University of Toronto

Differential Impact of Body Mass Index on Minimal Disease Activity Across Therapies in Psoriatic Arthritis

Objectives Overweight and obesity are associated with reduced odds of achieving minimal disease activity (MDA). Whether this effect is mediated by direct inflammation or psychosocial factors remains unclear. This study aimed to assess a) the influence of body mass index (BMI) on...

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons

ABSTRACT Stress triggers rapid and reversible shifts in vital physiological functions from homeostatic operation to emergency response. However, the neural mechanisms regulating such functional stress states remain poorly understood. Here we identify a novel recurrent inhibitory...

Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning

Abstract Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care. This survey examines recent progress in medical LLMs, focusing on reasoning applications and requirements. We present a dual-vie...

Acceptability of oral health care: a scoping review of reviews to inform framework development

Abstract Background Canada launched the Canadian Dental Care Plan (CDCP) in 2023 to improve access by reducing cost barriers. Data from September 2025 indicate that only about half of enrollees had accessed services, highlighting that addressing affordability alone may not be suf...