University of Toronto

The DESI Y1 RR Lyrae Catalog. II. The Metallicity Dependency of Pulsational Properties, the Shape of the RR Lyrae Instability Strip, and Metal Rich RR Lyrae

Abstract RR Lyrae stars (RRLs) are valuable probes of both Milky Way assembly and stellar-evolution physics. Using a sample 6240 RRLs obtained in the first year of the Dark Energy Spectroscopic Instrument (DESI) survey, we investigate the metallicity of RRLs and its correlation w...

Do Coverage and Mutation Scores of LLM-Generated Test Suites Correlate with Their Effectiveness? (Replicability Study)

Recent advances in large language models (LLMs) have driven growing interest in using LLMs to automate test generation. Prior work commonly evaluates generated test suites using proxy metrics such as code coverage and mutation score. However, studies by Inozemtseva et al. and Pap...

Extreme values of class group L‐functions

Abstract We give a lower bound for the maximum value of class group ‐functions attached to at the central point and show that this value is on average at least for any .

Towards Wearable Opportunistic Crowdsensing for Open-Vocabulary Activity Data Collection Through User-Scheduled Trigger-Action Routines

Collecting richly labeled wearable activity data in everyday settings remains difficult because retrospective annotation is costly and often imprecise. Prior data collection apps rely on a labor-intensive self-reporting strategy and primarily treat participants as crowd labelers....

Hematologic Malignancy Prevalence in Hidradenitis Suppurativa: A Cross-Sectional Study

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with substantial comorbidity. Evidence regarding the co-occurrence of HS and recorded hematologic malignancy diagnoses in large, diverse electronic health record populations remains limite...

A Thermoreversible Gelation Pathway to Plant Cuticle‐Inspired Biopolymer Aerogel Monoliths Based on Network‐Spherulitic Crystal Assemblies

ABSTRACT Plant‐based and compostable biopolymers are vital in global shifts toward green materials. However, their adoption in aerogel fabrication is limited by material and structure‐performance deficiencies (e.g., hydrophilicity, low surface area, brittleness, limited tactile t...

Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.

Oral squamous cell carcinoma (OSCC) often arises from oral epithelial dysplasia (OED); however, the gene expression changes during OED progression and its microenvironment are not fully understood. This study used spatial transcriptomics to identify differentially expressed genes...

Gender disparities in leadership of methodological research in health science

Objectives Gender disparities in methodological studies are largely unexplored. We aimed to examine gender representation between first and last authorship positions in methodological research in health science. Methods We searched for methodological articles as part of a large s...

The Long-Term Effects of Cash Assistance

We investigate the long-term effects of cash assistance on beneficiaries and their children among participants in the Seattle-Denver Income Maintenance Experiment. Treated families in this randomized experiment received thousands of dollars in extra government benefits for three...

Land, Gendered Labor, and Empire‐Making in Central Sudan

ABSTRACT This article offers an ethnographic analysis of Gulf Arab empire‐making in central Sudan, focusing on an Emirati‐owned farm in the Gezira region as a key site of capitalist extraction and imperial ambition. Through three overlapping vantage points—farm, port, and body—it...

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site

ClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered by paradoxical activation...

Money, Time, and Grant Design

We conduct survey experiments to test how the design of scientific grants—the money and time awarded—can be used to manage researchers. On average, researchers are relatively unwilling to trade off money for time when choosing among grants. However, there is significant heterogen...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Divergent expression and conserved function of Alx4 for limb development in amniotes

Morphological diversification among amniote limbs is widely thought to arise through evolutionary changes in developmental gene regulation, yet whether divergent gene expression is accompanied by divergence in developmental function remains unclear. Here, we examined this questio...

Don't Lead with Climate, Lead with Local Aspirations: Fostering Meaningful Community Engagement in Toronto

Abstract Achieving the very ambitious climate action goals of cities with net zero GHG emissions targets will require unprecedented levels of political support and behavioural engagement from residents. Climate engagement methods adopted by most cities typically consist of public...

Assessing residual bias in real-world vaccine effectiveness studies: validating negative controls to avoid misleading results

Observational studies and randomized controlled trials demonstrate that vaccines protect against infections and severe outcomes, but real-world vaccine effectiveness estimates remain vulnerable to residual biases. Negative control outcomes can help detect and mitigate such biases...

Clinical, biochemical and genetic spectra of carnosinemia: a systematic review of case reports and case series

Abstract Carnosinemia, also referred to as carnosinase 1 (CNDP1) deficiency, is an ultra-rare inborn error of metabolism characterized by impaired CNDP1 activity and carnosine degradation. The clinical significance and phenotypic spectrum of this condition remain poorly defined,...

Firearm owners’ support for policies regulating firearms left in vehicles

Abstract Purpose Firearms stolen from vehicles are a leading source of gun theft in the US. In response, there has been growth in the number of proposed and enacted policies at the state and local levels. Yet firearm owners’ attitudes toward policies regulating firearms left in v...

Severe mental illness in the MENAT region: systematic review and meta-analysis of prevalence and comorbidities

Abstract Background Severe mental illnesses (SMIs), including schizophrenia spectrum disorders, bipolar disorders, and severe major depressive disorder (MDD), contribute substantially to disability and premature mortality worldwide. Evidence from the Middle East, North Africa, an...

Reconsidering the Alberta study of the closure of the Red Deer supervised consumption site

Supervised consumption sites (SCS) are interventions supported by decades of evidence and yet remain subject to considerable politicization. Recently, researchers from Alberta, Canada published a study in the journal Addiction that sought to assess the impacts of the closure of a...