University of Toronto

A Novel Approach to Characterizing Patterns of Real-World Upper-Extremity Use During Walking and Activities of Daily Living in People with Subacute Stroke

In accelerometer-based measurement, the inclusion of upper extremity (UE) activity during walking can overestimate real-world functional UE use in people post-stroke. This study introduces a comprehensive, accelerometer-based approach to examining real-world UE use, including the...

Mapping pediatric cardiac troponin testing worldwide: results from the IFCC survey on emerging applications, standardization needs and access

OBJECTIVES: Limited guidance on the use and interpretation of cardiac troponin (cTn) testing in pediatric populations has restricted its broader adoption, despite the significant burden of congenital and acquired cardiac conditions in children. This survey aimed to evaluate globa...

Janus kinase inhibitors combined with 308‐nm excimer laser for vitiligo: A systematic review

The data that supports the findings of this study are available in the external repository (https://data.mendeley.com/datasets/6rh8dcvmfv/1) of this article.

The dynamic and heterogeneous structure of the non-canonical inflammasome

Inflammasomes are high-molecular-weight complexes that play integral roles in the innate immune system, triggering an inflammatory cascade to protect against cellular stresses such as pathogenic bacteria. Both canonical and non-canonical inflammasomes have been described in the l...

The Risks to Patients Associated with Using Artificial Intelligence Tools in Pharmacy Practice: A Scoping Review

Artificial intelligence (AI) tools are being used in pharmacy practice in a variety of ways, such as enhancing the safety and efficiency of dispensing, compounding medications and helping pharmacists identify drug–drug interactions. The further development and use of these innova...

Deterministic, rule-following trajectory generation system for waypoint flight

Abstract Advanced Air Mobility operations require flight guidance systems that exhibit predictable, deterministic behavior and remain compatible with established navigation standards. Many existing online trajectory generation methods rely on numerical optimization, or time-param...

Role of consolidative surgery after chemotherapy in recurrent/metastatic adrenal cortical cancer (ACC): Princess Margaret Cancer Centre experience

Recurrent/Metastatic (R/M) ACC is aggressive with few effective treatment options. The role of surgery after chemotherapy remains unclear. Moreover, prognostic factors in R/M ACC are not well defined. R/M ACC patients treated at Princess Margaret Cancer Centre (2002–2019) were re...

Harmonic reverse time migration

Abstract In subsurface regions containing gas or hydrocarbons, porous rocks, fluid-saturated zones, and fracture networks, seismic waves may propagate nonlinearly, resulting in harmonic generation, waveform distortion, and even the formation of shocks. To address these acoustic n...

Zooarchaeology of Houses and Middens: Investigating Patterns of Assemblage Composition at Early Inuit Sites Across the North American Arctic

ABSTRACT This study examines faunal assemblages from paired semisubterranean houses and middens at 10 Early Inuit sites spanning the North American Arctic (ca. 1200–1500 ce ) to evaluate whether local resource bases or other factors primarily structure zooarchaeological variabili...

Effects of surface fluxes on the moist potential vorticity distribution in the axisymmetric tropical cyclone boundary layer

Abstract This study investigates the structure and dynamics of simulated tropical cyclone boundary layers (TCBLs) using a moist potential vorticity () framework. in the boundary layer of tropical cyclones is related to the distribution of equivalent potential temperature () and a...

Confirming the Validity of the New EULAR/ACR Classification Criteria for Pediatric Chronic Nonbacterial Osteomyelitis

Objectives We aimed to investigate the performance characteristics of the new European Alliance of Associations for Rheumatology (EULAR) /American College of Rheumatology (ACR) classification criteria for pediatric CNO, in a distinct real-world clinical setting and compare it to...

Defining Difficult-to-Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late D2T-RA Phenotypes

Objectives Despite advances in treat-to-target strategies, a subset of rheumatoid arthritis (RA) patients remains refractory to therapy, described as difficult-to-treat RA (D2T-RA). The European Alliance of Associations for Rheumatology (EULAR) has proposed formal criteria for D2...

Icotrokinra (ICO), a Novel Targeted Oral Peptide, in Patients (Pts) with Psoriatic Disease: Exploratory Assessments from a Phase 2 Psoriasis (PsO) Study Informing a Phase 3 Clinical Program in Psoriatic Arthritis (PsA)

Objectives PsA affects ~20-30% of patients with PsO, causing articular inflammation and impaired quality of life. ICO, a novel targeted oral peptide that binds IL-23 receptor, showed greater clinical response rates vs placebo and a favorable safety profile in moderate-to-severe p...

Identification of Clinical and Radiologic Markers of Disease Presentation in Patients with Scleroderma Related Interstitial Lung Disease (SSc-ILD) in a Cohort from Ontario, Canada

Objectives Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy, inflammation and fibrosis of multiple organs including the skin, lungs, heart, and GI tract.[1] Lung involvement, characterized by interstitial lung disease (SSc-ILD) and pulmon...

Acyl-Alkyl-Phosphatidylcholine C40:6 is Potentially a Causal Biomarker for Obesity-Related Knee Osteoarthritis: Data from 4 Independent Cohorts

Objectives To identify potential causal biomarkers for obesity-related knee osteoarthritis (OB+OA+) by metabolome-wide association analysis (MWA) and Mendelian randomization (MR). Methods Four cohorts were included: the Newfoundland Osteoarthritis Study (NFOAS) as discovery, the...

The Ink Strikes Back: Tattoo-Associated Uveitis Syndrome. A 5-Case Series

Objectives Tattoo-Associated Uveitis Syndrome (TAUS) is a rare immune-mediated condition characterized by synchronous inflammation, including some cases with granulomatous involvement, of tattooed skin and ocular structures, reflecting a hypersensitivity to pigment antigens. This...

A Novel Approach to Monitoring Calcinosis in Juvenile Dermatomyositis: Serial Low-Dose Whole-Body CT

Objectives Evaluating the overall impact of calcinosis and response to therapy in juvenile dermatomyositis (JDM) remains challenging, primarily relying on physician assessments or plain X-rays.[1] We aimed to explore the use of an ultra-low-dose protocol for whole-body CT imaging...

Clinical Relevance of Pelvic and Heel Enthesophytes in Psoriatic Arthritis

Objectives Enthesitis is a hallmark feature of psoriatic arthritis (PsA), but its clinical assessment can be confounded by subjective assessment and overlapping fibromyalgia. We aimed to investigate the clinical and functional associations of radiographic enthesophytes in a large...

Sex Disparities in Clinical Need, Willingness, and Surgeon Recommendations for Total Knee Arthroplasty

Objectives Sex disparities exist in the receipt of total knee arthroplasty (TKA) for osteoarthritis (OA), with females disproportionately less likely to undergo surgery. Understanding the reasons for this gap is critical for equitable health care delivery. Lower willingness to un...

Team-Based Outpatient Rheumatology Care: A Scoping Review of Terminology, Team Composition, and Impact on Advancing the Quintuple Aim

Objectives Team-based models of rheumatology care, in which rheumatologists and interdisciplinary healthcare professionals (IHPs) collaborate in care delivery, are increasingly recognized to improve outcomes across all domains of the Quintuple Aim (population health, patient expe...