University of Copenhagen

Distinct body mass index trajectories throughout childhood in girls with early puberty

Abstract Background Early pubertal development in girls has been associated with increased adiposity in childhood. However, longitudinal body mass index (BMI) trajectories preceding the diagnosis of precocious puberty (PP) or premature adrenarche (PA) are less well described. We...

Extending single-cell proteomics from HeLa to small primary human immune cells

Abstract Single-cell proteomics (SCP) holds the promise of decoding cellular heterogeneity at the functional level, yet achieving deep and reproducible proteome coverage from individual cells has remained a formidable challenge. Here, we establish a high-sensitivity, label-free S...

Oral health and oral microbiota composition in patients with Parkinson’s disease: a case‒control study

Introduction Parkinson’s disease (PD) is associated with motor and non-motor dysfunctions that may influence oral homeostasis. An altered microbiota has been linked to PD, yet oral microbial changes remain poorly characterized. This case‒control study aimed to determine if the or...

Mules in the Antiquity of Southern Iberia revealed from proteomics

The management of equids in the Iberian Peninsula during the Iron Age (first millennium BCE) provides a key archaeological context for investigating the emerging stages of confluent breeding of horses ( Equus caballus ) and donkeys ( Equus asinus ). This scenario provided the ear...

Quality in Palliative Care for Patients With Pre-existing Severe Mental Disorders – A Questionnaire Study With Danish Health Care Professionals

Background Patients with severe mental disorders (SMDs) face disparities in end-of-life care, yet knowledge about the quality of palliative care is limited. Aims This study examined healthcare professionals’ perspectives on palliative care for patients with SMDs. Methods Question...

Do we need dark emotional energy? A comment on “ Rituals of Resentment”

Kallio and Törnberg argue that incel communities generate a distinctive form of dark emotional energy through interaction rituals organized around shared negativity and suffering. This comment acknowledges the importance of their analysis of solidarity premised around negative fe...

Psychology as Narrative: Understanding Our Science as Reflexive Worldmaking

Narratives structure, give meaning, and create possibilities in our lives. They direct our lived experiences throughout the life-course. As people, researchers draw on narratives to frame our sense-making of societal, cultural, and psychological phenomena, and they inform the sco...

Exercise-based cardiac rehabilitation for coronary heart disease

RATIONALE: Coronary heart disease (CHD) is the leading cause of death globally. CHD mortality rates remain steady in low- and middle-income countries but are declining in high-income countries, meaning more people are living with CHD and need support to manage their symptoms and...

Competing discourses about language, immigration, and integration in Norwegian media

Abstract Media discourse has been an important site of investigation in attempts to understand the semiotic dimensions of power relations, including in analyses of ways in which linguistic and social hierarchies are discursively forged and contested. In this article, I examine No...

Incidentally detected vertebral fractures and risk of myeloma: a prospective cohort study of 9059 CT-scanned Danish general population individuals

Vertebral fractures are frequently detected incidentally on computed tomography (CT) scans performed for other indications in individuals with no symptoms of a fracture [ 1 ]. In myeloma, >45% of patients have vertebral fractures at the time of myeloma diagnosis [ 2 ]. However, t...

Beyond “White Flight”: school mobility and local school attendance among native and immigrant families in Oslo, Norway

This article investigates how school choice contributes to processes of social and ethnic segregation in the context of Oslo, Norway – a city marked by strong egalitarian welfare traditions, a comprehensive public education system, but high levels of residential and school segreg...

Immune regulation includes an effector arm: therapeutic implications of phase III IDO/PD-L1 vaccination in melanoma

In a recent phase III study in Annals of Oncology , first-line IDO/PD-L1 peptide vaccination plus pembrolizumab in advanced melanoma provided clinical support for a microenvironment-targeting vaccine strategy. The broader significance of these data is that they support immune mod...

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation

Abstract Objective To quantify the survival benefit of deceased donor kidney transplantation versus continued dialysis according to patients’ characteristics (age, diabetes, cardiovascular disease), donor quality (standard criteria donor or expanded criteria donor) and donor retr...

No group-level changes in corticospinal excitability following low-intensity theta-burst ultrasound stimulation of the primary motor hand area

Abstract Low-intensity transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique offering high spatial precision and depth penetrance. Theta burst TUS (tbTUS), featuring a temporal theta burst stimulation pattern, has been reported to facilitat...

Exploring Relational Dynamics in Global Institutional Partnerships: A Protocol for a Multi-Method Qualitative Study of Capacity Strengthening

Capacity strengthening is widely invoked within global health and development, yet the concept lacks a shared foundation. Its inconsistent use, coupled with limited theoretical and methodological development, hampers efforts to establish equitable and well-functioning collaborati...

Intention-like representations in language models?

Abstract A growing chorus of AI researchers and philosophers posit internal representations in large language models (LLMs). But how do these representations relate to the kinds of mental states we routinely ascribe to our fellow humans? While some research has focused on belief-...

Gas absorption of soft X-rays strongly impacts the redshift distribution of dark Fast X-ray Transients

Abstract The progenitors of many Fast X-ray Transients (FXTs) and those of γ-ray bursts (GRBs) are strongly linked. Given that ”dark” GRBs are typically found to be events suffering from enhanced extinction in the host galaxy, we investigate the nature of ”dark” FXTs. However, un...

Net carbon losses in Central African forests revealed by high-resolution biomass change maps

Dense humid forests in Central Africa hold vast biomass carbon stocks but are increasingly affected by small-scale disturbances that are difficult to detect with current satellite observations. Here, we generate 10 m canopy height maps for 2019–2022 using deep learning with space...

Early Multicentre Outcomes of Endovascular Aortic Arch Repair Using a Custom-Made Triple-Branch NEXUS TRE Endograft System (TRE-ASURE Study)

Objective: To report the first multicentre European experience with the custom-made NEXUS TRE triple-branch endograft for fully endovascular, debranch-free repair of complex aortic arch pathology, focusing on technical feasibility and early safety outcomes. Methods: This retrospe...

Impaired Lung Function in Liver Transplant Recipients Compared With the General Population: A Nationwide Matched Cohort Study

Background. Liver transplant recipients have elevated risk of acute pulmonary infections, but the burden of chronic pulmonary diseases in liver transplant recipients remains largely unknown. We aimed to determine the association between living with a transplanted liver and both s...