University of Toronto

Paired-Fraction Electrochemical Programming for Somatostatin-14 Manufacture: Disulfide Closure under a Tryptophan-Oxidation Constraint

Somatostatin-14 is a 14-residue cyclic peptide closed by a Cys3-Cys14 disulfide and containing an oxidation-sensitive Trp8 residue. This combination makes it a discriminating test of paired-fraction electrochemical programming (PFEP): a useful process must create the disulfide wi...

Predictors of Visual Outcomes in Pituitary Neuroendocrine Tumor Resection

ABSTRACT Objective: We sought to identify clinical and radiologic predictors of visual recovery and explore visual outcomes in patients who underwent transsphenoidal resection of pituitary neuroendocrine tumors (PitNETs). Methods: Retrospective study of patients with PitNETs appr...

Paired-Fraction Electrochemical Programming of Ligase-Mediated Peptide Macrocyclization

A simple head-to-tail cyclic peptide is proposed as the fourth step of a PFEP validation ladder using Omniligase-1, a catalogued recombinant peptide ligase, subject to confirmation of current supply and lot activity. The model precursor is a 14-residue, side-chain-unprotected lin...

Screening for Early Endometriosis Detection (SEED): Co-development of a Symptom-Based Screening Measure for Canadian Young Adults in Primary Care

Background Many Canadians experience prolonged pain, uncertainty, and stigma before receiving an endometriosis diagnosis, with delays averaging 11 years from symptom onset. Endometriosis, defined by the presence of endometrial-like tissue outside the uterine cavity, impacts 10% o...

The impact of non-medical determinants of health on patient-reported outcomes in pediatric lupus: A CARRA registry study

Objectives Social determinants of health (SDOH) and race are associated with disease activity, including lower achievement of the low lupus disease activity state (LLDAS), but it is unknown whether these factors are associated with patient-reported outcomes (PROs). Among a cohort...

Data-driven stochastic reduced-order modelling of parametrized dynamical systems

Abstract Modelling complex dynamical systems under varying conditions is computationally intensive, often rendering high-fidelity simulations intractable. Although reduced-order models (ROMs) offer a promising solution, current methods often struggle with stochastic dynamics and...

The Practice of Social Innovation: The Strategies and Tools of Philanthropic Foundations

Abstract Social innovation promises to deliver social goods more effectively and find new solutions to endemic problems. However, the concept is ambiguous and becoming fuzzier; it is not clear what actors are doing—or how or why—when they engage in social innovation. As a startin...

FoMo: A multi-season dataset for robot navigation in Forêt Montmorency

The Forêt Montmorency (FoMo) dataset is a comprehensive multi-season data collection, recorded over the span of 1 year in a boreal forest. Featuring a unique combination of on- and off-pavement environments with significant environmental changes, the dataset challenges establishe...

High Yield of Pharmacogenetic Testing for Clopidogrel Resistance in a Canadian Outpatient Stroke Population

BACKGROUND: Clopidogrel is commonly prescribed for secondary stroke prevention, but routine pharmacogenetic testing is not typically performed. As the CYP2C19 enzyme activates clopidogrel into its effective form, clopidogrel-treated patients who carry CYP2C19 loss-of-function all...

Smoothing out the edges: continuous-time estimation with Gaussian process motion priors on factor graphs

Continuous-time state estimation is gaining in popularity due to its abilities to provide smooth solutions, handle asynchronous sensors and interpolate between data points. While there are two main paradigms, parametric (e.g., temporal basis functions, splines) and nonparametric...

Retinal Coverage of Combined Intravitreal Tamponade Agents after Pars Plana Vitrectomy Visualized with Orbital Magnetic Resonance Imaging

Purpose: To characterize the behavior of single and combined intravitreal tamponade agents using magnetic resonance imaging (MRI), with emphasis on identifying the most effective materials and postoperative positioning strategies for complex retinal detachments involving both sup...

Analysts’ use of toxic emissions data

Purpose This study examines whether financial analysts function as information intermediaries by incorporating Toxics Release Inventory (TRI) data into their assessments of firms' environmental risks, as reflected in earnings forecasts and stock recommendations. It further invest...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Joint Modeling of GD-1 and C-19 as Old Streams

Abstract DESI observational data for the GD-1 and C-19 streams are compared to stream simulations in an evolving multihalo potential of a Milky Way–like galaxy based on a cosmological Milky Way–like simulation. The number of subhalos decreases with time, and the subhalo-stream en...

Clinical outcomes of primary anterior cruciate ligament reconstruction with concomitant lateral meniscal posterior root tear repair versus isolated anterior cruciate ligament reconstruction: a systematic review and meta-analysis

Introduction Lateral meniscal posterior root tears (LMPRTs) commonly occur with anterior cruciate ligament (ACL) injuries, but clinical outcomes after concomitant repair remain unclear. Aim This systematic review and meta-analysis compared postoperative outcomes after ACL reconst...

Racial and Ethnic Disparities in Birth Weight Measurement Precision

This cross-sectional study explores whether digit preference in neonatal care is associated with racial and ethnic disparities in birth weight measurement.

Consented Universal Newborn Screening for Congenital Cytomegalovirus Infection Using Dried Blood Spot and Dried Saliva Spot Specimens: Implementation and Relative Programmatic Accuracy

The purpose of this research was to evaluate the implementation and relative diagnostic accuracy of dried blood spot (DBS) and dried saliva spot (DSS)-based newborn screening for congenital cytomegalovirus infection (cCMV). This prospective paired-sample pilot studied consecutive...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...

Stable isotope‐derived measurements of protein synthesis detect amino acid‐induced anabolism in skeletal muscle microtissues not captured by puromycin labelling

Skeletal muscle microtissues are valuable in vitro models for studying the stimuli regulating muscle protein synthesis (MPS), the key determinant of changes in muscle mass. Differentiated between opposing posts, microtissues contain aligned, contractile myotubes, providing a cont...

Transforming federal emergency management: a new agenda for Canada

Abstract Canada’s emergency governance model no longer aligns with a risk environment shaped by accelerating climate change and increasingly complex multi-hazard events. Recent federal/provincial/territorial strategies acknowledge these growing pressures but have not materially r...