge in patients with diabetes. Therapeutic footwear is a cornerstone of secondary prevention as it reduces plantar pressure and mechanical stress. However, most available evidence focuses on traditional orthop...

Rim-driven pumpjet design by optimization

Abstract This paper presents a numerical study based on a Simulation-Based Design Optimization (SBDO) framework for the design of a marine rim-driven pumpjet propulsion system at a prescribed operating condition. The main objective is to compare the hydrodynamic performance of ri...

Continuous Glucose Monitoring and Automated Insulin Delivery in Infants with Type 1 Diabetes: Real-World Evidence to Support Future International Guidelines

To evaluate efficacy and safety of continuous glucose monitoring (CGM) and automated insulin delivery (AID) in infants. A retrospective multicenter study (13 centers) of 76 children diagnosed with antibody-positive type 1 diabetes before age 2. Outcomes at 12 months were compared...

How Polymer ChainsRemember Their Crystalline Past:Simulations Uncover the Molecular Origin of Melt Memory

Abstract Melt memory in semicrystalline polymers is the remarkable ability of polymer chains to retain structural information from a prior crystalline state after being heated above the melting temperature. This phenomenon can induce extraordinary self-nucleation and strongly inf...

Storm surge dynamics in the northern Adriatic Sea: comparing AI emulators with high-resolution numerical simulations

Abstract. Accurate storm surge forecasting is vital for protecting coastal regions, particularly in the northern Adriatic Sea where sea-level rise and increasingly severe storm events pose growing risks. Machine Learning (ML) approaches offer compelling speed and flexibility, yet...

Susceptibility haplotypes in non-cystic fibrosis newborns with elevated immunoreactive trypsinogen

Cystic fibrosis (CF) represents the most prevalent life-threatening autosomal recessive disorder in Europe, primarily affecting the respiratory tract, exocrine pancreatic function, and lipid metabolism. Immunoreactive trypsinogen (IRT) quantification constitutes the first-tier te...

Does an Unconventional Source with a High Silica Content (Obsidian) or a High Alumina Content (Bauxite) Affect the Type of Potassium Zeolite Formation? Preliminary Data on Synthetic Products’ Efficiency in Ammonium Removal

In this paper, obsidian (OS) and bauxite (BX) are used to synthesize zeolites via KOH prefusion, followed by a conventional hydrothermal process (HY) or an unconventional vapor-phase crystallization method (VPC) at 90 °C. The results indicate that, due to their chemical and miner...

Visceral-to-subcutaneous fat ratio is a time-stable predictor of survival and toxicity in advanced hepatocellular carcinoma

Abstract Purpose Nutritional status significantly impacts the prognosis of patients with hepatocellular carcinoma (HCC). Computed tomography (CT) has become a key tool for assessing body composition (BC), with abnormal patterns increasingly linked to reduced survival. However, BC...

Spinors Beyond Dirac, Weyl and Majorana: The Flag-Dipoles

Abstract We recall the Lounesto classification of 1/2-spin spinor fields, based on the vanishing of spinorial bilinear quantities: the classes are the regular spinor fields (i.e. the Dirac field), as well as singular spinor fields, also known as flag-dipole spinor fields, admitti...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Influence of Relative Permeability Formulations on Hysteretic Seepage in Infinite Slopes

ABSTRACT The paper investigates the impact of two classical relative permeability formulations, one expressed in terms of pore water pressure and the other in terms of degree of saturation, on the predicted seepage in an infinite slope subjected to surface pore pressure variation...

Development of a comprehensive multidisciplinary approach for monitoring marine port environments

Monitoring is an essential tool to understand the environment, periodically check processes in place, and highlight the occurrence of natural or human-induced changes, especially in case of anthropic environments, such as ports and their water bodies. To ensure that as much infor...