University of Copenhagen

A temporal differentiation program after birth delineates γδ T cell immunity

Type 1 and type 3 γδ T cells develop in the embryonic thymus, yet it is not known whether they continue to differentiate after birth in tissues. Here, we show that in the first week of life, intestinal γδ T cells up-regulated many T cell activation and type 3 genes, while the pos...

The Zooplankton International Geospatial dataset: A global repository of spatiotemporal freshwater zooplankton community composition data from lakes and reservoirs to support ecological research

Abstract Zooplankton transfer substantial energy in aquatic food webs and are used as indicators of environmental change. Syntheses of zooplankton community dynamics globally require datasets that span a wide range of environmental gradients; however, these datasets are limited d...

Associated prognostic impact of opioid use before Transcatheter aortic valve implantation – A Danish nationwide cohort study

Background Opioid use is frequently reported as a baseline characteristic in transcatheter aortic valve implantation (TAVI) cohorts, yet its prognostic implications have not been examined. Aim To examine the association between pre-procedural opioid use and post-TAVI outcomes. Me...

The Price of a Horn: How Governance and Policy Shape an Illegal Wildlife Market

ABSTRACT Understanding the determinants of illegal rhino horn prices can provide information for the design of policies to conserve wild rhinoceroses. Using a theoretical model, we identify empirical measures that may affect illegal rhino horn prices and derive testable hypothese...

Accelerating biomass loss from forest disturbances across Europe

Abstract Forest disturbances are rising globally due to climate change and land-use pressures, weakening the terrestrial carbon sink. However, declines in aboveground biomass from tree cover loss remain poorly quantified, limiting our understanding of the role of disturbances in...

CNS migration of Diplostomum pseudospathaceum in rainbow trout: neuro-immunological interactions

Abstract Rainbow trout Oncorhynchus mykiss serves as second intermediate host to the eyefluke Diplostomum pseudospathaceum , which resides as the metacercarial stage in the fish lens. The parasite uses a fish-eating bird as the definitive host and a pulmonate lymnaeid snail as fi...

Adult mental health service outcomes for patients of child and adolescent mental health services: a total Scottish birth cohort study

Abstract Child and adolescent mental health services (CAMHS) provide a critical opportunity for early mental health interventions. Evidence is still scare, however, on the long-term mental health outcomes of CAMHS patients, including their subsequent adult mental health service u...

Serial cardiac ultrasound in acutely ill adults: a systematic review

Background Cardiopulmonary symptoms frequently prompt emergency department (ED) visits. Serial as-sessment of dynamic cardiac ultrasound parameters may support monitoring, but their asso-ciation with patient outcomes and role in guiding management is uncertain. This systematic re...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...

Nerve Injury Following Birth, the Role of Epidural Analgesia—A Protocol for a Scoping Review

BACKGROUND: Epidural analgesia is widely used during labor, and postpartum nerve injury is an uncommon but clinically relevant outcome. Neurological symptoms after childbirth may be related to obstetric or anesthetic factors. Studies vary considerably in how postpartum nerve inju...

Predicting future risk of type 1 and type 2 diabetes after gestational diabetes mellitus using polygenic scores: a cohort study

AIMS/HYPOTHESIS: Women with previous gestational diabetes mellitus (GDM) have an increased risk of developing both type 1 and type 2 diabetes. However, predicting the risk on a personal level is challenging. Polygenic scores (PGSs), which capture an individual's genetic susceptib...

Achieving micrometer-scale 4D X-ray tomography of living leaf tissue in the laboratory

A methodology for achieving micrometer-scale 4D X-ray lab microscopy of living leaf tissue was developed to overcome challenges associated with delicate tissues, radiation damage, and motion artifacts during in vivo imaging. The study focused on optimizing laboratory-based X-ray...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...

The Past, Present, and Future of Online Biodiversity Knowledge Systems

In recent decades, the availability and accessibility of biodiversity data and the profusion of portals, tools, and platforms through which to utilize them have increased rapidly. This reflects the extensive variety of challenges biodiversity data are being used to address and th...

Automation and autocommunication: A typology of self-communication with wearables

This is a preprint of an article submitted for consideration in the International Journal of Communication.

Stochasticity in response to rostrocaudal and mediolateral determinants influences inaccurate specification within kidney organoids

The differentiation of human pluripotent stem cells to kidney requires the accurate recapitulation of complex morphogenetic patterning events within an in vitro environment. Current protocols are assumed to accurately pattern through intermediate mesoderm to kidney with outcomes...

MicroRNA signatures of equine asthma phenotypes in serum and bronchoalveolar lavage fluid

Equine asthma (EA) is a highly prevalent, chronic, inflammatory disease of the lower airways ranging from mild-to-moderate to severe clinical presentations. Diagnosis currently relies on bronchoalveolar lavage fluid (BALF) cytology, an invasive method associated with interobserve...

Development and validation of a theoretical test for ultrasound-guided biopsy competence in the head and neck

PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...

Effect of Case Variation on Mastoidectomy Training Using 3D‐Printed Temporal Bones Models—A Prospective, Randomized Trial

Abstract Objective To investigate effects of repeated training with anatomically varied versus identical 3D‐printed models on skill acquisition, cognitive load, and skill retention in novice mastoidectomy trainees. Study Design A prospective, randomized, controlled, educational t...

Automation and autocommunication: A typology of self-communication with wearables

This is a preprint of an article submitted for consideration in the International Journal of Communication.