University of Toronto

Stable isotope‐derived measurements of protein synthesis detect amino acid‐induced anabolism in skeletal muscle microtissues not captured by puromycin labelling

Skeletal muscle microtissues are valuable in vitro models for studying the stimuli regulating muscle protein synthesis (MPS), the key determinant of changes in muscle mass. Differentiated between opposing posts, microtissues contain aligned, contractile myotubes, providing a cont...

The chicken or the egg? Unravelling the role of vascular remodelling in HFpEF

Heart failure with preserved ejection fraction (HFpEF) is a multi-organ syndrome in which symptoms of heart failure occur despite a preserved ejection fraction (≥50%).Impaired ventricular relaxation and elevated filling pressures, particularly during exertion, contribute to dyspn...

A longitudinal Bayesian framework for estimating causal dose-response relationships

Existing causal methods for time-varying exposure and time-varying confounding focus on estimating the average causal effect of a time-varying binary treatment on an end-of-study outcome, offering limited tools for characterizing marginal causal dose-response relationships under...

Controlled Hydrogen Delivery by Single‐Atom Ru Accelerates Electrocatalytic Ammonia Synthesis

ABSTRACT Electrocatalytic nitric oxide reduction to ammonia (NORR) offers a dual opportunity for NO remediation and decentralized NH 3 production, yet its efficiency is often limited by competing pathways and unclear structure–function relationships. Here we introduce a reactant‐...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Controlled Hydrogen Delivery by Single‐Atom Ru Accelerates Electrocatalytic Ammonia Synthesis

ABSTRACT Electrocatalytic nitric oxide reduction to ammonia (NORR) offers a dual opportunity for NO remediation and decentralized NH 3 production, yet its efficiency is often limited by competing pathways and unclear structure–function relationships. Here we introduce a reactant‐...

Rethinking Disability for Sustainable Rehabilitation and OT Development in Armenia

Date presented: April 24, 2026 Primary Author and Speaker: V. Armineh Babikian, babikian@therapistsforarmenia.org

Cutaneous Adverse Events Associated with Semaglutide, Liraglutide and Tirzepatide: A Systematic Review

Background/Objectives: Incretin-based therapies, including glucagon like peptide-1 receptor agonists (GLP-1 RAs) and glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RAs, are increasingly prescribed for obesity, leading to greater recognition of associated dermatological...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

Trends in Dispensing of Opioids and Benzodiazepines Among Older Adults Admitted for an Acute Hip Fracture Between 2008 and 2024 in Ontario, Canada

INTRODUCTION: Opioids and benzodiazepines (BZDs) are commonly prescribed for managing pain, anxiety, and sleep-related problems following a hip fracture. Both opioids and BZDs carry risks of persistent dependence, falls, and mortality with long-term use. Despite these risks, Cana...

Atomic Site-Specific Eigenstrain for Efficient Electrocatalysis

Abstract Strain engineering is a powerful approach to tailoring the performance of metal electrocatalysts. Despite substantial advancements in controlling the average surface strain and establishing its correlation with catalytic activity, the impact of strain at individual activ...

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Microparticles of hydrogels, also known as microgels, have garnered extensive attention due to their versatile properties and wide range of applications in different fields of science, technology, and medicine. Among the developed technologies to produce microgels, the precise co...

The Association Between Price and Household Purchasing of No-Alcohol Beer in Great Britain and Spain

Background: The ethanol in alcoholic beverages is toxic to human health. Reducing alcohol-related harm, a major public health priority, requires reductions in the amount of ethanol consumed. Alongside policies that increase alcohol prices and restrict availability, encouraging su...

Microplastics in stair-step moss and lake water on Baffin Island, Nunavut, reflect a local source component

Microplastics (MPs) are contaminants of emerging Arctic concern due to their adverse effects on ecosystems, yet lake water and shorelands on Baffin Island, Nunavut, remain understudied for contamination. To address this knowledge gap, we investigated microplastic pollution in mos...

Exploring Latent Profiles of Word-Reading and Reading Comprehension Skills Among English–French Bilingual Children in Grades 1 to 3

This study aimed to advance our understanding of the reading profiles of bilinguals who are struggling readers. To this end, 198 English–French bilinguals attending French immersion were followed from Grades 1 to 3. Latent profile and transition analyses were conducted with measu...

Data Mining Sheds Light on a Novel Family of Plant-Associated Negative-Sense RNA Viruses Linked to Lispiviruses

Large-scale mining of public transcriptomic datasets can reveal viral diversity that remains invisible to conventional virus-surveillance approaches, while increasingly powerful structure-prediction methods provide a complementary route to characterizing highly divergent viral pr...

Shear Stress Regulates C-type Natriuretic Peptide Gene Expression by Valvular Endothelial Cells in a Sex-Dependent Manner

Abstract Aortic valve disease initiates on the fibrosa (aorta-facing) side of the valve leaflets, whereas the ventricularis side is disease-protected. Spatially predictable disease correlates with side-specific hemodynamics and gene expression: fibrosa-side valvular endothelial c...

Designing Surprise Bags for Surplus Foods

Problem definition: Surplus-food marketplaces, such as Too Good To Go, enable retailers to monetize leftover inventory and reduce food waste by selling discounted “surprise bags.” Participating stores, however, face complex operational challenges. They must jointly set a reservat...

Development and Validation of a Tool to Measure Documented Health Care Encounter Time

Importance Time toxicity, defined as the time patients spend receiving cancer treatment and interacting with health care systems, is an emerging treatment-related burden. Existing studies typically quantify time toxicity using health care contact days, which may inadequately capt...

Organized communities as pre-existing infrastructures of care during the COVID-19 pandemic: A transnational dialogue

This article draws from a community-engaged study of how ordinary people's social justice mobilization during the COVID-19 pandemic in Brazil, Canada, Germany, and Peru placed demands on local and national governments for equitable social policies. It challenges celebratory narra...