University of Copenhagen

Histone H1 boosts chemokine signaling and immune cell migration in a charge-dependent manner

Histones are released by neutrophils at sites of inflammation where they help immobilize and kill invading pathogens. However, the broader role of histones in pathogen protection remains elusive. In vitro cell signaling and 3D chemotaxis assays using human cell lines and primary...

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal...

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease

Alzheimer’s disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on populatio...

Single-nucleus transcriptome-wide association study of human brain disorders

Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many...

‘I feel like a pinball’: patient experiences with a coordinated treatment model in dual diagnosis

To examine dual diagnosis patients’ experiences with cross-sectoral interventions in SPOR, a coordinated treatment model between municipal substance use centres and regional outpatient psychiatry in the Capital Region of Denmark. Eight semi-structured interviews were conducted wi...

Childhood body mass index trajectories and subtypes of endometrial cancer: A Danish cohort study

Background Obesity in adulthood is a well-established risk factor for endometrial cancer, a heterogeneous disease comprising several histological subtypes. Although childhood body mass index (BMI) is linked to endometrial cancer, the role of childhood growth patterns in different...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

Association of major depression with return to work and changes in employment rate across sociodemographic municipality characteristics: A register-based cohort study

AIMS: We examined whether the association between depression and return to work (RTW) varied by municipality characteristics. METHODS: In this nationwide register-based cohort study (2012-2018), adults aged 25-55 years with a first-time in- or outpatient contact for depression we...

Structural and Spin–Orbit Coupling Synergy Enables Tunable Afterglow in Cytosine‐Based Hybrid Materials

ABSTRACT Developing room‐temperature phosphorescent (RTP) materials with time‐dependent optical responses is of great interest for advanced information security applications. Herein, zinc‐based organic–inorganic metal halides, (Cyt) 2 ZnX 4 ·H 2 O (X = Cl, Br), were synthesized u...

Feeling ill, not harmed: a phenomenological account of the long-term experience of false-positive breast cancer screening

Scholarship has highlighted how the identification of breast cancer risk and false-positive screening results operate as modes of governance that shape subjects and extend the reach of medicine. Building upon this work, this article offers a phenomenologically-informed analysis o...

Household consumer purchases and chronic disease

Chronic disease risk stratification remains costly and often provides limited insight into modifiable exposures. Consumer purchases are routinely generated, low-burden measures of household lifestyle that can be linked to health outcomes with consent. In this Danish cohort study,...

Long-term patient-reported outcomes following initial non-operative management of uncomplicated gallstone disease

Abstract Background Conservative management is commonly used for selected patients with symptomatic, uncomplicated gallstone disease and mild symptoms. However, long-term patient-reported outcomes after an initial non-operative strategy remain poorly described. This study aimed t...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

Assisted cycling in non-ambulant adults with cerebral palsy: exploratory effects and feasibility in residential care

OBJECTIVE: Adults with cerebral palsy (Gross Motor Function Classification System, GMFCS, levels III-V) have severely impaired motor function, causing fatigue, pain, constipation, and sleep disturbance, reducing life quality. Whether standard exercise is feasible or beneficial in...

Exploring L-tyrosine and L-DOPA biosynthesis in faba bean ( Vicia faba L.)

BACKGROUND AND AIMS: L-DOPA is an important pharmaceutical that accumulates to high levels in the legume faba bean (Vicia faba). L-DOPA is likely derived from L-tyrosine but the responsible enzyme (L-tyrosine oxidase) remains unknown. Availability of L-tyrosine may be a key facto...

Towards molecular-based functional classification of fetal bovine serum

Quality and price of fetal bovine serum (FBS) are traditionally determined by geographical origin and parameters listed in the Certificate of Analysis (CoA). Despite its central role in cell culture, selecting suitable FBS batches remains costly and labor-intensive due to substan...

Nonparametric Survival Estimation With Contaminated and Adjudicated Events

ABSTRACT We study the conditional expert Kaplan–Meier estimator, an extension of the classical Kaplan–Meier estimator designed for time‐to‐event data subject to both right‐censoring and contamination. Such contamination, where observed events may not reflect true outcomes, is com...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower‐risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo‐controlled trial

BACKGROUND: Vitamin C (VitC) is a cofactor for TET enzymes involved in DNA demethylation and epigenetic regulation. Mutations in TET2 are common drivers of leukemia. Preclinical studies suggest that VitC may delay leukemia progression. This study aimed to evaluate the biological...

Scalable clinical proteomics from DNA/RNA extraction flowthroughs enables integrated proteogenomic profiling from a single cancer biopsy

Abstract Background Precision oncology has largely relied on genomic and transcriptomic sequencing to guide therapy selection in patients with advanced cancer. However, these molecular layers do not fully capture the functional state of tumors, as proteins largely represent the a...