Medical University of Vienna

Optic nerve head blood flow autoregulation during isometric exercise in primary open‐angle glaucoma assessed by laser speckle flowgraphy

Abstract Purpose To assess optic nerve head blood flow (ONHBF) autoregulation in patients with early‐ to moderate‐stage primary open‐angle glaucoma (POAG) and age‐ and sex‐matched healthy controls using laser speckle flowgraphy (LSFG) and isometric handgrip exercise. Methods In t...

How transgender, gender diverse (TGD) and cisgender youth cope with daily stress: Insights from an Ecological Momentary Assessment Study

This study investigated gender minority stress (GMS), coping, and mental health in trans, gender diverse (TGD) and cis youth in Germany and Austria and explored immediate effects of coping on stress in daily life. A 14-day Ecological Momentary Assessment (EMA) study containing th...

Breast Cancer Knowledge and Screening Barriers Among Female University Students of Pakistan

Breast cancer is a leading public health concern among low- and middle-income countries, primarily due to inadequate knowledge and lack of early detection practices. This study aimed to assess knowledge about the signs and symptoms, risk factors, and screening procedures for brea...

Malaria Transmission Via Needle Stick Injury

We present the case of an 11-year-old boy with severe Plasmodium falciparum malaria, whose attending doctor sustained a needle stick injury (NSI) during phlebotomy. We also report the findings of a systematic literature review of papers describing malaria transmission to healthca...

VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1

Abstract Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remain poorly understood. By screening previously uncharacterized proteins induced during the chloroplast unfolded protein respon...

Screening for amyloidosis in trigger finger release and Dupuytren’s fasciectomy

INTRODUCTION: This study investigated the prevalence of amyloid deposition in tissue obtained during trigger finger release and limited fasciectomy for Dupuytren's disease and whether these procedures may allow early detection of cardiac amyloidosis. METHODS: This prospective, ex...

Histological aging signatures for monitoring tissue-specific aging and disease

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types acro...

Evolving Strategies in Pediatric Cataract Surgery: A 7-Year Analysis of Ocular Biometry and IOL Localization

Objectives: To evaluate temporal trends in ocular biometrics, patient demographics and surgical strategies for intraocular lens (IOL) localization in pediatric cataracts. Methods: This retrospective study included 291 eyes of 148 pediatric patients operated at a tertiary referral...

Embryo–Fetal Development and Maternal–Fetal Exposure of the Von Willebrand Factor Binding Aptamer Rondaptivon Pegol (BT200) in Rabbits

Rondaptivon pegol (BT200) is a PEGylated RNA aptamer that prolongs von Willebrand factor (VWF) and factor VIII half-lives in patients with hemophilia A and von Willebrand disease (VWD) type 2B. Embryo–fetal safety is particularly relevant given the disproportionate disease burden...

Subgroup variations in effectiveness of femoropopliteal sirolimus versus paclitaxel-coated balloon angioplasty: post hoc results of the randomised SIRONA trial

INTRODUCTION: The randomised SIRONA trial showed that sirolimus-coated balloon (SCB) angioplasty was non-inferior to paclitaxel-coated balloon angioplasty (PCB) regarding femoropopliteal primary patency. There was no difference in clinically driven target lesion revascularisation...

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

Lysosomes are dynamic organelles regulating metabolic signaling by recruiting cytosolic molecules to protein platforms on their limiting membrane. We used proximity labeling to define interactors and vicinal proteins of LAMTOR3, a component of the Ragulator scaffold that controls...

Uncovering Individual Language Vulnerability in Epilepsy Through Functional Connectivity Laterality

Abstract Background Language processing is organized in brain networks, generally lateralized to the left hemisphere. In clinical routine, task-based functional MRI (fMRI) is the gold standard for non-invasive evaluation of language lateralization. However, standard fMRI does not...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Course of Portal Hypertension and Its Prognostic Impact After Liver Transplantation

ABSTRACT Background While portal hypertension (PH) typically resolves after liver transplantation (LT), persistence of PH may affect post‐transplant outcomes. We assessed the evolution of PH after LT and its impact on adverse outcomes. Methods We recorded clinical, laboratory, an...

Nutritional intake and growth in very low birth weight infants: a comparison of standardized versus parent-led complementary feeding

Abstract The complementary feeding (CF) period is critical for ensuring adequate nutrient intake to support optimal growth in very low birth weight (VLBW) infants. This analysis compares nutritional intake and growth across two CF strategies: a standardized, protocol-driven appro...

Biomechanical properties of an all-soft tissue quadriceps tendon autograft compared with a quadrupled semitendinosus autograft: a cadaveric study

Abstract Background Anterior cruciate ligament (ACL) injuries are among the most frequent ligament injuries, with autograft reconstruction considered to be the gold standard treatment. The all-soft-tissue quadriceps tendon (ASTQT) autograft has gained popularity because of its fa...

Community engagement in epidemics – experiences from the SoNAR-Global COVID-19 vulnerability assessment

Since the largest outbreak of Ebola Virus Disease 2014–2016, the concept of community engagement (CE) gained popularity in global frameworks and strategies to tackle infectious disease. Recent studies suggest that CE might be a useful approach to understand and resolve vulnerabil...

A second yearly booster dose of the VLA15 Lyme borreliosis vaccine candidate in healthy individuals

Human vaccines against Lyme borreliosis, the most common tick-borne illness in Northern Hemispheric temperate climates, remain unavailable. Previous evaluations demonstrated the safety and immunogenicity of primary and booster dosing with VLA15, an investigational vaccine contain...

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay

Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...