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Abstract editorial illustration accompanying the article: A brain-cell map shows how disease-linked genes are regulated

A brain-cell map shows how disease-linked genes are regulated

Researchers created a high-resolution map of genetic regulation in the human prefrontal cortex using 5.6 million nuclei from 1,384 donors. The atlas revealed cell-specific regulation of genes linked to brain disorders that bulk-tissue studies had not detected.

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Abstract editorial illustration accompanying the article: When development projects fail, more brokers emerge in remote Papua New Guinea

When development projects fail, more brokers emerge in remote Papua New Guinea

Research on Febi and Kubo people in Papua New Guinea’s Western Province describes a history of incomplete projects, wasted money and development brokers who have not delivered lasting progress. As earlier brokers fell short, new generations emerged, connecting communities to government, financial and service systems while also deepening dependence on personal networks.

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Abstract editorial illustration accompanying the article: New analysis finds small QTc changes with some antidepressants early in treatment
Health & Medicine
High evidenceReview

New analysis finds small QTc changes with some antidepressants early in treatment

Researchers analysed double-blind randomised trials of adults with major depressive disorder to compare 10 antidepressants with placebo during the first eight weeks of treatment. Some medicines were associated with longer QTc intervals, a heart rhythm measurement, but the analysis did not find higher rates of early major cardiovascular events or non-suicidal death compared with placebo.

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Abstract editorial illustration accompanying the article: A brain atlas maps shared and distinct changes across eight disorders

A brain atlas maps shared and distinct changes across eight disorders

Researchers analyzed more than 6.3 million nuclei from the dorsolateral prefrontal cortex of 1,494 donors, including people with eight brain disorders and neurotypical controls. The atlas shows shared cellular changes across diseases, as well as disease- and stage-related differences in Alzheimer’s disease.

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