Federico II University Hospital

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

ABSTRACT Kv7 voltage‐gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally‐expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerati...

In vivo quantification of polyethylene wear in total ankle arthroplasty

Aims In vivo assessment of polyethylene (PE) wear in total ankle arthroplasty (TAA) relies on approximation using 2D metal interspace height (2D-MIH) loss on weightbearing radiographs. Weightbearing CT (WBCT), combined with distance mapping, may improve quantification of PE wear...

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from...

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

ABSTRACT Understanding how peripheral sensory circuits encode mechanical and thermal stimuli requires an experimental system that combines native tissue architecture with high‐resolution electrophysiological readouts. Existing innervated in vitro skin models typically rely on che...

From Structureto Dynamics: Activation Mechanism ofthe G Protein-Coupled Bile Acid Receptor 1-Gs Complex

Abstract The G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) is a key mediator of bile acid signaling, exerting its physiological effects through coupling with the stimulatory G protein (Gs). This interaction stabilizes the receptor’s active state and triggers...

Aphasia treatment research: a decision-making tool to guide the design of phased trials from the Collaboration of Aphasia Trialists (CATs) trials for aphasia panel

Background Systematic reviews of randomised controlled trials with meta-analyses indicate that speech and language therapy for aphasia after stroke is effective in improving communication. However, high-quality evidence to identify an intervention’s target population (who), regim...

Corporate Social Responsibility, Rural Development, and Demographic Sustainability in a Transition Economy

Retaining population is a core condition for the long-term sustainability of rural communities, yet rural out-migration is often treated merely as evidence of local development failure. Agriculturally productive regions may continue to lose population even when output, corporate...

Ultrasound-Guided Retroperitoneoscopic Lumbar Sympathetic Chain Selective Clamping with Indocyanine Green-Assisted Access: A Technical Note

Background: Primary plantar hyperhidrosis is a disabling condition characterized by excessive plantar sweating and impaired quality of life. Lumbar sympathectomy is reserved for patients with symptoms refractory to conservative treatment, but minimally invasive techniques remain...

Engineered PEA-producing Lactobacillus paracasei F19 prevents colitis-associated colorectal cancer in mice by modulating inflammatory–angiogenic signaling and beneficially reshapes gut microbiota composition

Colitis-associated colorectal cancer (CAC) arises from the interplay between chronic inflammation, epithelial dysregulation, angiogenesis, and microbiota alterations. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-angiogenic properties...

Therapeutic Music as a Neuroimmune–Metabolic Modulator in NAFLD: A Spleen‑Centered Working Hypothesis

Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated steatotic liver disease, is frequently accompanied by depression and chronic psychological stress that can worsen metabolic dysfunction, promoting NAFLD progression. Given the current lim...

Disentangling theFluorescence Origin in Flame-FormedCarbon Dots

Abstract Flame synthesis provides a sustainable and continuous route for producing carbon dots (CDs) with tunable photoluminescence; however, the fluorescence origin in flame-formed CDs remains poorly understood, limiting their rational design. In the present paper, we elucidate...

A multi-phase reference matching algorithm for bibliometric analysis: design, implementation, and evaluation

Abstract Bibliometric analyses rely on accurate citation counts, yet bibliographic databases routinely contain variant representations of the same cited reference, differing in journal abbreviation style, author name format, punctuation, or metadata completeness, that fragment ci...

Double functionalization in chitosan scaffolds for bone tissue engineering improvement

Abstract Chitosan is a natural polysaccharide produced by the deacetylation of chitin. It has been employed for several biomedical applications since it is biocompatible and biodegradable. In this work, two synthetic peptides were covalently grafted to chitosan to enhance cellula...

Global stability and uniform persistence in an epidemic model with saturating fomite-mediated transmission

Abstract We analyse the global dynamics of a Susceptible–Vaccinated–Exposed–Infected–Recovered (SVEIR) epidemic model with demographic turnover, imperfect vaccination, and two transmission routes: direct host-to-host contagion and indirect transmission via contaminated fomites. I...

Endoscopic and combined approaches in the surgical management of frontal and ethmoidal sinus osteomas: a novel decision-making flowchart

PURPOSE: Paranasal sinus osteomas are benign but potentially symptomatic lesions whose management remains heterogeneous despite recent advances. Choosing between a purely endoscopic or a combined approach can be challenging, particularly for larger lesions. This study aims to pre...

Multimodal Assessment of Tissue Response After Thyroid Radiofrequency Ablation: Clinical, Imaging, Histopathological and Molecular Insights

Background: Ultrasound-guided radiofrequency ablation (RFA) has become an established minimally invasive treatment for selected benign and autonomously functioning thyroid nodules. Although clinical outcomes are well documented, the biological mechanisms underlying tissue remodel...

Does Gut-Endometrial Immunomodulation Promote Pregnancy in IVF Patients with Recurrent Implantation Failure and Chronic Endometritis Following Escherichia coli Nissle 1917?

Background: Recurrent implantation failure (RIF) remains one of the most challenging conditions in reproductive medicine. Although increasing evidence implicates chronic endometritis (CE) and alterations of the endometrial microbiota in impaired implantation, the potential contri...

Regional brain metabolism and metabolic connectivity alterations in corticobasal syndrome assessed with [18F]FDG-PET

PURPOSE: F]FDG-PET) studies have described regional metabolic abnormalities but detailed subcortical and cerebellar structures involvement is less known and metabolic connectivity remains unexplored. This study combined voxel-based, region-of-interest (ROI) analyses and connectiv...