German Centre for Cardiovascular Research

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

BACKGROUND AND PURPOSE: Myeloid cell leukaemia-1 (MCL-1) is an essential anti-apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL-1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardioto...

Sigh ventilation versus conventional protective ventilation in cardiac surgery: a proof-of-concept randomized controlled trial

Lung protective ventilation is crucial for preventing ventilator-induced lung injury in cardiac surgery. The protective role of a low tidal volume (V T ) has been established, whereas the added protection afforded by lung recruitment remains uncertain. We investigated whether sig...

Histological aging signatures for monitoring tissue-specific aging and disease

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types acro...

CMR-based aortic stiffness parameters in a symptomatic high risk obstructive sleep apnea cohort: results from the population-based Hamburg City Health Study

Abstract Background Aortic stiffness (AS) parameters as pulse wave velocity (PWV), aortic distensibility of the ascending and descending aorta (AD AoAsc, AD AoDesc) and pulse pressure (PP) are marker for vascular ageing, whereas data concerning obstructive sleep apnea (OSA) in po...

Acute kidney injury and renal replacement therapy: a critical synthesis of metabolic derangements and nutritional implications

Acute kidney injury (AKI) affects up to 50% of critically ill patients and is frequently complicated by severe metabolic derangements, requiring the initiation of replacement therapy (RRT) in 10–15% of cases. Despite substantial progress in the diagnosis of AKI and optimisation o...

Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents

Bioresorbable stents (BRS) have been explored in cardiovascular intervention to provide temporary mechanical support while reducing long-term foreign material. The coronary experience has shown both the potential and the limitations of this strategy. First-generation polymeric st...

Tirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study

Abstract Objective To estimate the magnitude of reduction in major adverse cardiovascular events (MACE) that would be observed in clinical practice from adding tirzepatide to standard of care treatment. Design Population based cohort study, using a design, data, and analytical ap...

Reproducible analysis and structured dataset for "Toward clinical-grade deep learning in coronary angiography: a systematic review"

This record contains the structured dataset and analysis code accompanying the systematic review "Toward clinical-grade deep learning in coronary angiography". The dataset comprises extracted study characteristics and quality appraisal results for the included studies, together w...

Investigating changes in the blood-brain barrier in schizophrenia spectrum disorders: design and methodology of a longitudinal dynamic contrast-enhanced MRI study

Schizophrenia spectrum disorders (SSDs) are clinically and biologically heterogeneous and lack reliable biomarkers for stratification, treatment response and course prediction. Evidence from postmortem, fluid biomarker, and neuroimaging studies suggests that changes in the blood-...

Webinars about child and adolescent psychiatry can support professionals in war-affected regions: lessons from the ESCAP-Ukraine webinar initiative

War has a profound impact on child and adolescent mental health and service provision. This requires creative internationally supported response to strengthen professional capacity in trauma care, psychosocial support and evidence based clinical practice in child and adolescent p...

From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation

The persistent shortage of human organs for transplantation has intensified efforts to develop alternative sources, specifically xenotransplantation and exogenesis. Xenotransplantation uses genetically engineered pigs to provide organs, tissues, and cells for clinical use. Signif...

Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice

Orphan GPCRs of the GPRC5 family regulate macrophage activity and vascular contractility by dimerizing with other GPCRs, but pharmacological modulation of this process has not been explored. We previously identified the dimerization interface of receptor GPRC5B and show here that...

β1- and β2-adrenergic receptor mediated spontaneous contractions and ryanodine receptor channel opening in human failing heart

Abstract In heart failure, β-adrenergic receptor (β-AR)-Gsα-cAMP-protein kinase A (PKA) signalling predisposes to delayed-afterdepolarisation-mediated arrhythmias. Phosphodiesterases (PDEs) hydrolyse cAMP, and PDE3 restrains β 1 -AR, β 2 -AR-mediated inotropic responses in failin...