University of California, San Francisco

Mind the Gap: Disparities in Education on Organ Donation and Transplantation-Results of a Global Survey.

Background: Widely accessible education on organ donation and transplantation (ODT) is a tool to reduce waiting lists, as <10% of transplant needs are met (Global Observatory on Donation and Transplantation). We aimed to assess the current state of access to education on ODT worl...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

Acceptance of Organs From Deceased Donors: Results of a Global Survey.

Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We assessed knowledge and com...

Intrinsic Tension Drives Palatal Shelf Reorientation post Tongue Retraction

Cleft palate can be caused by failure of elevation of the palatal shelves over the tongue during development. The physical mechanism of elevation is poorly understood. It is thought that elevation is obstructed by the tongue in a condition known as Pierre Robin sequence (PRS), in...

Trends in annual medication possession in older adults with type 2 diabetes

BACKGROUND: Older adults (≥65 years) make up a substantial portion of individuals with type 2 diabetes (T2D) and frequently experience multimorbidity requiring complex, costly medication regimens. Cost-related nonadherence is prevalent in this population because of fixed incomes,...

Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in a multiethnic US population

Abstract Neuroinflammation is associated with depression and anxiety risk, both of which demonstrate a bilateral relationship with cardiometabolic disorders. Systemic inflammation was also commonly described in patients with cardiometabolic disorders. It is, thus, unclear whether...

Infections in MonumenTAL-1: a plain language summary of talquetamab treatment for relapsed/refractory multiple myeloma

Plain Language SummaryWhat is this summary about?This summary describes infection and immune cell data of participants receiving talquetamab for relapsed/refractory multiple myeloma (RRMM) in the MonumenTAL-1 study.What were the results?Almost 60% of participants receiving talque...

Brain Penetrant Calcium Channel Blockers Were Not Associated With Reduced Alcohol Consumption: Converging Results From Two Large Independent Cohort Studies Using Electronic Health Records

ABSTRACT Purpose Alcohol use disorder (AUD) remains a major public health problem, with few effective treatments. L‐type calcium channel blockers (LTCCBs) have genetic and preclinical support as potential treatments for AUD. Methods We evaluated whether brain penetrant (BP)‐LTCCB...

Before lowering blood pressure to prevent ARIA, we need evidence of net benefit

Amyloid-related imaging abnormalities (ARIA) occur in 20-40% of patients treated with the amyloid-targeting drugs lecanemab and donanemab. While most cases of ARIA are asymptomatic, serious and fatal cases occur. Therefore, ARIA prevention remains vital as these drugs are increas...

Before lowering blood pressure to prevent ARIA, we need evidence of net benefit

Amyloid-related imaging abnormalities (ARIA) occur in 20-40% of patients treated with the amyloid-targeting drugs lecanemab and donanemab. While most cases of ARIA are asymptomatic, serious and fatal cases occur. Therefore, ARIA prevention remains vital as these drugs are increas...

Associations of metformin-based antidiabetic combinations and Alzheimer’s disease onset: a retrospective EHR cohort study

Abstract Background Type 2 Diabetes (T2D) is an established risk factor for dementia and Alzheimer’s Disease (AD). Previous literature primarily examines the neuroprotective benefits of antidiabetic medications (metformin, SGLT2 inhibitors, and GLP-1 receptor agonists) in isolati...

All Hypoglycemia Is Not Created Equal

A Proposed Hypoglycemia Taxonomy: Differences in Frequency, Detection, and Evidence of Harms.

Cataract surgery in the United Kingdom: patient characteristics, surgical patterns, and clinical outcomes in the National Health Service and a private-sector provider

To describe differences in patient population, practice patterns and outcomes between private and public setting cataract surgery. Preoperative population and clinical outcomes from the Royal College of Ophthalmologists National Ophthalmology Database study (2010 NOD; surgeries A...

Firearm owners’ support for policies regulating firearms left in vehicles

Abstract Purpose Firearms stolen from vehicles are a leading source of gun theft in the US. In response, there has been growth in the number of proposed and enacted policies at the state and local levels. Yet firearm owners’ attitudes toward policies regulating firearms left in v...

Water-Enabled Conversion of NO and CO to NH3 over CuO x Clusters via Hydrolysis of Surface –NCO Intermediates

Abstract The catalytic conversion of gaseous NO to NH3 offers a promising dual-benefit strategy for environmental remediation and sustainable chemical synthesis. Herein, CuO/Al2O3 catalysts with varied CuO loadings (x wt %, xCu/Al) were developed for the possible NH3 production f...

Optical microscopy predictions of focal recurrence in glioblastoma

A hallmark of glioblastoma (GBM) is disease recurrence that occurs in all patients despite resection, radiation, and chemotherapy. A critical challenge in GBM treatment is the management of recurrent disease for which no standard of care exists. Predicting the location of GBM rec...

A design approach for bitopic kinase inhibitors

Abstract Traditional kinase inhibitors face a trade-off between potency and selectivity because their affinity depends on limited molecular interactions in a single highly conserved binding site. Bitopic inhibitors overcome this limitation by engaging multiple sites on the same t...

Comparative effectiveness of GLP-1 receptor agonists, SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas on weight change among people with HIV: a real-world longitudinal cohort study

Obesity is common among people with HIV (PWH), yet evidence on weight loss with newer antidiabetic medications in this population is limited. We compared bodyweight change associated with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium–glucose cotransporter-2 (SGLT2)...

Single-nucleus transcriptome-wide association study of human brain disorders

Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many...