University of Copenhagen

Phenotypic manifestations and variant reclassification of germline PTEN variants: a nationwide Danish study

Background Classification of heterozygous germline PTEN variants in patients with, or suspected of having, PTEN hamartoma tumour syndrome (PHTS) remains challenging. Accurate classification is essential as these patients require lifelong cancer surveillance. Methods We identified...

Stroke rate detection from accelerometer data on marine mammals

Overall dynamic body acceleration (ODBA) is widely used as a proxy for movement activity. However, for large, slow-moving animals such as cetaceans, ODBA is dominated by orientational shifts rather than dynamic movements. We argue for using stroke rate frequency as an alternative...

Can ICD‐11 Personality Disorder Trait Dimensions Be Categorically Specified?

ABSTRACT The new ICD‐11 Personality Disorder (PD) classification introduces a global severity classification (i.e., mild, moderate, and severe) of personality dysfunction, which may be further accompanied by up to five trait domain specifiers delineating individual manifestations...

Digital Game-Based Learning in Primary Education: A Cluster-Randomized Controlled Trial on Knowledge, Skills, and Motivation

Abstract Digital technologies are increasingly integrated into primary education, yet evidence remains limited regarding how digital game-based learning (DGBL) affects the relationships among musical knowledge acquisition, aural skills development, and classroom motivation. To ad...

Copenhagen longitudinal study on quality of life in a young adult population with gliomas

Abstract Background Patients diagnosed with glioma in the brain are prone to lowered quality of life (QoL). The risk of neurological symptoms and emotional burden may restrict participation in everyday life.The glioma diagnosis is considered chronic with a limited overall surviva...

Integrating life cycle thinking into EU law on end‐of‐life vehicles

Abstract The European Union (EU) framework for end‐of‐life vehicles (ELVs) has progressed beyond waste disposal to formally cover vehicle design, producer responsibility and material recovery. However, it is less clear whether these provisions effectively connect across the relev...

Association between p-tau181 in cerebrospinal fluid and shunt response in patients with normal-pressure hydrocephalus

Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is a treatable condition, but predicting shunt response remains challenging. Cerebrospinal fluid (CSF) biomarkers, including phosphorylated tau (p-tau181), have been suggested as potential predictors, although ex...

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

Penile cancer is a severe disease, and a large proportion is related to high-risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population-based data on the prevalence of p16 in penile cancer is scarce. We investigat...

Research on the ecology of the carnivorous sponge-associated iridovirus (CaSpA-IV) reveals its presence in the Cnidaria

Carnivorous sponge–associated iridovirus (CaSpA-IV) is a recently described virus identified in two deep-sea cladorhizid sponge species from the Gulf of Maine and Baffin Bay. To assess its ecological distribution and potential transmission pathways, we molecularly screened for Ca...

Biologic-assisted house dust mite immunotherapy in allergic asthma: could it provide a bridge toward de-escalation?

To the Editor,We read with great interest the three-year randomized study by Bozek and colleagues comparing omalizumab, subcutaneous house dust mite allergen immunotherapy (HDM-SCIT), their combina...

Risk of bone metastases on [18F]NaF PET/CT in 734 patients with newly diagnosed prostate cancer

Abstract Purpose International guidelines recommend assessment for bone metastases in patients with high-risk prostate cancer (PC) and those with unfavourable intermediate-risk disease. These recommendations are largely based on studies using planar bone scintigraphy. We aimed to...

Elevated remnant cholesterol is estimated to mediate part of excess cardiovascular risk in the metabolic syndrome: two cohort studies of 537,885 individuals

Abstract Background Individuals with the metabolic syndrome have elevated remnant cholesterol and increased cardiovascular risk. We tested the hypothesis that elevated remnant cholesterol mediates part of the excess risk of myocardial infarction, atherosclerotic cardiovascular di...

Virus-like particle display of the SARS-CoV-2 receptor-binding domain using a modular tag/catcher system enhances immunogenicity of a DNA vaccine in mice

The COVID-19 pandemic highlighted the critical need for adaptable, rapid-response vaccine platforms. While mRNA vaccines enabled fast and scalable development, their stringent cold-chain requirements limited global accessibility. DNA vaccines offer a similarly fast and flexible v...

Resistance of Icelandic lake ecosystems to two centuries of agricultural pressures despite growing instability

Abstract In the early nineteenth century, Iceland entered the global market, which caused a large expansion and modernisation of agricultural practices, including rising livestock numbers, higher crop density and the introduction of artificial fertilizers and pesticides. However,...

Revealing Subject-Specific Temporal Patterns from Longitudinal Data

MOTIVATION: Temporal multivariate data is ubiquitous in many domains, for instance, being collected over time at planned visits (every few months/years) in longitudinal cohorts, or every few minutes/hours in challenge tests. The analysis of such data often focuses on revealing th...

Perioperative Use of Vasoactive Agents in Patients Undergoing Gastrointestinal Surgery: A Protocol for a Scoping Review

BACKGROUND: Perioperative hypotension in patients undergoing gastrointestinal surgery is a known and well-described condition. Timely treatment of perioperative hypotension, regardless of the reason, is important in order to reduce the associated postoperative complications. The...

Phototrophicity and genomic composition in plant-associated Sphingomonas faeni strains

Abstract Solar radiation impacts most life forms on Earth as an energy source or a regulatory signal. Still, relatively little is known about phototrophic potential and strategies of environmental bacteria beyond cyanobacteria. This study explores the phototrophy related genomic...

Severe Odontogenic Infections With Endodontic Origin: A Retrospective Cohort Study

AIM: Endodontic infections can spread, leading to life-threatening systemic infections. However, the available literature is limited concerning factors associated with a higher risk. This study aimed to characterize patients hospitalized with a severe endodontic infection spread...

A Novel Tool to Create Digital Twin Temporal Bone Models for Virtual and 3D-Printing: Proof-of-Concept and Evaluation

Objective: To develop a haptic software tool for creating digital twin models for virtual or physical interaction based on cone beam (CB) computed tomography (CT) temporal bone imaging and to evaluate the quality of resulting 3D-printed models. Background: Temporal bone surgery i...

Ancient DNA reveals early use of melons in China’s Song dynasty

Abstract Melon ( Cucumis melo L.) domestication is thought to have occurred independently once in Northeast Africa and twice in India, but archaeobotanical seed remains point to a possible additional domestication in China. Because Cucumis seeds are difficult to diagnose morpholo...