University of Copenhagen

Volatile depletion in rocky planets as a chemical fingerprint of hybrid accretion

Volatile depletion in rocky planets records their formation history. Earth and Mars grew through different hybrid pathways of pebble and planetesimal accretion, providing a new way to interpret the diversity of rocky planets beyond the Solar System.

Extensions: an urban placemaking tool

This paper highlights extensions as a form of people-led placemaking in resettlement sites of the urban peripheries' of Chennai, India. Drawing on in-depth qualitative fieldwork, the study traces habitability and disaster recovery processes of displaced communities by analysing t...

Long-term Mortality and Shock-rate in Patients Surviving Out-of-Hospital Cardiac Arrest with and without early implantation of an Implantable Cardioverter Defibrillator

Introduction In patients who survive out-of-hospital cardiac arrest (OHCA), guidelines for implantation of an implantable cardioverter-defibrillator (ICD) are not unequivocal.Methods Patients resuscitated from OHCA of cardiac cause, without a reversible cause and an expected surv...

Advanced Pulmonary Drug Delivery Systems: A Narrative Review

Pulmonary drug delivery systems have gained increasing attention as an effective strategy for the treatment of both respiratory and systemic diseases by enabling targeted, noninvasive, and efficient drug administration through the lungs, with advantages including rapid onset of a...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

The effect of high-frequency light flicker on pattern-reversal and steady-state visual evoked potentials in healthy subjects

Abstract Purpose We investigated the effect of screen technology on visual evoked potentials (VEPs) by comparing a standard Cathode Ray Tube (CRT) screen with two Liquid Crystal Display (LCD) Light-Emitting Diode (LED) screens with differing levels of latency and high-frequency b...

Vocal encoding of heritable sociability prevails over emotions in sheep bleats

Vocalizations of animals are good indicators of their emotions. Temperament is known to influence the regulation and expression of emotions. However, how animal temperament affects their vocalizations and particularly their vocal expressions of emotions remains largely unexplored...

Painted Teotihuacan glyphs of Cave 19, Chalcatzingo, Morelos, Mexico

The Mexican archaeological site of Chalcatzingo is best known as a Formative centre, famed for its extensive Olmec-style iconography ( c . 900–500 BC). Yet, recent investigations at Cave 19 on the western face of Cerro Delgado provide evidence of continued ritual use into the fou...

Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024

ABSTRACT Background Biologic drugs have substantially expanded treatment options for inflammatory bowel disease (IBD), but infection risk during exposure remains a concern. Aims To investigate the association between current use of tumour necrosis factor‐α inhibitors (TNFi), vedo...

Variation in assessment of dissection plane after transanal total mesorectal excision (TaTME) among experienced colorectal pathologists

Abstract Purpose Evaluation of the dissection plane is an important measure of surgical quality in relation to rectal cancer. Although well-defined criteria exist assessments may vary. The aim of this study was to assess variation in the evaluation of dissection plane of transana...

Single-cell atlas of transcriptomic vulnerability across brain disorders

Abstract Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited 1,2 . Here, to gain deeper insights into the aetiolo...

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal...

Transposable elements as evolutionary catalysts of ant macrodiversity

Transposable elements (TEs) are key contributors to genome evolution, yet their macroevolutionary roles in adaptive radiations remain poorly understood, as high-quality genomic resources at sufficient phylogenetic breadth and appropriate comparative methods have been lacking. Her...

The association of home characteristics and risk of respiratory tract infections and acute otitis media in the first 18 months of life: a study of ~ 48 000 children in the Danish National Birth Cohort

Respiratory tract infections (RTIs) and acute otitis media (AOM) in the first 18 months of life have a large societal and individual impact and household conditions may be important in primary prevention thereof. To assess protective and harmful prenatal home exposures on RTIs an...

Single-nucleus atlas of cell-type specific genetic regulation in the human brain

Abstract Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics, the cellular specificity of th...

Use of Ibuprofen Before and in Early Pregnancy Among Women With and Without Chronic Medical Diseases. A Cross‐Sectional Study

PURPOSE: While having a chronic medical disease (CMD) increases use of analgesics and anti-inflammatory drugs, sufficient knowledge regarding patterns of use during pregnancy is lacking. We aimed to describe ibuprofen use before and in early pregnancy among women with and without...

Histone H1 boosts chemokine signaling and immune cell migration in a charge-dependent manner

Histones are released by neutrophils at sites of inflammation where they help immobilize and kill invading pathogens. However, the broader role of histones in pathogen protection remains elusive. In vitro cell signaling and 3D chemotaxis assays using human cell lines and primary...

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease

Alzheimer’s disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on populatio...

Single-nucleus transcriptome-wide association study of human brain disorders

Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many...

‘I feel like a pinball’: patient experiences with a coordinated treatment model in dual diagnosis

To examine dual diagnosis patients’ experiences with cross-sectoral interventions in SPOR, a coordinated treatment model between municipal substance use centres and regional outpatient psychiatry in the Capital Region of Denmark. Eight semi-structured interviews were conducted wi...