University of Toronto

Identification, validation, and prediction of longitudinal recovery phenotypes in degenerative cervical myelopathy: analysis of prospective cohorts and a randomised controlled trial

Background Symptom evolution in degenerative cervical myelopathy (DCM) is traditionally characterized by severity of neurological deficit. A recent expert consensus challenged this view, proposing that DCM fluctuates across neurological, functional and health-related quality of l...

P1.014. Gastroesophageal Intussusception After Myotomy for Achalasia

Abstract Topic Benign Disease: Esophageal Function and Motility Case Submission Gastroesophageal intussusception (GEI) is a rare condition in adults, defined by telescoping of the stomach into the oesophagus. Its presentation is often nonspecific—manifesting as dysphagia, vomitin...

Programming of deep brain stimulation of the centromedian nucleus of the thalamus for drug‐resistant epilepsy: A meta‐analysis and proposed programming framework

Abstract Objective Although the centromedian nucleus of the thalamus (CM) is an increasingly considered deep brain stimulation (DBS) target for drug‐resistant epilepsy (DRE), there is significant variability in programming practices, which may contribute to heterogenous outcomes....

P1.141. A Machine Learning Model for Assessment of Conduit Perfusion in Robotic Assisted Minimally Invasive Esophagectomy Using Indocyanine Green

Abstract Topic Esophageal Cancer: Other Background Anastomotic leak remains a major complication in esophagectomy. Indocyanine Green (ICG) can assist with the assessment of conduit perfusion but remains subjective and prone to bias. Our lab has worked to design a computer vision...

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Assessing Challenges and Barriers to Effective Wound Care in Rural Indigenous Communities

OBJECTIVE: To explore the lived experiences of patients with chronic wounds from a remote Indigenous community in Northern Manitoba, Canada, focusing on challenges in wound management, the impact on quality of life, barriers to wound care access, and the role of traditional heali...

Revisiting the association between musical expertise and second-language proficiency

Abstract Musical expertise is frequently correlated with second-language (L2) proficiency, but it remains unclear whether this association generalizes across languages and measures. Here, we examined links between musical expertise and L2 proficiency among native speakers of Port...

“As soon as it’s trying to be persuasive, my skepticism kicks in”: A qualitative study to co-design vaccine communication strategies with vaccine hesitant adults in Canada

Vaccine hesitancy continues to impede vaccine uptake in Canada. Few interventions directly engage hesitant adults in co-designing communication materials. This study aimed to co-develop and evaluate digital vaccine communication messages with hesitant adults in Canada to improve...

Assortment Optimization for the Multinomial Logit Model with Repeated Customer Interactions

This paper presents the multinomial logit model with repeated customer interactions. In each period, the same customer selects a product from the recommended assortment or opts out. From the seller’s perspective, the choice probability in the current period is updated based on th...

ELSSA: Explainable large language model-based decision support for public transit incident management

Rapid incident response in public transit requires supervisors to make defensible decisions that align with both formal standard operating procedures (SOPs) and practical agency experience recorded in past reports. However, conventional retrieval-augmented generation (RAG) often...

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Proper Orthogonal Decomposition-based Model-Order Reduction for Smoothed Particle Hydrodynamics Simulation—Mass-Spring-Damper System

Model Order Reduction (MOR) based on Proper Orthogonal Decomposition (POD) and Smooth Particle Hydrodynamics (SPH) has proven effective in various applications. Most MOR methods utilizing POD are implemented within a pure Eulerian framework, while significantly less attention has...

Artificial intelligence-enabled analysis of electron micrographs to assess mitochondrial morphology in triple-negative breast cancer

Advancements in transmission electron microscopy (TEM) have enabled in-depth studies of biological specimens, offering new avenues to large-scale imaging experiments with subcellular resolution. Mitochondrial morphology is of growing interest in cancer biology due to its crucial...

Reasonable Exceptions From Unreasonable Policies: Requiring Treatment Agreements for Long‐Term Opioid Therapy and Exemptions for Cancer and Terminal Illness

Since drug overdose deaths began increasing in the United States, policy makers and the medical community have developed tools to try to address the crisis. Opioid Treatment Agreements (OTAs) are one such tool which purportedly seek to promote shared decision-making and informed...

More than 79.47% of the zeros of the Riemann zeta function are simple and on the critical line

This preprint presents a certified-candidate proof that, with ineffective constants, more than 79.47% of the nontrivial zeros of the Riemann zeta function are simple and lie on the critical line, and more than 89.73% lie on the critical line. Building on the "two-thirds theorem"...

Time-dependent analysis of HUS change in older patients aged > 75 years with head and neck cancer

Previous longitudinal evidence has suggested that patients aged > 75 years may be associated with a poorer Health Utility Index Mark 3 (HUI-3) trajectory. We compared the longitudinal health utility scores (HUS) of older (>75 years) versus younger patients with head and neck canc...

Operationalizing Patient Experience Data as a System Feedback Asset in Learning Health Systems: Learnings From Model of Care Redesign at Trillium Health Partners

ABSTRACT Introduction Learning Health Systems (LHS) offer a pathway to continuously improve care by integrating data and lived experience, yet few practical examples demonstrate how LHS can be operationalized in hospital settings in ways that embed the voices of patients and fami...

Neural dynamics underlying minute-timescale persistent behaviour in the human brain

Pursuing longer-term goals relies on representations of task context that can be maintained over long periods of time and switched flexibly when goals change. Little is known about the neural substrate for maintaining context representations on the minute-timescale on which human...

Entrustment–supervision progression across core entrustable professional activities in undergraduate nursing clinical rotations: a prospective longitudinal study

Entrustable professional activities (EPAs) operationalize competency-based education by linking assessment to observable clinical tasks and supervision decisions. Although EPAs are widely implemented in postgraduate and advanced nursing education, quantitative evidence describing...

Global inequitable distribution of seminal studies of chemotherapy-induced nausea and vomiting

BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) remains one of the most quality of life limiting toxicities of cancer therapy. Decades of trials have produced robust antiemetic evidence, but their applicability to resource-limited settings where guideline-recommended...