University of Toronto

Toward predictive prosthetic socket modeling: Preliminary linear regression models of transradial limb–socket geometry

Socket fit is essential for successful upper-limb prosthetic devices, yet current design workflows remain labor-intensive and dependent on clinician experience. Several digital and algorithmic approaches have been proposed to partially automate socket design, many of which rely o...

Adherence to cervical cancer follow-up screening and lesion recurrence in sub-Saharan Africa: a systematic review and meta-analysis

Timely follow-up after screening and treatment is essential for effective cervical cancer prevention. However, adherence remains markedly low across many low-resource settings, where missed follow-up and high recurrence rates undermine the effectiveness of screening programs. As...

Responsible use of large language models in digital health: an equity-first governance framework

Large language models (LLMs) are being rapidly deployed for digital health, yet their equity impacts remain poorly characterized. We present an equity-first audit framework anchored in the first nations mental wellness continuum framework (FNMWCF) and apply it to three open-sourc...

Variance and local log-concavity of Poisson–binomial laws

Let W be the number of successes in independent trials with unequal success probabilities, with probability mass function f and variance V ≥ 1, and let D be the first index at which f decreases. The normalized Turán deficit δ_k = 1 − f_{k−1}f_{k+1}/f_k², a measure of local log-co...

Variance and local log-concavity of Poisson–binomial laws

Let W be the number of successes in independent trials with unequal success probabilities, with probability mass function f and variance V ≥ 1, and let D be the first index at which f decreases. The normalized Turán deficit δ_k = 1 − f_{k−1}f_{k+1}/f_k², a measure of local log-co...

Calmodulin: The Essential Biological Regulator Self-Regulates Its Activity, Structure and Function

Calmodulin is an evolutionarily conserved critical controller protein found in animals, plants, fungi, and microbes. As the primary calcium sensor and effector in eukaryotes, calmodulin translates calcium signals into vital biological responses by binding to and regulating calmod...

Disparities in Heat-Related Injuries Among People Experiencing Homelessness

This cohort study examines whether people experiencing homelessness in Ontario, Canada, have higher rates of heat-related injury than people not experiencing homelessness.

Exclusive and Any Breastfeeding, Infant Formula Feeding, and Childhood Growth

OBJECTIVES: To understand the association between exclusive breastfeeding, any breastfeeding, and infant formula feeding and childhood growth. METHODS: A longitudinal cohort study was conducted among children from birth up to 10 years in Toronto, Canada. The primary exposure was...

From hope to health: improving sexual and reproductive health knowledge among adolescent orphan girls through the ‘HopeBox’ intervention in Bangladesh

Background: Orphaned adolescent girls face critical barriers to accessing accurate sexual and reproductive health (SRH) knowledge, which predisposes them to risky sexual behaviours and their consequences. We aimed to evaluate the effectiveness of the 'HopeBox' intervention in imp...

Right on time: evaluating accuracy and timing of burn-severity assessments to support post-fire management

Abstract Effective wildfire impact assessment and post-fire management rely on burn-severity maps that accurately characterize fire effects on vegetation and soils. These maps inform time-sensitive activities such as post-fire flood and debris-flow modeling, risk mitigation for h...

An analysis of spatial mismatch and coordination mechanisms in river-sea systems

China's port system within the Yangtze River Economic Belt has evolved from a traditional coastal port–hinterland structure into a more interactive coastal–inland port network. Coastal ports such as Shanghai port now operate as interconnected nodes, where coordination and investm...

ReFun: Reconstructing Function Boundaries in EVM Bytecode

Recovering the structure of a Solidity smart contract from its deployed bytecode is a prerequisite for various downstream analyses, such as control-flow graph construction, decompilation, and clone detection. A central step in this task is identifying private functions. However,...

Do Coverage and Mutation Scores of LLM-Generated Test Suites Correlate with Their Effectiveness? (Replicability Study)

Recent advances in large language models (LLMs) have driven growing interest in using LLMs to automate test generation. Prior work commonly evaluates generated test suites using proxy metrics such as code coverage and mutation score. However, studies by Inozemtseva et al. and Pap...

The DESI Y1 RR Lyrae Catalog. I. Empirical Modeling of the Cyclic Variation of Spectroscopic Properties and a Chemodynamical Analysis of the Outer Halo

Abstract We present the catalog of RR Lyrae stars (RRLs) observed in the first year of operations of the Dark Energy Spectroscopic Instrument (DESI) survey. This catalog contains 6240 RRLs out to ∼120 kpc from the Galactic center and over 12,000 individual epochs with homogeneous...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Evaluating and Mitigating the Misguidance Effect of Buggy Code in LLM-Generated Unit Tests

While Large Language Models (LLMs) show great promise for automating unit test generation, recent studies suggest that the quality of generated tests can be negatively impacted when models are prompted with buggy code. This paper presents a new metric to quantitatively measure th...

Connectomic Determinants of Subcallosal Cingulate Deep Brain Stimulation for Depression

OBJECTIVE: Subcallosal cingulate (SCC) deep brain stimulation (DBS) has shown promise for treatment-resistant depression. This study retrospectively evaluated a large curated SCC-DBS dataset to identify connectomic factors associated with sustained clinical improvement across pat...

Generalized Nonlinear Bayesian Pulsar Timing with ENTERPRISE

Abstract We use the Bayesian methods in the ENTERPRISE package to examine the fully general parameterization of pulsar timing models in tandem with noise. We investigate four pulsars, PSRs J1600–3053, J2043+1711, J0740+6620, and J1640+2224, through the lens of Bayesian timing. We...

Acceptance of Organs From Deceased Donors: Results of a Global Survey.

Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We assessed knowledge and com...

The DESI Y1 RR Lyrae Catalog. II. The Metallicity Dependency of Pulsational Properties, the Shape of the RR Lyrae Instability Strip, and Metal Rich RR Lyrae

Abstract RR Lyrae stars (RRLs) are valuable probes of both Milky Way assembly and stellar-evolution physics. Using a sample 6240 RRLs obtained in the first year of the Dark Energy Spectroscopic Instrument (DESI) survey, we investigate the metallicity of RRLs and its correlation w...