Latest articles

Abstract editorial illustration accompanying the article: Study finds frequent inappropriate ulcer-prevention medicine use in Ethiopian ICUs
Health & Medicine
Low evidenceHuman study

Study finds frequent inappropriate ulcer-prevention medicine use in Ethiopian ICUs

Researchers studied stress ulcer prophylaxis—medicines intended to reduce the risk of stomach ulcers or bleeding—among 229 critically ill patients in three public hospital ICUs in Addis Ababa, Ethiopia. In this prospective observational study, inappropriate use was reported during admission, the ICU stay and at discharge. The findings describe prescribing patterns in these hospitals and do not prove that any patient outcome was caused by the medicines or by their inappropriate use.

·28 views
Abstract editorial illustration accompanying the article: Review examines targeted immune-cell treatments in stomach and junction cancers
Health & Medicine
High evidenceReview

Review examines targeted immune-cell treatments in stomach and junction cancers

This systematic review examined seven early-phase human studies of treatments directed at the CLDN18.2 protein in gastric and gastroesophageal-junction cancers. Across 396 mostly previously treated patients, the studies reported tumor responses and frequent but generally low-grade cytokine release syndrome; the researchers said the results need confirmation in randomized trials.

·56 views