Amsterdam Neuroscience

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

P1.174. Fluorescence Guided Lymph Node Dissection Using Indocyanine Green During Minimally Invasive Esophageal Cancer Surgery [IGLO] - Pilot-Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Standardization of lymphadenectomy extent in esophageal cancer surgery is complex due to the heterogenous lymphatic drainage patterns. Fluorescence guided lymph node dissection using...

P1.175. Lymph Node Assessment of the Thoracic Duct and Surrounding Compartment in Esophageal Cancer Surgery – the TUPEC Pilot-Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Standardization of thoracic duct (TD) management during esophageal cancer surgery remains controversial. TD resection has been hypothesized to enhance oncologic radicality, since it may increase...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

An ecosyndemic framework for understanding obesity: Spatial clustering of health, environmental and socioeconomic disadvantage in the Netherlands

Abstract Introduction Obesity and related health conditions are unevenly distributed across neighborhoods, often co-occuring with multiple health challenges and socioeconomic disadvantages. Using an ecosyndemic framework, which integrates ecological and social dimensions that con...

The Dutch Prolactinoma Cohort Studies: Cross-sectional Analysis of Females Focusing on the Patient's Perspective

Abstract Purpose To assess the results of patient-reported outcome measures (PROMs) in a national cohort of females with a prolactinoma by disease activity. Methods Females with prolactinoma included in the PRolaCT or ProlaC study were assessed cross-sectionally, comparing patien...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

Bronchiectasis as an Underrecognized Extraintestinal Manifestation of Inflammatory Bowel Disease

ABSTRACT Introduction Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract, often presenting with extraintestinal manifestations (EIMs). The most prevalent pulmonary EIM is IBD‐associated bronchiectasis (IBD‐BE), which is often overloo...

Concordance between plasma biomarkers of phosphorylated tau and tau-PET: A narrative review

Plasma phosphorylated tau (p-tau) and tau positron emission tomography (PET) are key biomarkers for detecting tau pathology in Alzheimer's disease (AD), offering both diagnostic and prognostic value. However, the concordance between plasma p-tau (p-tau217/p-tau181/p-tau231) posit...

Interobserver and intraobserver variability of fetal and maternal Doppler measurements: systematic review and meta‐analysis

ABSTRACT Objectives To evaluate the variability and reproducibility of umbilical artery (UA), fetal middle cerebral artery (MCA) and uterine artery (UtA) Doppler ultrasound measurements in pregnancy. Methods A systematic search of MEDLINE, EMBASE and the Cochrane Library (CENTRAL...

Measuring healthcare quality in police custody: the development of quality indicators through expert consultations in the Netherlands

Abstract Background Improving the quality of care for people detained in police custody requires careful measurement and monitoring. However, a standardized and endorsed set of quality indicators for healthcare in police custody settings is lacking. This study aimed to develop a...

Quantitative biochemical profiling of GCase activity and α-synuclein proteoforms in post-mortem human brains from GBA-related and idiopathic Parkinson’s disease

Variants in GBA1 , encoding lysosomal glucocerebrosidase (GCase), are risk factors for Parkinson’s disease (PD), which is characterized by α-synuclein (αSyn) accumulation and lysosomal dysfunction. Nonetheless, the relationship between αSyn accumulation and GCase deficiency remai...

A literature overview of age- and Tanner stage-specific reference intervals for sex hormones for children aged 0 – 18 years

Abstract Study objective This study aims to provide a comprehensive overview of age- and Tanner stage-specific reference intervals (RIs) for testosterone, estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in children...

Transcranial alternating current stimulation as treatment for delirium: A multicenter randomized double-blind sham-controlled pilot study on safety and feasibility

Delirium is an acute neuropsychiatric syndrome with currently no effective treatment. The acute encephalopathy underlying delirium is characterized by diffuse oscillatory slowing on electroencephalography (EEG). Based on its capacity to modulate oscillatory activity, 10 Hz transc...