Kantonsspital Baden

Uniportal Versus Biportal Endoscopic Unilateral Laminotomy for Bilateral Decompression in Lumbar Spinal Stenosis: A Structured Debate and International Practice Patterns

Lumbar spinal stenosis is a common degenerative disorder that may cause neural compression, neurogenic claudication, radicular pain, and disability, particularly in the elderly; surgical decompression is established when conservative care fails. Endoscopic unilateral laminotomy f...

Oncogene-driven genomic profiles are linked to poor overall survival in muscle-invasive bladder cancer (MIBC)

Abstract Purpose Muscle-invasive bladder cancer (MIBC) is a genomically complex disease with limited biomarkers for predicting patient outcomes. This study aimed to identify molecular correlates of overall survival in MIBC through comprehensive genomic profiling. Methods Tumor DN...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation

Importance: Pulmonary vein isolation (PVI) is less effective in persistent than in paroxysmal atrial fibrillation (AF). Objective: To determine whether adding posterior left atrial wall isolation (PWI) to pulsed field ablation (PFA)-based PVI reduces atrial tachyarrhythmia in pat...

From malpractice to patient safety: A framework for analysing harmful events, system vulnerabilities, and adaptive surgical expertise in neurosurgery – A Swiss perspective

Background The assessment of medical malpractice has traditionally focused on legal responsibility and individual accountability. However, legal classifications may provide only limited insight into mechanisms leading to patient harm and may therefore not fully support the develo...