Institution
University of Toronto
Recent research
- Health & MedicineOpen access
Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...
- Society & EconomicsOpen access
The interplay of digital platforms and sexualized substance use has reshaped Two-Spirit, gay, bisexual, trans, and queer (2SGBTQ) men’s sociality and wellbeing. 2SGBTQ men use digital platforms and sexualized substances at unprecedented rates. The overall aim of this research was...
- Health & Medicine
ABSTRACT Purpose To critically assess artificial intelligence (AI)‐based radiographic models for quantitative measurement, localization/detection, segmentation/keypoints, diagnostic classification, and severity or morphology assessment of peri‐implant marginal bone loss (MBL) and...
- Materials & Energy
Synthesis of a Fully Functionalized Chasmanine AF-Ring Fragment
Abstract C19-Diterpenoid alkaloids (C19 DTAs) represent a large family of structurally and biologically complex natural products. Within this class, C6-oxidized natural products have remained largely unsynthesized. Herein, we report an expedient synthesis of the fully functionali...
- Health & MedicineOpen access
Abstract Background To examine effects of naturally occurring antioxidants on DNA damage repair acute responses of ionizing radiation sustained by interventional physicians during angiography. Methods The study cohort included 20 interventional physicians (19 males, 1 female; mea...
- Health & MedicineOpen access
Blood proteomics of menopause map to brain aging and dementia risk
Abstract Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated wit...
- Materials & EnergyOpen access
The microbial degradation of synthetic polyesters such as polyethylene terephthalate (PET) is mediated by diverse α/β‐hydrolases, many of which remain poorly characterized. In this study, we investigated SM0281, an uncharacterized α/β‐hydrolase from the symbiotic legume‐associate...
- AI & ComputingOpen access
Full mad families of vector spaces and two local Ramsey theories
Let E be a vector space over a countable field of dimension ℵ0. Two infinite-dimensional subspaces V,W⊆E are almost disjoint if V∩W is finite-dimensional. This paper provides some improvements on results of Smythe (2019) about the definability of maximal almost disjoint families...
- BiologyOpen access
Niche occupancy of Jamaican bat caves: Diversity increases isotopic niche packing
There are over 1000 documented caves across Jamaica, many of them used by diverse communities of bats. Species across these communities fit within the same trophic guilds and families and can be found at the same sites, raising the question of how these species can coexist. We ca...
- Biology
Abstract Background : This case study examines the 2025 floods in Nyando Sub-County, Kisumu County, Kenya, and the resulting cholera outbreak that exposed weaknesses in the public health system. Seasonal flooding damaged sanitation facilities, contaminated water sources, and led...
- Health & Medicine
Eye Findings Following Congenital Cytomegalovirus Newborn Screening
BACKGROUND AND OBJECTIVE: Consensus guidelines have recommended eye examinations for all newborns with congenital cytomegalovirus (cCMV) infection; however, structured ophthalmic examinations are seldom reported. Existing literature suggests ocular pathology is uncommon in cCMV,...
- Health & MedicineOpen access
A multi-site loiasis dataset of whole blood videos
Loiasis is a blood-borne filarial infection under consideration for inclusion in the WHO’s priority list of Neglected Tropical Diseases. In addition to its direct impact on human health, loiasis frequently occurs as a co-infection with other filarial diseases, including onchocerc...
- Health & Medicine
Clinical Prediction With Time-Varying Predictors in Pediatric Hospital Medicine
Clinical prediction models traditionally rely on measurements obtained at a single time point to estimate risk and guide management. However, the clinical status of hospitalized children often evolves during admission, and time-varying measurements obtained over the course of hos...
- Engineering & TechnologyOpen access
This paper investigates the atomization of Newtonian liquid sheets and the resulting droplet size distributions in the primary breakup. A conjugate model is proposed that combines Kelvin–Helmholtz instability (KHI) with a sheet perforation mechanism. In this framework, the KHI go...
- Health & MedicineOpen access
ABSTRACT Aims To assess the effect of semaglutide on body composition and physical function. Materials and Methods The phase 3b STEP UP trial randomised adults with body mass index ≥ 30 kg/m 2 to once‐weekly subcutaneous semaglutide 7.2 mg, semaglutide 2.4 mg or placebo for 72 we...
- Materials & EnergyOpen access
Role of Na in determining the properties of sodic glasses
Molecular Dynamics (MD) simulation of Na 4 SiO 4 glass yields Na-O bond distances, and O-Na-O angles remarkably similar to those in sodic crystals, regardless of their compositions. Na polyhedra in both phases are stabilized by a common, formative mechanism, collapse of SiO 4 tet...
- Engineering & TechnologyOpen access
Implementing underground coal gasification (UCG) in post-ECBM reservoirs, namely coal reservoirs after CO 2 -enhanced coalbed methane (CO 2 -ECBM) recovery, provides a potential pathway for residual energy recovery. However, the pre-existing CO 2 -rich environment alters reservoi...
- Health & MedicineOpen access
Trends in opioid containing drug seizures described as pills between 2020 and 2024 in Canada
People who use drugs may access prescription opioids from unregulated markets to avoid fentanyl and lower toxicity risk, though concerns regarding counterfeit pills have emerged. To better understand the composition of pills that may be circulating in the unregulated drug supply,...
- Health & MedicineOpen access
Background The Canadian opioid toxicity crisis has disproportionately harmed First Nation Peoples. We compared opioid agonist treatment (OAT) outcomes within this population. Methods Our population-based cohort included First Nation Peoples in Ontario, Canada, who initiated bupre...
- Health & MedicineOpen access
This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...