University of Zurich

WISH-barcoding of Salmonella Typhimurium ATCC14028s strains for population dynamics studies in vivo

Background Barcoding of isogenic strains is a powerful approach to assess pathogen population dynamics during infection. Here, we adapted WISH-barcoding to Salmonella Typhimurium ATCC14028s to evaluate its suitability for pooled infection experiments in streptomycin-pretreated mo...

Protocol for a cluster randomized controlled trial among young people and their peers to reduce substance use and inequitable gender beliefs in Southern Africa

BACKGROUND AND AIMS: Substance use and the internalization of traditional gender norms, or inequitable gender beliefs, are co-occurring risk behaviors for poorer health and well-being in young people in Southern Africa. Addressing the social and structural factors that reinforce...

Microsurgical Lymphovenous Anastomosis for the Treatment of Central Lymphatic Flow Disorders in Children and Adults

Central lymphatic flow disorders remain a significant diagnostic and therapeutic challenge. Treatment typically follows a stepwise escalation approach, with reconstructive surgery being employed mainly in patients in whom conservative and interventional methods have failed or are...

Recognition Loop Dynamics Differentiates m6A-mRNA Reader Domains of YTHDF Proteins

Abstract The three human YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) are highly homologous and recognize the N6-methyladenosine (m6A) modification of mRNA with essentially identical binding modes and affinities. This homogeneity challenges the well-established view th...

Silyl Chloroalkenyl and Alkynyl Sulfur Pentafluorides as Versatile Reagents to Access Fundamental SF5 Building Blocks

Abstract Herein, we report a second-generation SF5-alkenyl platform reagent granting facile benchtop access to a variety of known and unknown SF5-containing building blocks under mild conditions without any necessity to use pentafluorosulfanylation reagents, such as SF5Cl, on-sit...

Accuracy of visual estimation of coronary artery calcifications on low-dose CT from oncologic FDG PET/CT

To evaluate the feasibility and accuracy of visual ordinal coronary artery calcium (CAC) scoring on low-dose, non-gated CT scans acquired as part of oncologic PET/CT, using CAC scoring from ECG-gated non-contrast cardiac CT as the reference standard. 210 oncological patients who...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...

AI-generated language remains systematically distinguishable from human communication

Large language models (LLMs) are increasingly used in the social sciences to simulate human behavior and communication, yet validation methods for these applications remain limited. Existing evaluations often rely on human judgments of plausibility, a coarse, difficult-to-scale,...

A supergene and genomic mosaicism are associated with phenotypic evolution in Galápagos tree finches

Abstract Adaptive radiations provide powerful models to study the origins of phenotypic novelty and species diversity. Darwin’s finches constitute a classic example of adaptive radiation, in which beak morphology is a key trait related to fitness. Here, we focus on Camarhynchus t...

Effect of Crestal Soft‐Tissue Augmentation Prior to or Simultaneously With Implant Placement on Peri‐Implant Tissue Dimensions: Histological Outcomes of an Experimental In Vivo Study

ABSTRACT Aim To histologically assess the effect of the timing of soft‐tissue augmentation (prior to or simultaneously with implant placement) and the type of grafting material on peri‐implant soft‐tissue dimensions. Materials and Methods Mandibular molars (M1, M2, M3) were bilat...

Chronic alanine aminotransferase elevation in people with HIV : Time trends over 22 years and genetic predisposition

Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was d...

An update on neuro-otology and neuro-ophthalmology – focusing on new developments in the last three years

Vertigo, dizziness, and imbalance are among the most frequent presenting symptoms in primary care and in the emergency department (ED). The clinical diagnosis is based on a structured patient history and bedside examination of the vestibular system and the ocular motor system, lo...

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

ABSTRACT Biotherapeutics are required to achieve high remission rates in patients with severe ulcerative colitis (UC); however, adverse effects, complex dosing regimens, administration routes, and low patient compliance limit their widespread clinical use. Given the localized nat...

From protogalaxy through thick and thin: Why did the Milky Way evolve in three kinematic phases?

Abstract APOGEE and Gaia data suggest the Milky Way’s kinematic structure evolved through three distinct phases: a disordered protogalaxy, which ‘spun up’ into a thick stellar disk, and then ‘cooled down’ to a final cold, thin stellar disk. We use a suite of FIRE-2 cosmological z...

Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting

Background Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high‐sensitivity cardiac troponin (hs‐cTn). cMyC (cardiac myosin‐binding protein C), because of its fas...

Regio- and Enantioselective Functionalization of Gaseous Alkanes via Nickel-Catalyzed Alkene Dicarbofunctionalization

Abstract The regio- and enantioselective functionalization of gaseous alkanes remains an unsolved challenge in organic synthesis. Here, we report a general strategy for the asymmetric three-component dicarbofunctionalization of alkenes using readily available gaseous alkanes, inc...

Antenna subtraction at NNLO for heavy quark pair production at hadron colliders: the non-diagonal channels

A bstract We present the calculation involving the qq , qq ′ and qg partonic channels contributing to heavy-quark pair production at hadron colliders through next-to-next-to-leading order in QCD using the antenna subtraction formalism. The calculation is performed in full colour...

Reported practice patterns in the use of local antibiotics for fracture-related infection among SICOT respondents: an international survey

Abstract Background Local antibiotics are increasingly used in the management of fracture-related infection (FRI), but international practice patterns regarding their indications, antibiotic selection, and application methods remain heterogeneous and insufficiently standardised....

A Multinational Study of Orientation-Aware Deep Learning for Automated Detection of Retained Roots and Periodontal Bone Loss

Introduction and aims Accurate radiographic assessment of retained roots (RR) and periodontally compromised teeth (PCT) are critical for dental diagnosis. This study aimed to develop and evaluate deep learning models for the automated detection and classification of these patholo...

At what cost? Governing unity in Tibetan diaspora nationalism

This article examines Tibetan exile politics as a form of long-distance nationalism unfolding within a deterritorialized arena linking homelands, host states, and global solidarity networks. While diasporas are often portrayed as cohesive political actors, Tibetan exile politics...