William Harvey Research Institute

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

Apc-deficient pituitary stem cells drive adamantinomatous craniopharyngioma through senescence-associated inflammation

Abstract Adamantinomatous craniopharyngiomas (aCPs) are complex intracranial neoplasms that arise in the sellar and suprasellar region of the brain, affecting the endocrine and nervous systems, causing severe sequelae. Although most of aCPs are driven by somatic mutations in β-ca...

Acceptability of advanced monitoring for acute respiratory failure requiring non-invasive respiratory support: A qualitative study of perceptions from patients and critical care practitioners

Background Advanced monitoring instruments can provide detailed assessment of work of breathing in patients with acute hypoxaemic respiratory failure (AHRF) managed with non-invasive respiratory support (NRS). Despite increasing availability, uptake in routine clinical practice r...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Effects of Sarpogrelate Hydrochloride in Combination with Aspirin on Blood Viscosity and Hemorheological Parameters in Patients with Peripheral and Coronary Artery Disease: A Randomized Controlled Trial

Background/Objectives: Hemorheological abnormalities, including increased blood viscosity and impaired red blood cell (RBC) deformability, contribute to poor vascular outcomes in patients with atherosclerotic diseases. Although sarpogrelate has shown vascular benefits, its additi...

Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4

Nascent vascular networks adapt to the increasing metabolic demands of growing tissues by expanding via angiogenesis. As vascular networks expand, blood vessels remodel, progressively refining vascular connectivity to generate a more haemodynamically efficient network. This is dr...

Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score

ABSTRACT Background Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and out...

TSPO: a conserved mitochondrial conduit linking cellular homeostasis to disease

Abstract The translocator protein (TSPO) is an evolutionarily conserved 18 kDa protein localised to the outer mitochondrial membrane and increasingly recognised as a multifunctional regulator of cellular homeostasis. Although initially identified as the peripheral benzodiazepine...

Acute kidney injury and renal replacement therapy: a critical synthesis of metabolic derangements and nutritional implications

Acute kidney injury (AKI) affects up to 50% of critically ill patients and is frequently complicated by severe metabolic derangements, requiring the initiation of replacement therapy (RRT) in 10–15% of cases. Despite substantial progress in the diagnosis of AKI and optimisation o...

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa

ABSTRACT: Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate associations of pain with critical...

The central role of fatigue and sleep in health behaviors during the COVID-19 pandemic

To explore the associations between perceived fatigue and various health behaviors in a Brazilian adult sample using network analysis during the COVID-19 pandemic. Data were collected via an online questionnaire between July 2020 and February 2021, including sociodemographic info...