Newcastle University

Paediatric haematopoietic stem cell transplantation research priorities: Results from an international multi‐stakeholder priority setting partnership

Summary Co‐designed research in paediatric HSCT is limited. We sought to determine research priorities which represent the shared priorities of patients, parents, carers and healthcare professionals (HCP) within Australia, New Zealand, the Netherlands and the United Kingdom. An i...

Cloud‐Native and Distributed Systems for Efficient and Scalable Large Language Models—A Research Agenda

ABSTRACT Objective Large Language Models (LLMs) are rapidly transforming artificial intelligence applications, but their unprecedented computational, memory, communication, and data‐management demands pose significant challenges to existing computing infrastructures. Traditional...

Factors influencing medication management during emergency department-to-home transitions: a qualitative study using the theoretical domains framework

Abstract Introduction The transition from Emergency department (ED) to home represents a high-risk period in the continuum of patient care, increasing the risk of medication errors, adverse drug events, and poor adherence. This study explored the perspectives of key stakeholder g...

Do textual attributes of management commentary matter for analyst coverage and information quality: evidence from the United Kingdom

Purpose This study examines whether the readability of management commentary is associated with analysts' coverage and the precision of analysts' information sets. It further investigates whether analysts' experience, access to resources and forecast boldness moderate these relat...

Front-line decision-making: a thematic analysis of interviews with hospital staff on referrals, admissions, and care for people with multiple long-term conditions

BACKGROUND: Multiple long-term conditions (MLTC) are increasingly common and present challenges for hospital healthcare professionals (HCPs) making decisions about admissions, referrals, and care management in the context of a single-organ oriented health system. This qualitative...

‘People need to be a bit more understanding that my body is wrecked’: A qualitative exploration of inpatient hospital care for people living with multiple long-term conditions

BACKGROUND: Living with multiple long-term conditions (MLTC) is becoming increasingly common with far-reaching consequences for individuals and healthcare systems. People with MLTC often face complex care pathways through health systems - especially hospitals, which are largely c...

Evaluation of Physics-Based Pose Prediction and the Role of Receptor Flexibility in a Community Antiviral Blind Challenge

Abstract Prediction of protein–ligand binding modes is a key step in computer-aided drug design, since incorrect pose prediction inevitably limits the achievable accuracy of downstream physics-based affinity predictions. The ASAP-Polaris-OpenADMET antiviral competition was launch...

Encounters with Photobooks: How Art and Experience Matter

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Shoaling of internal solitary waves over linear slopes with variable topography

This study investigates the influence of variable topography on the kinematics of internal solitary wave shoaling across various breaking regimes under the unifying condition of a slope-intersecting pycnocline. It is demonstrated that bottom corrugations can significantly modify...

Nutrients and Their Role in Autophagy Regulation

Abstract Autophagy is a fundamental catabolic pathway that maintains cellular homeostasis through the degradation and recycling of intracellular components in response to nutrient limitation and metabolic stress. Increasing evidence indicates that autophagy is tightly regulated b...

UK consensus recommendations for onward testing for Lynch syndrome in patients with deficient mismatch repair (dMMR) non-colorectal/non-endometrial cancers

Accepted: 2026) UK consensus recommendations for onward testing for Lynch Syndrome in patients

Experimental manipulation of ecological constraints influences conflict but not cooperation in the humbug damselfish Dascyllus aruanus

Animal societies vary widely in levels of cooperation and conflict, and understanding the causes of this variation is a central goal in evolutionary biology. As with other features of animal societies, relatedness, competitiveness and ecological constraints (e.g. habitat saturati...

Ancient terrestrial forests reborn as modern marine ecosystems under shifting sea levels

Abstract Sea-level rise and coastal erosion can submerge terrestrial carbon-rich landscapes, yet the ecological fate and climate significance of such relict coastal carbon deposits remain largely unknown. We report the discovery of submerged tropical peat reefs in the shallow coa...

Frequency security-aware production scheduling of utility-scale off-grid renewable P2H systems coordinating heterogeneous electrolyzers

Renewable power-to-hydrogen (ReP2H) enables large-scale renewable energy utilization and supports the decarbonization of hard-to-abate sectors, such as chemicals and maritime transport, via hydrogen-based renewable ammonia and methanol fuels. As a result, utility-scale ReP2H proj...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Geography in the World Part 4: Towards Latin American Dialogues

ABSTRACT This fourth instalment of Geography in the World (GitW) aims to deepen engagement with geographical knowledge produced outside the Anglophone core—specifically, in Latin America—while reflecting on the practical challenges involved in doing so. The themed intervention co...

Exploring Understanding and Experience of Responsibilities for Marginalised Fieldworkers’ Safety and Wellbeing with Recommendations for more Inclusive Approaches

Abstract Fieldwork is an important component of research at higher education institutions (HEIs). Fieldworkers often find themselves in challenging physical or social environments, and those with marginalised characteristics or with intersecting marginalised characteristics can f...

Blockchain-enabled construction contract administration for extension of time claims: a practice-aligned framework and system

Purpose Existing digital solutions for construction contract administration (CCA) inadequately reflect the complexity and contractual logic of established contract forms. This study addresses this gap by developing a permissioned blockchain-based system – ChainedEOTClaim – for ma...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Semantic Interference From First- and Second-Language Maskers During Speech-on-Speech Listening

PURPOSE: Broad linguistic properties of masker speech (e.g., phonological and prosodic familiarity) have been shown to affect target speech transcription during speech-on-speech listening. However, it is unclear whether the semantic content of the masker impacts listening accurac...