University of Copenhagen

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

Blood Pressure Targets During General Anaesthesia in High‐Risk Patients—A Randomised Clinical Feasibility Trial

BACKGROUND: There is limited high-quality evidence to guide haemodynamic and respiratory management during general anaesthesia. The goal of this trial was to test the feasibility of testing different ventilatory settings and blood pressure targets. Previous trials on blood pressu...

Occupational exposure to noise and depression incidence: a nationwide cohort study of workers in Denmark, 2000–2017

Objectives Research on the association between occupational noise and incident depression is limited. We investigated whether long-term occupational noise was associated with depression risk, both independently and in combination with other stress-related factors. Methods In a Da...

Transthoracic drainage of lung abscesses (TOLA): protocol for a national multicenter randomized open-label trial

Introduction Lung abscess (LA) is a rare but severe necrotizing pulmonary infection associated with substantial morbidity and mortality. Current management relies on prolonged systemic antibiotic therapy without systematic use of abscess drainage. However, small case series and r...

Strengthening the engagement of mass media stakeholders in community-based health promotion interventions - the Danish Project SoL

<title>Abstract</title> <bold>Background</bold>: The potential positive effects of mass media stakeholders in health promotion have long been recognized. Health promotion interventions may benefit from exposure in mass media by attracting public attention and political support. M...

Brick kilns across India: A temporal analysis of brick kiln distribution and technology types

Thousands of brick kilns operate across India, significantly contributing to air pollution and CO 2 emissions due to outdated practices and non-compliance with environmental standards. Regulations promoting cleaner kiln technologies have been introduced, yet detailed information...

Explaining Urban Recovery after Tropical Cyclones: A Bibliometric-Systematic Review of Research Trends, Drivers, and Future Directions

Tropical cyclones increasingly threaten coastal cities, yet why recovery outcomes diverge across places remain poorly synthesized. Here we examine the determinants of post-cyclone urban recovery through a bibliometric-systematic review of 117 peer-reviewed empirical studies publi...

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage

Summary UV or gamma irradiation, as well as certain chemicals, generate DNA damage that disrupts transcription through a variety of well-characterised mechanisms. In contrast, the transcriptional response to oxidative stress remains poorly understood. Here, we describe a rapid an...

Prevalence, Incidence and Mortality of Chronic Kidney Disease in Type 1 and Type 2 Diabetes—A Nationwide Danish Register‐Based Cohort Study

ABSTRACT Aims Chronic kidney disease (CKD) remains a leading complication of diabetes, and understanding population‐level trends is crucial for prevention and healthcare planning. We examined national trends in CKD prevalence, incidence, and mortality among people with diabetes....

Getting Around the Intrinsic Errors of Density Functional Theory Calculations in Electrocatalysis

Abstract This article shows that the intrinsic gas-phase error in density functional theory (DFT) calculations can be effectively eliminated by referencing adsorption energies and reaction barriers to surface-bound intermediates rather than to molecular species. In oxygen reducti...

Exercise training during hospitalization in community-acquired pneumonia: effects on functional ability, body composition, and physical activity level

Abstract Background Physical inactivity contributes to functional decline and is associated with increased risk of adverse outcomes in patients hospitalized with community-acquired pneumonia (CAP). Exercise programs applied during acute hospitalization may mitigate these effects,...

Severity and resource utilisation among trauma patients undergoing trauma team activation in four Danish trauma units: a prospective cohort study

Evidence on trauma epidemiology and outcomes largely originates from major trauma centres, while data from regional trauma units remain limited. The aim of this study was to describe the epidemiology, management, and outcomes of patients undergoing trauma team activation in the t...

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years. The...

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers typically have lost the sperm storage organ,...

Exposure to workplace bullying and violence/threats of violence and subsequent working life expectancy among older workers: A Swedish prospective cohort study

OBJECTIVES: This study aimed to quantify possible associations between exposure to workplace bullying and violence, or threats thereof, and working life expectancy (WLE) among older workers in Sweden. METHODS: We conducted a prospective cohort study using data on 12 920 individua...

Environmentally induced dynamics between intraindividual variation and trait means across vegetative, phenological, and floral traits

PREMISE: Intraindividual variation in reiterated structures (e.g., leaves) represents an important dimension of phenotypic variation that contributes to functional diversity and the dynamics of ecological communities. It can be expressed differently across plant traits, but how e...

Aging is associated with altered estrogen receptor expression and alters redox protein balance in human female skeletal muscle

Abstract It has been hypothesized that age‑related declines in skeletal muscle and vascular function in females may be partly estrogen‑dependent. This study investigated skeletal muscle protein expression of estrogen receptor α (ERα), estrogen receptor β (ERβ), and G protein–coup...

Navigating the Battlefield: How Social Media Platforms Respond to Governance Demands From Legitimacy Communities in Geopolitical Conflicts

ABSTRACT Social media platforms have become central actors in governing online speech during geopolitical conflicts, navigating complex governance demands from diverse stake‐holding communities including states, civil society, and users. This paper explores these dynamics through...

The postsynaptic scaffolding protein SAPAP3 shapes mitochondrial activity: the case of Huntington’s disease

Abstract Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiol...

Benchmarking short-read germline structural variant calling highlights advantages of using ensembles of tools and small impact of graph genome alignment

Structural variants (SVs) in the human genome play an important role in health and disease. Identification of SVs is commonly performed using short-read sequencing. However, because sequenced fragments are typically shorter than the variants themselves, accurate SV calling remain...