Institution
University of Toronto
Recent research
- Engineering & TechnologyOpen access
Shade-Aware Pedestrian Routing Without Online Shadow Generation: How Much Model Do We Actually Need?
Extreme heat is becoming a routine summer hazard, and the people most exposed are those who must walk: to transit, to work, to a cooling centre. Time in direct sun is the largest term a route can change in a pedestrian’s heat load, so shaded routing is an adaptation lever needing...
- Health & MedicineOpen access
Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...
- Health & MedicineOpen access
Preterm Risk Factors, Epigenetic Age, and Neurodevelopmental Outcomes
Importance Studies examining biological factors associated with neurodevelopment in the preterm population are limited. It was previously demonstrated that epigenetic age acceleration was associated with better neurodevelopmental outcomes among children born preterm. It is unclea...
- BiologyOpen access
The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index...
- AI & ComputingOpen access
Variable Selection for the Propensity Score Model: Beyond Main Effects and Linear Relations
ABSTRACT Propensity score methods are frequently used to estimate treatment effects in observational studies. The propensity score is usually estimated using a logistic regression model with additive and linear effects. The limited literature on variable selection for the propens...
- Health & MedicineOpen access
Abstract Background We conducted a systematic review of clinical trials and cohort studies on HIV post‐exposure prophylaxis (PEP) regimens to inform updated 2025 Canadian guidelines. Methods We searched Medline and Embase (July 2017–June 2024) for studies reporting on: HIV acquis...
- Health & MedicineOpen access
Abstract Background Ninety-nine percent of global maternity deaths occur in low-and-middle-income countries (LMICs), despite availability of high quality evidence-based guidelines for common causes of maternal mortality. An understanding of barriers and facilitators (BFs) to acce...
- Society & EconomicsOpen access
Sex trafficking is a pervasive health and human rights issue, disproportionately experienced by structurally marginalized women and girls, in Canada and globally. Specialized forensic nurses are well positioned to respond to sex trafficking by offering needed supports, however, c...
- Health & MedicineOpen access
Drug-induced parkinsonism is a potentially reversible movement disorder that may be subtle and difficult to monitor in residential dementia care. Vision-based machine learning analysis of gait may provide unobtrusive longitudinal monitoring around medication changes. We conducted...
- Physics & SpaceOpen access
OmniCosmos: Transferring Particle Physics Knowledge Across the Cosmos
Foundation models build an effective representation of data that can be deployed on diverse downstream tasks. Previous research showed that the , a foundation model for collider physics, could significantly advance discovery potential across collider experiments. In this paper, w...
- Health & MedicineOpen access
Objectives Social determinants of health (SDOH) and race are associated with disease activity, including lower achievement of the low lupus disease activity state (LLDAS), but it is unknown whether these factors are associated with patient-reported outcomes (PROs). Among a cohort...
- Health & MedicineOpen access
Ultraprocessed Food Intake and Adiposity, Vascular Brain Injury, and Cognition in Middle-Aged Adults
Importance Ultraprocessed foods (UPFs) account for a substantial and increasing proportion of dietary intake in Canada. Although UPFs are consistently associated with adiposity and cardiometabolic disease, their associations with subclinical vascular brain injury (VBI) and cognit...
- BiologyOpen access
Electrochemical peptide technologies usually place a substrate, mediator, enzyme, or protected growing chain in direct electrical communication with an electrode. This Perspective proposes a different architecture: paired-fraction electrochemical programming, in which anodic and...
- Health & MedicineOpen access
BACKGROUND: Female pattern hair loss (FPHL), characterized by progressive follicular miniaturization, is the most common cause of hair thinning in women and increases in prevalence after menopause. While topical minoxidil is approved for FPHL, clinical response is variable. Oral...
- BiologyOpen access
Arginine vasopressin (AVP) is a cyclic amidated nonapeptide containing a Cys1-Cys6 disulfide and a strongly basic Arg8 residue. This Perspective derives an AVP-specific implementation of paired-fraction electrochemical programming (PFEP). The divided electrochemical cell is treat...
- BiologyOpen access
Somatostatin-14 is a 14-residue cyclic peptide closed by a Cys3-Cys14 disulfide and containing an oxidation-sensitive Trp8 residue. This combination makes it a discriminating test of paired-fraction electrochemical programming (PFEP): a useful process must create the disulfide wi...
- Physics & SpaceOpen access
Cosmological Constraints from Full-scale Clustering and Galaxy–Galaxy Lensing with DESI DR1
Abstract We present constraints on cosmic structure growth from the analysis of galaxy clustering and galaxy–galaxy lensing with galaxies from the Dark Energy Spectroscopic Instrument (DESI) Data Release 1. Our analysis includes four samples drawn from the Bright Galaxy Survey (B...
- BiologyOpen access
PFEP Preconditioning of Exenatide Solutions: Separating Compounding History from Long-Term Stability
Exenatide is a 39-residue linear peptide whose solution degradation is strongly pH dependent. Published work shows relative stability near pH 4.5, oxidation-dominant loss at pH 5.5–6.5, and increasing deamidation and aggregation at pH 7.5–8.5. This article tests a bounded PFEP pr...
- BiologyOpen access
Electrochemical peptide technologies usually place a substrate, mediator, enzyme, or protected growing chain in direct electrical communication with an electrode. This Perspective proposes a different architecture: paired-fraction electrochemical programming, in which anodic and...
- Health & MedicineOpen access
Background Many Canadians experience prolonged pain, uncertainty, and stigma before receiving an endometriosis diagnosis, with delays averaging 11 years from symptom onset. Endometriosis, defined by the presence of endometrial-like tissue outside the uterine cavity, impacts 10% o...