Medical University of Vienna

Volumetric Wear of Highly Cross-Linked Polyethylene Sockets in Total Hip Arthroplasty Differs Among Brands: A Retrieval Study

Outcomes after total hip arthroplasty (THA) remain limited by wear and wear particle reaction. Although highly cross-linked polyethylene (HXLPE) mitigated this issue, there are major differences among the various brands available. This study quantified, for the first time, the vo...

Chimeric Antigen Receptor T‐Cell Therapy in T Cell/Histiocyte‐Rich Large B‐Cell Lymphoma: A Systematic Review and Meta‐Analysis

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare subtype of B-cell non-Hodgkin lymphoma with an aggressive clinical course and poor prognosis in the case of relapsed or refractory (r/r) disease. Recently, anti-CD19 chimeric antigen-receptor (CAR) T-cell therapy ha...

Preoperative Injection of Botulinum Toxin Into the Sphincter of Oddi Does Not Prevent Pancreatic Fistula After Distal Pancreatectomy: The Randomized Controlled PREBOTPilot Trial

OBJECTIVE: To investigate whether preoperative injection of botulinum toxin (BTX) into the sphincter of Oddi (SO) is a safe and feasible strategy to prevent postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). SUMMARY BACKGROUND DATA: POPF remains a common an...

Comparison of Biometric Measurements Between Anterior Segment Hyperparallel and Swept-Source Optical Coherence Tomography

Purpose: To evaluate the inter-device agreement between hyperparallel optical coherence tomography (HP-OCT) and swept-source OCT (SS-OCT) in quantitative anterior segment parameters. Methods: Phakic subjects aged ≥40 years were consecutively recruited at a tertiary eye hospital....

‘Building the atomic clinic’: nuclear research in medicine after the Second World War – an introduction

This introduction to the special issue re-examines the emergence of nuclear medicine within a global and transdisciplinary framework. Moving beyond canonical narratives centred on technical breakthroughs and early U.S. developments, it highlights the field's development through t...

Reported practice patterns in the use of local antibiotics for fracture-related infection among SICOT respondents: an international survey

Abstract Background Local antibiotics are increasingly used in the management of fracture-related infection (FRI), but international practice patterns regarding their indications, antibiotic selection, and application methods remain heterogeneous and insufficiently standardised....

Regional Brain Injury Burden on Term-Equivalent MRI Is Associated with Neurodevelopmental Outcome in Extremely Preterm Infants with Intraventricular Hemorrhage

Background/Objectives: Extremely preterm infants remain at high risk of adverse neurodevelopmental outcomes, particularly in the presence of intraventricular hemorrhage (IVH) and associated brain injury. Term-equivalent cerebral magnetic resonance imaging (cMRI) provides a detail...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Vascular device practices in extremely preterm infants: an international cross-sectional survey

Abstract Objective To explore global practices in vascular device selection, securement, and monitoring for extremely preterm infants, and to assess regional variation. Study design A web-based cross-sectional survey was completed by one respondent per neonatal unit. Result We re...

Impact of retinal break location on surgical outcomes in primary uncomplicated rhegmatogenous retinal detachment: Superior versus inferior breaks

Abstract Purpose To compare the anatomical and functional outcomes of pars plana vitrectomy (PPV) for primary uncomplicated rhegmatogenous retinal detachment (RRD) with superior versus inferior retinal breaks. Methods This retrospective study included 675 eyes of 675 patients, of...

Zanidatamab: reshaping the treatment landscape for HER2-positive gastroesophageal adenocarcinoma

Summary HER2 testing is essential in the pathological workup of metastatic gastroesophageal adenocarcinoma (GEA). Zanidatamab is a bispecific IgG1-like antibody that targets extracellular domains 2 and 4 of HER2 in a trans configuration. This biparotopic binding promotes receptor...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

Gut resilience and clinical homeostasis following administration of neomycin and albendazole in soil-transmitted helminth-infected adults living in Lambaréné, Gabon

Abstract Purpose Gut resilience and systemic homeostasis are interrelated dynamic functions. A gut that fails to regulate intestinal barrier integrity, metabolite production, and immune regulation will lead to systemic pathogenic invasion and susceptibility to infections. Gut res...

Neural Regeneration After Supercharged End-to-Side Nerve Transfer: Which Way to Go?

BACKGROUND AND OBJECTIVE: The exact regeneration pattern and directional fiber distribution of donor axons within the recipient nerve after supercharged end-to-side nerve transfer (SETS NT) over time still remains elusive. This study aimed to investigate whether axons preferably...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

Validation of the European Bone & Joint Infection Society recommendations for debridement, antibiotics, and implant retention in hip and knee periprosthetic joint infection

Aims The aim of this study was to externally validate the European Bone & Joint Infection Society (EBJIS) recommendations for the use of debridement, antibiotics, and implant retention (DAIR) in the treatment of periprosthetic joint infection (PJI), examining the independent asso...

Acceptance of Organs From Deceased Donors: Results of a Global Survey.

Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We assessed knowledge and com...

The global cost of schizophrenia: a health economic modelling study

Abstract Background Schizophrenia is a chronic psychiatric disorder that leads to substantial disability, impaired quality of life, and reduced life expectancy. In addition to its profound impact on affected individuals, the disorder places a considerable financial burden on heal...

Brainstem size in extremely preterm infants: reference values and association with neurodevelopmental outcomes

Abstract Background and objectives Extremely preterm infants are at high risk for neurodevelopmental impairment. The brainstem plays a critical role in early development. This study aimed to establish reference values for two-dimensional brainstem measurements on cerebral magneti...

Development of a prospective clinical workflow for proton beam therapy of ventricular tachycardia

Abstract Purpose This study presents a prospective preclinical workflow for proton beam therapy of refractory ventricular tachycardia (VT), covering target transfer, treatment planning (TP), and beam gating. Methods Photon-based stereotactic arrhythmia radioablation (STAR) protoc...