University of Copenhagen

Net carbon losses in Central African forests revealed by high-resolution biomass change maps

Dense humid forests in Central Africa hold vast biomass carbon stocks but are increasingly affected by small-scale disturbances that are difficult to detect with current satellite observations. Here, we generate 10 m canopy height maps for 2019–2022 using deep learning with space...

A Systematic Review (and Meta-Analysis) and Global Expert Consensus Statements (U-POP): The Manchester Procedure

Abstract Introduction and Hypothesis The Manchester procedure (MP) is the oldest uterus-sparing technique for uterine prolapse and has traditionally been used to treat cervical elongation (CE). However, its optimal application remains unclear. This review aimed to evaluate the be...

Redescription of the cranial morphology of Amphisbaena braestrupi and Amphisbaena laurenti (Squamata: Amphisbaenidae) from the Pleistocene of Brazil using x‐ray computed tomography

Abstract Amphisbaenians (Squamata: Amphisbaenidae) are fossorial reptiles with highly specialized cranial morphology, yet their fossil record is frequently limited by fragmentary preservation. This study provides a detailed osteological redescription of the skulls of Amphisbaena...

Transverse Myelitis and Guillain–Barré Syndrome in Pediatric Lymphoid Malignancies: An International Retrospective Study

Central and peripheral neurotoxicity after methotrexate is a rare but challenging complication of therapy for pediatric lymphoid malignancies. In this Ponte-di-Legno Toxicity Working Group and international Berlin-Frankfurt-Münster Group study, we describe nine children and adole...

Pattern of Failure in Nasopharyngeal Carcinoma After Radiotherapy in a Low‐Incidence Population: A DAHANCA Study

BACKGROUND: Nasopharyngeal carcinoma (NPC) is uncommon in many populations. Most existing clinical evidence comes from endemic areas, where Epstein-Barr virus (EBV)-associated subtypes predominate. We analyzed patterns of failure in a population-based cohort from Denmark, a low-i...

Sleep Duration and Metabolic Biomarkers During Pregnancy: A Longitudinal Study in a Multiracial Cohort

Abstract Objective: To examine associations between sleep duration and metabolic biomarkers in pregnant women. Methods: This nested case-control study involved 321 pregnant women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth...

Awake or Asleep Subthalamic Deep Brain Stimulation for Parkinson's Disease: Further Research Is Needed

BACKGROUND AND OBJECTIVES: This systematic review aims to evaluate the differences in clinical efficacy and quality of life between asleep and awake subthalamic nucleus deep brain stimulation (STN-DBS) procedures in patients with Parkinson's disease. METHODS: A comprehensive sear...

Structural and functional insights into a Zn2+-transporting P-type ATPase

Abstract Zinc is essential for life yet toxic in excess, rendering homeostatic control vital for all organisms. Transition metal transporting P-type (P IB -) ATPase proteins are critical for this balance but remain poorly understood at the molecular level. Here, we present the in...

Reduced BVOC emissions from birch forest understory during coupled insect outbreak and microclimatic forcing

Abstract Insect outbreaks are intensifying across high-latitude forests, yet their effects on biogenic volatile organic compound (BVOC) emissions from understory vegetation remain poorly resolved under natural outbreak conditions. Here, we examine how a severe geometrid moth outb...

Housing tenure, climate resilience, and ecological segregation

A key challenge to ensuring no one is left behind in the green transition lies in the persistent segregation of urban populations and the unequal distribution of environmental costs and benefits. Residential segregation has long reinforced socioeconomic and racialized disparities...

Practical Computational Exploration of Chemical Reaction Space: Assessing the Chemical Stability of Active Pharmaceutical Ingredients Under Acidic Conditions

ABSTRACT Understanding the chemical degradation of active pharmaceutical ingredients is critical for formulation development and regulatory compliance, yet computational tools either rely on predefined reaction rules that limit discovery of unanticipated pathways or cannot distin...

Longitudinal health-related quality of life after electrochemotherapy in elderly patients with cutaneous melanoma

The incidence of cutaneous melanoma (CM) is increasing among elderly patients, who often present with advanced disease, including cutaneous metastases. Electrochemotherapy (ECT) is a local ablative treatment that enhances chemotherapy uptake via electric pulses. Management in pat...

Precision ID mtDNA Whole Genome Panel and sequencing of telogen hairs – perspectives for validation and implementation in casework

Abstract Shed hair is a commonly encountered type of forensic evidence. Shed telogen hairs generally contain insufficient or highly degraded nuclear DNA for STR profiling; however, mtDNA analysis of telogen hair and hair shafts remains possible. We validated whole mitochondrial g...

Implication of Sulfatide in Type 1 Diabetes and Multiple Sclerosis. Comment on Root-Bernstein, R. Type 1 Diabetes-Associated Autoantibodies, Sera and T-Cell Receptor Sequences Recognize Myelin Basic Protein: A Novel Peripheral Diabetic Neuropathy–Multiple Sclerosis Connection. Cells 2026, 15, 1384

An interesting article by Root-Bernstein [...]

The parent bodies of Ryugu and Ivuna formed before those of other carbonaceous chondrites

Most carbonaceous chondrite (CC) meteorites contain abundant chondrules, millimeter-scale spherical inclusions of previously molten material. Ivuna-type carbonaceous chondrites (CIs) do not contain chondrules, nor do samples of the carbonaceous asteroid Ryugu. CIs and Ryugu share...

Intracerebral Glutamate and Glycerol in Severe Acute Brain Injury: Retrospective Study of Association With Neuroworsening and Outcome

ABSTRACT Background Glutamate is the main excitatory neurotransmitter in the brain, and extracellular levels of glutamate and glycerol (a breakdown product of cell damage) increase after severe acute brain injury. Previous studies report that increased intracerebral glutamate—mea...

On destructive memories and the role of language in living with one’s past

Abstract In the context of memory, the present paper investigates the consequences of undergoing a change concerning one’s ethical outlook. First, we motivate the idea that we can become alienated from our own memories by revisiting Bernard Williams’ idea of Relativism of distanc...

Ancient DNA preservation in the Caribbean

Abstract Ancient DNA (aDNA) analysis has transformed how we study human migration, species dispersals and environmental change, but poor preservation remains a major challenge. This is especially true in tropical settings, where hot and humid conditions accelerate DNA decay. Beca...

Early‐stage myocardial changes are not aggravated by Western diet or ageing in Mybpc3 c.2373insG heterozygous mice

Abstract Hypertrophic cardiomyopathy (HCM) caused by heterozygous pathogenic gene variants is characterized by highly variable disease phenotypes. Ageing and systemic metabolic disruption are thought to act as additional ‘second hits’ that modulate this genotype–phenotype relatio...

Loss of galactan synthesis in pea (Pisum sativum) causes defects in organ expansion and is associated with increased extensin content

Abstract Pectic galactan is a rhamnogalacturonan-I side chain, composed of β-(1→4)-linked D-galactose residues. Its multifunctional role in cell wall assembly and properties has been proposed in various developmental contexts. In this study, we investigated the role of galactan i...