University of Copenhagen

eDNA-based assessment of microbial dynamics in response to persistent contaminants and degraded water quality in a hypereutrophic urban reservoir

Abstract Urban freshwater ecosystems are increasingly exposed to mixtures of pollutants, including per- and polyfluoroalkyl substances (PFAS). However, their ecological effects remain poorly understood, especially in tropical regions with limited sanitation infrastructure. This s...

Poisoning With Toxic Alcohols in Denmark

INTRODUCTION: Poisoning with ethylene glycol and methanol remains a recurrent problem in Scandinavia. This study aimed to describe the epidemiology, exposure circumstances, clinical characteristics and management of toxic alcohol poisonings reported to the Danish Poison Informati...

P1.158. Clinical Performance of a Liquid Fiducial Marker for Preoperative Marking of the Optimal Resection Line in Gastroesophageal Cancer Surgery

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophageal and gastroesophageal junction cancers have a poor prognosis despite improvements in curative treatment. Achieving microscopically cancer-free resection margins is essential for long-te...

OA03-RF01.05. The Safety and Efficacy of Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma in Scandinavia (SEES-Study)

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Endoscopic submucosal dissection (ESD) is recommended for early-stage esophageal squamous cell carcinoma (ESCC). Most data on the efficacy of ESD for ESCC comes...

Internet-based Emotion Regulation Individual Therapy for Adolescents (IERITA) plus treatment as usual versus treatment as usual for adolescent outpatients with non-suicidal self-injury—the TEENS multi-site trial: study protocol and statistical analysis plan for a multi-site randomised clinical trial

Non-suicidal self-injury (NSSI) is a public health concern and a widespread behaviour, especially among adolescents. NSSI is an indicator of psychological distress and a known risk factor for later suicidal behaviour and death by suicide; however, evidence-based treatment options...

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Viral commitment to infection depends on host metabolism

Viral infection begins with attachment to host surface structures such as receptors, pili, or porins. While prior research has focused on structural compatibility and recognition, the role of host physiology, particularly metabolic state, on viral commitment to infection remains...

Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide

PURPOSE: It is often reported that people with schizophrenia experience weight gain and disordered eating, partly due to antipsychotics. As part of the RCT "Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes, HISTORI", the present study investig...

Tracking funding disparities in global health aid with machine learning

Abstract Reducing the global burden of disease is crucial for improving health outcomes. However, misalignment between health aid and country-level disease burden leaves vulnerable populations without the necessary support for major health challenges, particularly in the least de...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Unlocking Scalable Ligand Residence Time Predictions with Koffee Unbinding Kinetics Simulations

A great number of drug discovery programs fail due to poor in vivo efficacy and ADMET liabilities. On- and off-target ligand residence times can act as important drivers of these problems. While modern experimental techniques have made measuring compound kinetics data more routin...

Circulating biomarkers reflecting type III, IV and VI collagen remodeling are present in lung tissue of patients with pulmonary fibrosis and non-fibrotic controls

Abstract Background The extracellular matrix (ECM) is a dynamic network that provides structural support and maintains tissue homeostasis. Collagens are the main structural components of the ECM, occupying distinct tissue compartments and serving specialized roles. Dysregulated E...

The Star Formation History and Evolution of the Ultra-Diffuse M81 Satellite F8D1

Abstract We present deep Hubble Space Telescope (HST) imaging of one of the nearest ultra-diffuse galaxies (UDGs) outside of the Local Group: F8D1, a satellite of M81 known to be tidally disrupting. UDGs are an enigmatic and diverse population, with evolutionary pathways ranging...

Prognostic Impact of Kidney Function before Transcatheter Aortic Valve Implantation - A Nationwide study

Abstract Background Prognosis after transcatheter aortic valve implantation (TAVI) keeps improving, yet some high-risk groups persist with chronic kidney disease being one. Contemporary data on the prognostic importance of pre-TAVI kidney function are sparse, leaving uncertainty...

When indemnity insurance fails: Parametric coverage under binding budget and risk constraints

Abstract In high‐risk environments, traditional indemnity insurance is often unaffordable or ineffective, despite its well‐known optimality under expected utility. We compare excess‐of‐loss indemnity insurance with parametric insurance within a common mean‐variance framework, all...

Contrast-free super-resolution ultrasound imaging for microvascular assessment of murine subcutaneous tumour models in preclinical oncology

<title>Abstract</title> <bold>Introduction</bold> . Tumour vascularity is an important biomarker of tumour growth and therapeutic response. Current in vivo imaging methods have a limited ability to detect individual tumour vessels due to the small vessel size and low flow rates c...

Advancing phosphorus foliar fertilization with nano-hydroxyapatite: mechanisms and agricultural relevance

<title>Abstract</title> Phosphorus (P) use in agriculture remains inefficient and poses long-term environmental concerns. We investigate the uptake, redistribution, and efficacy of foliar-applied nano-hydroxyapatite (nHAp) in P-deficient barley (Hordeum vulgare), aiming to clarif...

New insights into the evolution of Charlie Chaplin worms (Histriobdellidae, Eunicida, Annelida)

Abstract Histriobdellidae, the so-called Charlie Chaplin worms, is an enigmatic group of microscopic commensal annelids associated with crustaceans. They crawl by alternately attaching their adhesive anterior appendages and left and right huge lateral ‘feet’, and bear a complex j...

The field divided: Team Melli and transnational Iranian politics

This study looks at how diasporic opponents of the Islamic Republic contested Team Melli’s status as a symbol of national unity during the 2022 World Cup, turning support for and opposition to the national team into an arena of contentious politics and activism. Using digital eth...

Positive equilibria in mass action networks: geometry and bounds

Abstract Any mass action network gives rise to a parameterised family of polynomial equations whose positive solutions are the positive equilibria of the network. Here, we consider alternative systems of equations, whose solutions are in smooth, one-to-one correspondence with pos...