Newcastle University

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

Knowledge, attitudes and perceptions about influenza vaccination among pregnant women in Kuwait: a descriptive cross-sectional study

Abstract Maternal influenza vaccination (MIV) is the most effective measure of preventing severe influenza-related complications in pregnant women. However, there is limited knowledge about MIV uptake in Kuwait. This study aimed to assess pregnant women’s knowledge, attitudes, an...

P1.162. Does Deprivation Drive Outcomes? Socioeconomic Factors in Esophageal Cancer Resections

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophageal cancer incidence is higher in socioeconomically deprived populations. While deprivation is linked to established risk factors, its impact on tumour stage, comorbidity burden, and posto...

P1.204. Comparison of Freka and MIC Feeding Jejunostomy Complications After Ivor Lewis Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Feeding jejunostomy is frequently used as a nutritional adjunct following esophagectomy. Its routine placement remains debated, partially due to concerns regard...

The ‘legging up’ burden: Hidden struggles of model minorities in racialized mentoring at work

Drawing on contemporaneous microstoria narrated by Black model minorities (BMMs), this paper theorizes the legging up burden: the implicit expectation that BMMs, positioned as token representatives of their race, will provide mentoring and support to organizational members with w...

Affected others’ perspectives on the burden, drivers, and prevention of gambling-related harms: a qualitative study

Abstract Background Gambling is increasingly recognised as a public health concern, with harms extending beyond individuals who gamble to families and communities. However, young people and adults affected by others’ gambling remain under-represented in research on harm preventio...

P1.125. Challenging a Histology-Led Paradigm: Comparable Real-World Survival After Definitive Non-Surgical Treatment in Oesophageal Adenocarcinoma and Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Histology is often treated as a surrogate for radiosensitivity in oesophageal cancer, sustaining the prevailing assumption that squamous cell carcinoma (SCC) benefits more from definitive chemoradiotherapy th...

Aesthetic persuasion in theater-based interventions: Exploring persuasive capacities of theater as a mode of management learning and education

The article provides a framework for theorizing aesthetic persuasion in theater-based interventions as a mode of management learning and education. Taking an analytical look at the use of dramatic and postdramatic theater in critical management education, we apply the notion of a...

Pulsations in Binary Star Systems

High-precision and long-duration light curves from space telescopes have revolutionized the fields of asteroseismology and binary star systems. In particular, the number of pulsating systems in eclipsing binaries has drastically increased thanks to space-based observations coveri...

On The Geometry of Time in Rational Agency

Standard economic theory treats time as an exogenous, linear parameter that indexes choice and coordination. This paper argues that such treatment obscures a constitutive feature of rational agency. We develop a coherence-based framework in which the temporal structure relevant t...

Evidence charts the future of freshwater biodiversity conservation

Evidence is essential for promoting freshwater conservation and selecting appropriate conservation actions. This article examines the importance of evidence for freshwater conservation, available sources, how evidence is used, geographical coverage, and the challenges in obtainin...

Beyond the protocol: navigating ethics and governance in the multicentre implementation trials – the QASC Australasia and T3 Trials

OBJECTIVE: To describe and compare ethics and governance approval timelines for the Quality in Acute Stroke Care (QASC) Australasia Trial (2021-present) and Triage, Treatment, and Transfer of Patients with Stroke in Emergency Departments (T3) Trial (2012-2014), benchmarking again...

Ontology-Driven Modeling and Semantic Integration of Attack, Protection, and Risk Domains in Electric Vehicle Charging Systems

Electric Vehicle Charging Systems (EVCSs) have become a critical component of the global transition toward sustainable and intelligent transportation. However, their tight integration with heterogeneous cyber–physical, vehicular, and cloud-based infrastructures exposes them to an...

The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis

Abstract Exercise orchestrates an interorgan communication network, in which skeletal muscle releases signaling molecules known as myokines that contribute to exercise training-induced adaptations. We identified the muscle-derived metabolite beta-aminoisobutyric acid (BAIBA) as a...

The Impact of Conflict on Maternal and Child Health Services: A Scoping Review

Abstract Conflicts are unavoidable aspect of human existence, causing disruptions in livelihoods, infrastructure, socioeconomic systems and healthcare access. Among the most severe effects of conflict are those on maternal and child health (MCH) services, on which there is a nota...

Characterizing the Landscape of Loss: A Spatiotemporal Contextual Approach to Measuring U.S. County-Level Depopulation

In recent decades, the United States has experienced substantial changes in population size, composition, and distribution. As growth has slowed, population loss has taken on increased salience, presenting an emerging social, economic, and political challenge and highlighting a n...

Federated Edge-HPC Architectures for AI Workflows in Privacy-Sensitive and Real-Time Domains – Final Report

This report presents the outcomes, technical evaluations, and roadmap recommendations of the “Federated Edge-HPC Architectures for AI Workflows in Privacy-Sensitive and Real-Time Domains” (FEDGE) project, funded by the UKRI National Federated Compute Services (NFCS) NetworkPlus.

Group sequential designs and a sample size reestimation approach for partially nested trials

Abstract Background Randomized controlled trials are the gold standard for evaluating interventions. For individually randomized trials, clustering can exist in the intervention arm but not the control arm when the intervention is delivered by study personnels and/or in a group s...

Federated Edge-HPC Architectures for AI Workflows in Privacy-Sensitive and Real-Time Domains – Final Report

This report presents the outcomes, technical evaluations, and roadmap recommendations of the “Federated Edge-HPC Architectures for AI Workflows in Privacy-Sensitive and Real-Time Domains” (FEDGE) project, funded by the UKRI National Federated Compute Services (NFCS) NetworkPlus.

ImmTACs overcome cytotoxic T cell suppression

Abstract Immune mobilizing monoclonal TCR against cancer (ImmTAC) are cancer therapeutics that activate T cells through recognition of a tumor-associated antigenic MHC/peptide complex. A first-in-class ImmTAC, Tebentafusp, is approved for the treatment of metastatic uveal melanom...