University of Toronto

Severe mental illness in the MENAT region: systematic review and meta-analysis of prevalence and comorbidities

Abstract Background Severe mental illnesses (SMIs), including schizophrenia spectrum disorders, bipolar disorders, and severe major depressive disorder (MDD), contribute substantially to disability and premature mortality worldwide. Evidence from the Middle East, North Africa, an...

Co-designing a financial navigator program in the neonatal neurodevelopmental follow-up clinic: a formative mixed-methods study

Families of infants requiring neonatal intensive care often experience substantial financial hardship due to income loss and out-of-pocket costs during hospitalization and after discharge. Hospitals currently lack dedicated, structured support to help families navigate these fina...

Surmountable Caregiver Barriers to Paratonia Treatment in Community-Dwellers with Dementia: A Cross-Sectional Survey

Paratonia is an involuntary, variable resistance to passive movement that affects 90%-100% of patients with advanced dementia, interferes with care and contributes to caregiver burden. Botulinum toxin A is a candidate treatment but has no approved indication, and whether communit...

Predicting Angle Beam Ultrasonic Inspection Signals with a Physics-Informed Neural Network

Simulation of angle beam ultrasonic inspection supports procedure qualification, probe design, and defect detectability studies, but conventional solvers require a conforming mesh for each configuration and return the solution only at mesh nodes and discrete time steps. Physics-I...

Genetic Investigation in Fetal Growth Restriction: An Integrated Approach for Clinical Practice

ABSTRACT International guidelines recommend genetic testing when fetal growth restriction (FGR) accompanies structural anomalies, but recommendations for apparently isolated FGR remain variable, particularly regarding gestational age thresholds and the role of exome sequencing (E...

Identifying barriers to cancer screening among people experiencing homelessness: a systematic review

People experiencing homelessness (PEH) face significant health disparities including higher morbidity from chronic diseases such as cancer. Despite the availability of screening programs for breast, colorectal, lung, and cervical cancers, screening availability and participation...

Mixed motives and linear forms in the Catalan constant

Abstract We first give a geometric construction of a two‐dimensional mixed motive over with the Catalan constant as a period. We then use this motive to obtain a supply of linear forms in 1 and . We also explicitly compute the coefficients of 1 and in these linear forms.

Critical point representation of the mutual information in the sparse stochastic block model

We consider the problem of recovering the community structure in the stochastic block model. We aim to describe the mutual information between the observed network and the actual community structure as the number of nodes diverges while the average degree of a given node remains...

Muslim identity, criticism of Israel, and attitudes toward Jews: a test of the new antisemitism thesis

This paper tests two hypotheses of the new antisemitism thesis: (1) criticism of Israel leads to more negative attitudes toward Jews and (2) Muslims are more likely than non-Muslims to have negative attitudes toward Israel and Jews. Analysis of data from a nationally representati...

Counting the number of $2_{n}$-preperiodic integral points of a discrete dynamical system with applications from arithmetic statistics, IX

In this follow-up paper, we inspect a surprising relationship between the set of (strictly) $2_{n}$-preperiodic points of a polynomial map $\varphi_{d, c}$ defined by $\varphi_{d, c}(z) = z^d + c$ for all $c, z \in \mathbb{Z}$ and the coefficient $c$, where $d>2$ is an integer an...

Ethical guidance for randomized controlled trials of donor interventions in deceased organ donation: a scoping review of international guidelines, consensus statements, and expert recommendations

Deceased donor interventions are nontherapeutic interventions to improve the likelihood of successful donation and transplant outcomes. Randomized controlled trials (RCTs) could strengthen the evidence base for donor interventions, but such trials face difficult ethical challenge...

Complex interactions among invasive fishes and flow barriers combine to maintain an endangered native species

Abstract The Breede River in the Western Cape Province is one of South Africa’s major freshwater systems and of high ecological and socio-economic value. Similar to other freshwater systems worldwide, it is threatened by environmental degradation and multiple invasive species. Un...

Clinical Improvement, No Improvement, and Worsening at 24 Hours Following Reperfusion in Patients With Stroke due to Large-Vessel Occlusion

BACKGROUND: Restoring blood flow to ischemic tissue is the cornerstone of acute stroke therapy and is usually beneficial. However, when reperfusion is achieved for severely injured tissue, it is often futile and may occasionally cause harm. We aim to determine the prevalence and...

Software and Systems Modeling journal celebrates its silver anniversary-a look into the future of modeling

Abstract SoSyM has turned 25. You can even see that on the cover of this dedicated issue. The 25th anniversary of Software and Systems Modeling provides an opportunity to look back—not only at the development of our journal, but also at the evolution of the entire scientific fiel...

Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS

Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...

Interoceptive Accuracy, Metacognition, and Facial Trustworthiness Perception Across the Adult Lifespan

Abstract Older adults often exhibit more positive impressions when forming trustworthiness impressions based on facial appearance. These judgements influence social decisions in later interpersonal interactions and are thought to put older adults at greater risk of victimization....

FaceValue: Exploring Real-Time Self-View Overlays to Prompt Meaning-Oriented Self-Awareness in Remote Meetings

In remote video meetings, visual non-verbal cues, such as facial expressions or head movements, are seen continuously but often only partially. This increases ambiguity compared to in-person settings and can cause misinterpretation or misalignment between intended and perceived m...

Adherence to treat-to-target recommendations in juvenile idiopathic arthritis in clinical practice

Abstract Objective To assess adherence to Treat-to-Target (T2T) recommendations for juvenile idiopathic arthritis (JIA) in clinical practice. Methods A nested cohort study in the multicenter international prospective UCAN JIA cohort was performed. Patient characteristics, clinica...

Postoperative thyroglobulin antibodies in differentiated thyroid cancer: predictors and associations with persistent and recurrent disease

Anti-thyroglobulin antibodies (TgAb) are present in up to 25% of patients with differentiated thyroid cancer (DTC) and interfere with thyroglobulin (Tg) measurement, a key biomarker used to monitor for persistent or recurrent disease (PRD). Despite its clinical significance, risk...

The Simons Observatory: Development of a Pipeline to Detect Rapid Transients in Time-Ordered Data

We introduce a method for detecting astrophysical transients evolving on timescales of milliseconds to minutes using cosmic microwave background (CMB) survey telescopes. While previous transient searches in CMB data operate in map space, our pipeline directly processes the raw ti...