Institution
University of Copenhagen
Recent research
- Health & MedicineOpen access
ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicl...
- Health & Medicine
Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis
BACKGROUND: In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clinical response-tailored antibiotic management strategy can shorten treat...
- BiologyOpen access
Purpose: Antimicrobial resistance (AMR) is making urinary tract infections (UTIs) and surgical site infections (SSIs) increasingly difficult to treat, especially in low-resource settings where self-medication and limited laboratory services are common. This study explored knowled...
- Health & MedicineOpen access
Background: Iodine is an essential micronutrient required for foetal development, cognitive function, and metabolic regulation; however, suboptimal iodine status remains a public health concern in Europe and other regions. Improving food literacy related to iodine may support hea...
- Health & MedicineOpen access
Background/Aim: Long-term management of systemic lupus erythematosus (SLE) requires a persistent balance between intensive immunosuppression and the prevention of opportunistic infections. This is particularly challenging in patients with a multi-decade disease history and evolvi...
- Health & MedicineOpen access
Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...
- AI & Computing
Introduction to AI Virtual Special Issue
Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
- Health & MedicineOpen access
Ketogenic interventions have garnered attention for their potential benefits in individuals with psychiatric and neurocognitive disorders. This review analyzed findings from studies investigating the impact of ketogenic interventions on clinical outcomes in individuals with serio...
- Health & MedicineOpen access
Patient-reported outcomes are insufficiently studied across the three predominant vascular diseases: lower extremity artery disease (LEAD), symptomatic carotid stenosis (SCS) and abdominal aortic aneurysm (AAA). To address this gap, the Danish Vascular (DanVasc) survey was develo...
- BiologyOpen access
Calibration improves estimation of linkage disequilibrium on low sample sizes
Linkage disequilibrium is a central statistic in population genetic studies, commonly measured by the squared correlation between pairs of genetic variants. An important drawback of this measure is its upward bias caused by a finite sample size. To handle this, different methods...
- BiologyOpen access
Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health
Abstract Metabolic interactions govern gut microbiome assembly, yet functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft genomes introduce system...
- BiologyOpen access
Carbon substrate type shapes spatial self-organization in a multi-species biofilm community
Abstract Spatial organization is a defining feature of multispecies biofilms and critically influences microbial interactions and emergent community properties. However, understanding and manipulating how microbes assemble into spatially structured biofilms remains challenging be...
- Physics & SpaceOpen access
Null fluid/gravity correspondence
A bstract We construct a new class of perturbative asymptotically Anti-de Sitter pp-wave spacetimes by performing a long-wavelength expansion of Kaigorodov metrics in arbitrary spacetime dimensions. Holographically, these spacetimes are described by a null fluid hydrodynamic expa...
- BiologyOpen access
Uncovering dynamic human brain phase coherence networks
Abstract Complex cognitive functions rely on coordinated communication between distributed brain regions, yet capturing these interactions as they evolve over time remains challenging. Traditional analyses of functional brain connectivity largely rely on correlations in signal am...
- BiologyOpen access
lncRNAs contribute to caste differentiation as a regulatory layer in ants
Abstract Caste differentiation in ants represents one of the major evolutionary transitions and provides a unique model for studying developmental mechanisms underlying division of labor. Genetically identical individuals follow divergent epigenetically-regulated developmental tr...
- Physics & SpaceOpen access
Potential sublimating exocomets around the young star PDS 70
Abstract Recent observations by the James Webb Space Telescope (JWST) have indicated the presence of water in the inner regions of the disc around the young protostar PDS 70, but the origin of this water remains unclear. Here we report the discovery of variable absorption lines o...
- BiologyOpen access
Abstract Background Opioids are considered ideal for managing moderate to severe post-operative pain in laboratory rodents, with buprenorphine being one of the most commonly used analgesics in rats. A long-acting buprenorphine formulation would be highly beneficial to avoid frequ...
- BiologyOpen access
Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering
Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...
- Health & MedicineOpen access
Error replication as an instructional strategy in simulation‐based procedural learning
Abstract Background Errors are an inevitable part of clinical learning, yet procedural training commonly emphasises error avoidance. This study examined the effect of deliberate replication of predefined procedural errors (Error Replication; ER), compared with error avoidance tra...
- Health & Medicine
ABSTRACT Systemic chronic inflammation contributes to the development of many age‐related chronic diseases and represents a promising target for interventions aiming at promoting healthy aging. Fisetin is a naturally occurring flavonoid with anti‐inflammatory, antioxidant and sen...