University of Copenhagen

The lived experience of trans persons: a bottom-up review co-written by experts by experience and academics.

We present here the first bottom-up review of the lived experience of trans persons, co-written by experts by experience and academics. We sourced the medical and non-medical literature, focusing on first-person narratives, and critically extracted experiential themes, which were...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

Lifting the maximally-entangledness assumption in robust self-testing for synchronous games

Robust self-testing in non-local games allows a classical referee to certify that two untrustworthy players are able to perform a specific quantum strategy up to high precision. Proving robust self-testing results becomes significantly easier when one restricts the allowed strate...

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

Spatiotemporal dynamics of the barley rhizosphere prokaryotic community following repeated inoculation with Ensifer meliloti Rm2011 in a three-year field study

Abstract Background and aims Microbial inoculants are increasingly recognized for enhancing crop productivity and sustainable agriculture. We assessed the rhizosphere competence of Ensifer meliloti Rm2011 in different barley genotypes following repeated inoculation in three growi...

Mass and functionality based exergy analysis of different rapeseed protein production routes

Rapeseed proteins are among the outstanding plant-based proteins due to their favorable interfacial functionality. This study evaluates the resource use of the most common rapeseed protein production routes – acidic precipitation, ultrafiltration and wet mild fractionation – usin...

Depression, anxiety and PTSD symptoms in patients following emergency surgery: A systematic review and meta-analysis

Emergency surgery represents a major stressor that may increase the risk of adverse mental health outcomes. This systematic review and meta-analysis aimed to assess the incidence of clinically significant symptoms of depression, anxiety and PTSD after emergency surgery and the as...

Integrative holo-omic data analysis predicts interactions across the host-microbiome axis

Understanding the interplay between host organisms and their microbiomes is central to the development of sustainable food systems. However, high dimensionality and spurious associations remain major obstacles to extracting meaningful biological insight from multi-omic host-assoc...

Indeterminate Jacobi operators II

Abstract We consider the Jacobi operator ( T , D ( T )) associated with an indeterminate Hamburger moment problem, and present countable subsets S of the domain D ( T ) such that $${{\,\textrm{span}\,}}(S)$$ span ( S ) is dense in $$\ell ^2.$$ ℓ 2 . As an example we have $$S=\{(p...

Exploring the Feasibility and Acceptability of Compassion and Mindfulness Training for Adolescents With Type 1 Diabetes and Their Caregivers

AIM: To examine the feasibility and acceptability of mindfulness training for adolescents with Type 1 diabetes (T1D) and compassion training for caregivers. METHODS: Adolescents aged 12-17 years with T1D, and their caregivers were recruited from two diabetes centres between 2022...

Sensory Living Lab for Developing Innovative Berry-Based Food Products with High Consumer Acceptance

Abstract:Polish berry fruits, including blackcurrant, chokeberry, and haskap berry (Lonicera caerulea L.), are valuable raw materials for the development of innovative functional foods due to their high content of phenolic compounds and anthocyanins. These fruits exhibit strong a...

Carbon source-dependent metabolic states govern redox homeostasis and cofactor biosynthesis in Propionibacterium freudenreichii

ABSTRACT Microbial adaptation to fluctuating nutrient and oxygen conditions requires coordinated regulation of the metabolic network to maintain redox homeostasis within physicochemical and energetic constraints. While oxygen-dependent responses in Propionibacterium freudenreichi...

Glutamate levels in antipsychotic-free, first-episode psychosis: a 7-tesla MRS study across five brain regions

Disrupted glutamatergic signaling across cortical and subcortical circuits is increasingly recognized as a critical player in the pathophysiology of psychosis. Using ultra-high-field (7 Tesla) proton MRS, we quantified glutamate levels across five brain regions in antipsychotic-f...

From Paperclips to Premature Trust: Reconciling Divergent Views on AI Risk

Two prominent narratives about artificial intelligence risk, Bostrom's superintelligence scenario and the increasingly influential claim that the more pressing danger is premature trust in ordinary present-day systems, are often treated as competing diagnoses, and Gans's (2018) f...

Discovery through citizen science: Cryptocoryne paglaterasiana (Araceae), a new endangered species from Tampilisan, Zamboanga del Norte, Western Mindanao

Cryptocoryne paglaterasiana, a new endemic species discovered by two citizen scientists in Zamboanga del Norte, Western Mindanao, Philippines is herein described and illustrated. A detailed description, colour plates, phenology, distribution, provisional conservation status and a...

Short‐Term Clinical Outcomes and Complication Timing in Patients With Postoperative Delirium After Major Emergency Abdominal Surgery: A Prospective Cohort Study

ABSTRACT Background Postoperative delirium is linked to increased morbidity, mortality, and prolonged hospitalization; however, its short‐term consequences after major emergency abdominal surgery remain insufficiently studied. Methods This prospective cohort study included 752 pa...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Long-term Mortality and Shock-rate in Patients Surviving Out-of-Hospital Cardiac Arrest with and without early implantation of an Implantable Cardioverter Defibrillator

Introduction In patients who survive out-of-hospital cardiac arrest (OHCA), guidelines for implantation of an implantable cardioverter-defibrillator (ICD) are not unequivocal.Methods Patients resuscitated from OHCA of cardiac cause, without a reversible cause and an expected surv...