University of Copenhagen

Low‐level light therapy for dry eye disease and meibomian gland dysfunction: A systematic review and meta‐analysis

Abstract A healthy tear film is vital for ocular surface integrity and relies on the coordinated function of the lacrimal glands, meibomian glands and conjunctival goblet cells. Dysfunction in any of these elements can lead to dry eye disease (DED). This systematic review and met...

Chronic alanine aminotransferase elevation in people with HIV : Time trends over 22 years and genetic predisposition

Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was d...

An ‘Empty’ [Fe 16 ] Cage and its Transformation into [Fe 17 ] and [Fe 30 ]

ABSTRACT Polymetallic clusters of Fe III constructed without organic bridging ligands are an emerging class of molecules with structures akin to iron oxide minerals, possessing large spin ground states and/or displaying spin frustration effects. All previous examples, [Fe 8 ], [F...

Taking a clinical history in adolescents and adults presenting with seizures or epilepsy

Abstract Despite advances in EEG, neuroimaging, and other diagnostic technologies, a carefully obtained clinical history remains the cornerstone of diagnosis, classification, and treatment planning. However, structured guidance on history‐taking that integrates state‐of‐the‐art e...

Synthetic capital: Fossil entanglements and the promise of overcoming scarcity

The future of fossil capital is dictated not only by electrification but also by its relationship to what we refer to as ‘synthetic capital’. Synthetic capital captures the use of hydrocarbons as the material basis for the production and circulation of synthetics in all their var...

The future management of HS : People with HS as partners

Abstract Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease with profound impact on quality of life. Increasing recognition of the patient's role as an active partner in their own care has transformed approaches to disease management, yet a conceptual framework...

The novel HUGS colon model enables high-throughput parallel cultivation of metabolically active human gut microbiomes in vitro

Abstract In vitro models simulating the human gut are useful tools for understanding the complexity of the gastrointestinal microbiome and its interactions with food components and other environmental factors. However, existing colon models are either relatively simple, leaving i...

Persistent Health Disparities Among Adult Cancer Survivors

ABSTRACT Cancer survivors face elevated risks of age‐ and treatment‐related health conditions, possibly due to accelerated biological aging from cancer therapy. The role of social determinants of health (SDOH) in these aging trajectories remains understudied. We conducted a retro...

The genetic basis for the production of toxic quinolizidine alkaloids in lupins

Lupins ( Lupinus spp.) are promising protein crops that accumulate bitter and toxic quinolizidine alkaloids (QAs). The effective removal of QAs through new breeding technologies is hampered by a poor understanding of their biosynthesis. In this study, we used pathway reconstructi...

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Investigating Potential Adverse Drug Reactions of Lisdexamfetamine Using Sequence Symmetry Analysis

ABSTRACT The prevalence of ADHD is increasing rapidly, and lisdexamfetamine is increasingly popular, but few studies investigate its safety. We performed a sequence symmetry analysis (SSA) using Danish register data to identify potential ADRs associated with lisdexamfetamine in 2...

Are Higher Suspicious Transaction Report Volumes Associated with More Future Money-Laundering Convictions?

Abstract Almost all countries require banks to file suspicious transaction reports (STRs) to help authorities detect and prosecute money laundering. The number of STRs filed in a country is an often-cited metric in international anti-money laundering (AML) compliance evaluations....

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...

Gold Contact Sensitization, Clinical Characteristics and Associations With Autoimmune Disease: A Retrospective Cohort Study With Registry Linkage

ABSTRACT Background Gold sensitization is common, but its clinical and immunologic significance remains unclear. European data from consecutively patch tested patients are scarce. Animal models suggest that gold can induce systemic autoimmunity, but studies in humans are limited....

Complete genome sequence and methylome analysis of Dermacoccus nishinomiyaensis strain 1-2 isolated from sushi

ABSTRACT Dermacoccus nishinomiyaensis is an actinomycete whose isolation from diverse environments and potential for opportunistic pathogenicity have been documented. Here, we report the complete genome sequence of D. nishinomiyaensis 1-2, isolated from sushi. We provide annotati...

Remote sensing and deep learning for standing dead-tree detection and mapping: a review of advances, challenges, and future directions

Standing dead trees are visible indicators of tree mortality and an important transitional component linking forest disturbance to future lying deadwood, habitat availability, and carbon storage. As drought, insect outbreaks, pathogens, and climate extremes intensify tree mortali...

Corticosteroid treatment modulates immune cell populations in the glioblastoma microenvironment

Abstract Background Corticosteroids play a crucial role in alleviating tumor-associated edema in patients with brain tumors. However, their impact on the tumor microenvironment within glioblastoma remains largely unexplored. In the context of increasing interest in immunotherapy...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Adaptive cut reveals multiscale complexity in networks

Abstract Hierarchical clustering and community detection are important problems in machine learning and complex network analysis. A common approach to identify clusters is to simply cut dendrograms at some threshold. However, single-level cuts are often suboptimal in terms of cap...