Queen's University Belfast

Dose-dependent microbiome, metabolome and lipidome shifts in a mouse model of colitis-associated colorectal cancer using azoxymethane and dextran sodium sulphate

Colorectal cancer (CRC) remains a major health burden, underscoring the need for continued research to improve screening methods and treatment outcomes. The colitis-associated azoxymethane (AOM) and dextran sodium sulphate (DSS) mouse model has proven valuable for CRC research, a...

Impact of diabetes mellitus on the menopausal experience: A scoping review

Abstract Aims To identify, appraise and synthesise the current evidence relating to symptoms, experiences, management and impact of menopause on QoL among women with type 1 diabetes (T1DM) or type 2 diabetes (T2DM) and to identify evidence gaps. Methods We conducted a scoping rev...

Citizen finance for a just energy transition? Analysing UK experience, and exploring potential for smart local energy systems

The UK energy transition is projected to require billions of pounds of investment, not only in renewable supply, but also in demand-side technologies and system management. While this investment is expected to come from large scale commercial finance, both citizen finance and sma...

Synergistic effects of acetic acid and sulfate on the degradation of ternary and alkali-activated concretes

Degradation of concrete structures exposed to silage effluent is primarily caused by the organic acids destabilising calcium-bearing phases in the cementitious materials. The performance of a ternary cement (Portland cement, ground granulated blast-furnace slag (GGBS) and silica...

Antimicrobial peptides for tuberculosis in a post-antibiotic era: from in vitro promise to therapeutic potential

Abstract Tuberculosis remains the leading cause of death from a single infectious pathogen, driven by prolonged treatment regimens and escalating drug resistance. Antimicrobial peptides represent a promising alternative therapeutic class with diverse mechanisms and limited resist...

Preserving Marginalised Identity through the Long Kesh Style Collection

Long Kesh/The Maze Prison (LK/M) is considered one of the most dominant symbols of the conflict between prisoners and government authorities during “The Troubles.” Holly Lennon has assembled hundreds of items, belonging to republican prisoners during the 1976-1981 prison protests...

Mapping with Uncertainty: Digitising and Preserving the 1826 Education Inquiry

The 1826 Second Report of the Commissioners of Irish Education Inquiry is the most extensive surviving survey of schooling in pre-Famine Ireland, recording teachers, pupil counts, and denomination-specific enrolment as reported by Protestant and Roman Catholic clergy. While found...

Rhomboid protease RHBDL2 is a calcium-activated suppressor of EGFR signalling in keratinocytes

Abstract Signalling via the epidermal growth factor receptor (EGFR) is indispensable for morphogenesis and tissue homeostasis. It is activated by extracellular ligands, typically released from transmembrane precursors by proteolysis. Ligand shedding activity is provided by the co...

Terrain‐Adaptive Quadrupedal Locomotion Using Model Predictive Control With Impedance Control and SINDy Model Enhancement

ABSTRACT Quadrupedal robots operating in unstructured environments require adaptive control systems that can handle diverse terrain conditions without prior surface characterization. This paper presents an integrated control architecture that combines Model Predictive Control (MP...

Obtaining a Diagnostic Yield via Scan findings prior to the introduction of SEquencing retrospectivelY ( ODYSSEY ): a cohort study

ABSTRACT Objective To determine the retrospective yield of prenatal exome sequencing (PES) by establishing the proportion of children with a postnatal monogenic diagnosis that could have been diagnosed prenatally if PES had been available. Methods The study cohort comprised a sam...

Young people’s resistance within and against unjust systems: The possibilities and challenges of participatory action research-enabled social innovation and social entrepreneurship

This article establishes a dialogue between the fields of participatory action research, social innovation and social entrepreneurship, by presenting learning from two projects with young people in Colombia and critically situating it within intersectional, intergenerational and...

Incidence, Patterns and Predictors of Alemtuzumab‐Induced Thyroid Dysfunction in Patients With Multiple Sclerosis: A Northern Ireland Cohort Study

ABSTRACT Background Alemtuzumab (Lemtrada) is highly effective for selected relapsing multiple sclerosis (MS) but can cause autoimmune thyroid dysfunction (AITD). Our aim was to retrospectively review patients and the monitoring of their thyroid function tests (TFTs) during and a...

Measuring masses of transiting Earth-like planets: first insights from the PLATO RV Data Challenge

Abstract The PLATO Stellar Variability Mitigation Working Group designed a radial-velocity (RV) data challenge to assess the precision and accuracy achievable on RV semi-amplitudes in the context of the future PLATO follow-up. Using Sun-as-a-star observations obtained with HARPS-...

Mechanochemically Prepared Supported Ionic Liquids for Efficient Glycerol Valorization to Glycerol Carbonate

Abstract The valorization of glycerol, a major byproduct of the biodiesel industry, into high value chemicals offers a sustainable pathway to support circular economy objectives within biorefineries. Among various transformation routes, the transesterification of glycerol with di...

Microbial interactions as key players shaping the emergence and spread of de novo resistance mutations

Antibiotic resistance and the microbiome are two of the most prominent and highly active research areas currently in microbiology. However, these studies are commonly siloed. Research into antibiotic resistance often takes a highly pathogenic-centric view, and microbiome studies...

From Comprehensive Distrust to Unquestioned Trust in Street-based Outreach Work With People Who Use Drugs in Finland

People who use drugs may experience comprehensive distrust in other people due to drug-related stigma and other violating experiences in services and in their life course. This may prevent them from seeking help. The goal of strengthening trust in services has been supported in s...

The Idea of the Female Club: The Case of An Account of the Fair Intellectual-Club (Edinburgh, 1719)

Associational culture in the eighteenth century has been the subject of sustained attention in modern scholarship of the period, but relatively little attention has been paid to female clubs and associations. Usually this is because of the lack of evidence that female-only societ...

Awake craniotomy for drug-resistant non-oncological epilepsy: a systematic review of feasibility, reported safety, and seizure outcomes

Abstract Introduction Complete resection of the epileptogenic zone offers the best chance of seizure control in patients with drug-resistant epilepsy. However, surgical management remains challenging when the epileptogenic zone is located within or adjacent to eloquent brain regi...

Coppiced sweet chestnut in the construction of imperfect gridshells from asymptotic curves

In recent years, bending-active gridshells with asymptotic geometry have been successfully constructed at the architectural scale. These have typically used materials such as steel and machined timber, with thin rectangular profiles and predictable characteristics. This paper inv...

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Breast cancer stemness drives tumor progression and therapy resistance, yet the underlying mechanisms remain poorly understood. In this study, we observed that RBM38 expression gradually decreases during breast cancer progression in MMTV - PyMT transgenic mice. Using a model with...