Federico II University Hospital

A Kaizen perspective for managing human-technology continuous improvement in the digital age

Purpose The paper examines how digital technologies are transforming continuous improvement (CI) by altering the cognitive and relational dynamics that have long underpinned Kaizen-oriented learning. Design/methodology/approach This paper adopts a conceptual approach, drawing on...

The Broad Clinical Heterogeneity of TRNT1-Related Autoinflammatory Syndrome: A Comprehensive Review

Mutations in the tRNA Nucleotidyl Transferase 1 (TRNT1) gene have been associated with a systemic autoinflammatory disease (SAID) that presents with a wide clinical spectrum, ranging from severe and fatal forms to milder disorders. We conducted a literature review to provide a co...

Training the Next Generation of Future Surgical Residents: A Scoping Review and Proposal for an Undergraduate Curriculum From the Italian Polispecialistic Society of Young Surgeons

AIM: The transition from medical school to surgical residency is marked by a persistent gap between theoretical instruction and clinical readiness. In Italy, variability in training programs across centers creates persistent gaps in residents’ medical education. Scientific societ...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Revisiting Inherited Metabolic Diseases ( IMDs ) Through the Lens of Selective Autophagy

ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen,...

Challenges and strategies for dredged sediment decision management in Venice lagoon (Italy)

This study presents the results of extensive sediment characterization campaigns conducted in 2024-2025 on more than 400 sediment cores collected across the Venice Lagoon, yielding approximately 1400 samples analyzed for chemical contamination and ecotoxicity. Investigated sedime...

Impact of GLP-1 Receptor Agonists on Cognitive Performance in Adults at Risk of Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background/Objectives: Type 2 diabetes, a widely recognized risk factor of Alzheimer’s disease (AD), is mainly due to the role played by insulin resistance on neuronal degeneration. Mild Cognitive Impairment (MCI) also significantly increases the risk of developing AD by approxim...

Preserving anthracycline-containing treatment in older patients with classical Hodgkin lymphoma: a role for liposomal doxorubicin. Comment on: "Age, anthracycline and mortality in 28,000 classic Hodgkin lymphoma patients: cohort study of a complete population"

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The reactivation of the Niscemi landslide (southern Italy) after the Cyclone Harry

Abstract On January 25, 2026, a large compound slide affected the southern and western slopes of the Niscemi mesa (SE Sicily), causing severe damage to settlements and the evacuation of approximately 1500 people. The event occurred approximately one week after Cyclone Harry, whic...

Single-dose versus short-course antibiotic prophylaxis in laparoscopic right hemicolectomy with intracorporeal anastomosis: a retrospective cohort study

To date, data on effectiveness of different antibiotic prophylaxis protocols on surgical site infections (SSI) after laparoscopic right colectomy with intracorporeal anastomosis (LRC-IA) are scarce. The aim of this double-centers retrospective study was to compare 30-day Organ/Sp...

Real‐World Effectiveness and Safety of Topical Ruxolitinib in Adolescents With Vitiligo: A 52‐Week Retrospective Study

ABSTRACT Background Topical ruxolitinib, a selective JAK1/2 inhibitor, is the first approved topical therapy for repigmentation in non‐segmental vitiligo in patients aged 12 years and older. Real‐world data in adolescents remains limited. Objectives To evaluate the real‐world eff...

Medical liability in paediatric robotic surgery – a current concept and a literature review

Abstract Robotic-assisted surgery offers significant technical advantages in pediatric procedures but presents complex, unresolved medico-legal challenges regarding liability. We retrospectively reviewed our ten-year experience comprising 205 pediatric robotic procedures. Technic...

Regional biomechanical differences in human ascending aortic aneurysm wall: a paired anterior–posterior analysis

Regional heterogeneity of ascending aortic wall is thought to play a key role in the development of aortic aneurysms. Along the circumference of the vessel, anterior and posterior regions exhibit distinct characteristics. However, intra-patient comparative mechanical data between...

Cyclin/CDK inhibition in cancer therapy: from small molecules and macrocycles to advanced drug delivery systems

Cyclin-CDK complexes have attracted growing interest as therapeutic targets due to their crucial role in cell cycle regulation and their application in cancer treatment. Moreover, although CDKs were considered downstream effectors of the DNA damage response (DDR), several evidenc...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Eco-friendly One-Pot Synthesis of Oxamide

Abstract A novel, eco-friendly one-pot synthesis of oxamide was developed using nontoxic starting materials, offering a safer alternative to traditional methods. The procedure yields a highly pure oxamide precipitate within 2 days. By optimizing key reaction parameters including...

A Thiophilic Metal-Mediated Cysteine S -Detritylation Strategy: Enhancing Orthogonality in Solid-Phase Peptide Synthesis

Abstract The selective manipulation of cysteine residues in solid-phase peptide synthesis (SPPS), beyond disulfide bridge formation, remains challenging, and an efficient protocol for the selective removal of the widely used trityl (Trt) protecting group under solid-phase conditi...

Entropic Phase Separation in Polymer–Vitrimer Melts

Abstract Traditional plastics demand a choice between durability (thermosets) and reprocessability (thermoplastics). Vitrimers are a recent class of polymer network combining both of these qualities. Their increased cost of production can be offset by mixing them with a tradition...

Death in Duisburg: Italian crime fiction and the transnational evolution of a southern archetype

As the first-ever case of a southern Italian mafia exporting its vendetta to another country, the Duisburg massacre of 2007, a conflict involving two rival ‘ndrangheta clans, shocked the European public. Because of its cultural prominence, the incident inspired many cinematic and...

High-fat diet promotes T cell–mediated synaptic dysfunction in multiple sclerosis

Early glutamatergic synaptopathy contributes to disease progression in multiple sclerosis (MS), leading to excitotoxic synaptic damage. Although high-fat diet (HFD)–associated peripheral inflammation has been linked to central nervous system dysfunction, how metabolic and immune...