William Harvey Research Institute

TSPO: a conserved mitochondrial conduit linking cellular homeostasis to disease

Abstract The translocator protein (TSPO) is an evolutionarily conserved 18 kDa protein localised to the outer mitochondrial membrane and increasingly recognised as a multifunctional regulator of cellular homeostasis. Although initially identified as the peripheral benzodiazepine...

Acute kidney injury and renal replacement therapy: a critical synthesis of metabolic derangements and nutritional implications

Acute kidney injury (AKI) affects up to 50% of critically ill patients and is frequently complicated by severe metabolic derangements, requiring the initiation of replacement therapy (RRT) in 10–15% of cases. Despite substantial progress in the diagnosis of AKI and optimisation o...

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa

ABSTRACT: Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate associations of pain with critical...

The central role of fatigue and sleep in health behaviors during the COVID-19 pandemic

To explore the associations between perceived fatigue and various health behaviors in a Brazilian adult sample using network analysis during the COVID-19 pandemic. Data were collected via an online questionnaire between July 2020 and February 2021, including sociodemographic info...