University of California, San Francisco

Moving Upstream: Perinatal Cash Transfers as a Tool to Address Inequities in Birth Outcomes

The United States has an exceptionally high preterm birth rate, which features inequities that impact many Black, Indigenous, and Pacific Islander families. Unconditional perinatal cash transfers, which offer cash assistance to pregnant and postpartum women with no strings attach...

Serum Leptin and Thyroid Levels in Hospitalized Patients With Severe Eating Disorders

ABSTRACT Objective Leptin and thyroid hormones are interrelated regulators of energy homeostasis that are altered during starvation, yet their within‐subject trajectories during early nutritional rehabilitation in severe restrictive eating disorders (EDs) remain poorly understood...

Contingency Management for Smoking Cessation Among Adults Experiencing Homelessness

Importance: More than 70% of people experiencing homelessness report current smoking. Contingency management (CM) interventions that provide financial incentives for smoking cessation have shown short-term promise, but extended CM interventions have not been well studied in this...

Bias in Cohort Studies: The Critical Importance of the “Why” and “When” of Treatment Decisions

When it comes to high-quality, rigorous research, children generally get the short end of the stick. Randomized controlled trials (RCTs)—the “gold standard” for clinical research1—are rare in this population.2 RCTs are expensive, time-consuming, and often fraught with ethical con...

Community-Based Surgery and Postoperative Survival Among Veterans Affairs Enrollees

Importance: The Veterans Affairs Maintaining Internal Systems and Strengthening Integrated Outside Networks (VA MISSION) Act of 2018 greatly expanded Veterans Affairs (VA) enrollees' access to non-VA (community care) services. Since then, community-based utilization has increased...

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides

Approximately 30% of tumors contain an activating mutation in the oncogene KRAS, leading to increased cell proliferation that often promotes non-small cell lung cancers, colorectal adenocarcinomas, pancreatic ductal adenocarcinomas (PDAC), and other cancers. Among the most common...

Electrostatically Limited PFSA Ionomer Adsorption to Catalyst Particles in Catalyst Inks

Abstract Understanding and controlling ionomer adsorption in catalyst inks is critical to optimizing catalyst-layer structure and performance in membrane-electrode assemblies. Here, we systematically quantify perfluorosulfonic-acid (PFSA) ionomer adsorption across a diverse set o...

Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity

Abstract Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present st...

Evaluating large language model performance in US FDA regulatory science

Abstract Background Clinical and population decision-making relies on the systematic evaluation of extensive regulatory evidence. The FDA drug reviews provide detailed information on clinical trial design, enrollment criteria, sample size, randomization, comparators, endpoints, a...

Catalyst Control of Alkylbenzene Molecular Architecture in Tandem Catalytic Hydrogenolysis-Aromatization of Polyethylene

Abstract Upcycling of polyethylene (PE) can transform waste material into chemically valuable building blocks such as linear alkylbenzenes, with potential use in anionic surfactants. Alkylbenzenes can be formed by tandem hydrogenolysis-aromatization of PE, catalyzed by Pt nanopar...

Examining the Sustained Impact of California’s Tobacco Free for Recovery Initiative: Qualitative Perspectives from Program Directors

Background: Smoking prevalence among people in substance use treatment is substantially higher than the national average. Residential substance use treatment represents an opportune time to address this disparity. California launched the Tobacco Free for Recovery Initiative to he...

Impact of alcohol use discontinuation on adipose tissue insulin resistance among Latino patients with and without underlying chronic liver disease

Abstract We evaluated the effect of short-term moderate alcohol discontinuation on adipose tissue insulin resistance (adipo-IR) and factors associated with its change in Latinos with and without hepatitis C virus (HCV). Nondiabetic Latino adults without (N = 17) or with (N = 7) H...

Arterial Spin‐Labeling MRI at the Cortical‐ CSF Interface: A Novel Biomarker in Alzheimer Disease

BACKGROUND/OBJECTIVE: Arterial spin-labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF-adjacent water transport physiology. We developed an automated pipeline to extract cortical-CSF interface (IF) perfusion for compar...

Evaluation of the Relative Citation Ratio Versus the H-Index as Measures of Citation-Based Scholarly Influence in Academic Neurosurgery

BACKGROUND AND OBJECTIVES: Evaluating citation-based scholarly influence among academic faculty is foundational to academic medicine, as retention, promotion, and tenure to govern career advancement at every level. The h-index has been the standard metric across fields, including...

Developing interactive learning interfaces for teaching AI in health professions education using generative AI tools

Health professions education (HPE) must now equip students to use artificial intelligence (AI) tools safely. We offer an instructional design strategy for HPE educators aiming to teach fundamental AI concepts to non-technical audiences: using generative AI to rapidly create inter...

Human spinal interneurons repair the injured rat spinal cord through synaptic integration

Spinal cord injury (SCI) results in irreversible disruption of motor, sensory, and autonomic circuits with no approved reparative treatment to restore lost function. Endogenous V2a spinal interneurons (SpINs) have been implicated as a key component in recovery post-SCI, but the i...

Heterogeneous human muscle fibroadipogenic progenitors include a DLK1 + subpopulation that prevents fatty infiltration after injury

Fatty infiltration and fibrosis drive poor outcomes after chronic muscle injury. Here, we characterized fibroadipogenic progenitor cell (FAP) subpopulations from healthy and injured human rotator cuff muscle by single-cell RNA sequencing, full-spectrum flow cytometry, and functio...

Assessing acuity in pediatric emergency department triage: performance of a large language model

Pediatric triage performance varies across emergency departments (ED), contributing to ongoing challenges in pediatric emergency care. There is growing interest in using large language models (LLMs) to support more consistent triage decision-making in children. We evaluated an LL...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia

Importance: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. Objective: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization. Design, S...

Papillary Hyperplasia in Autosomal Dominant Polycystic Kidney Disease

Renal cysts in autosomal dominant polycystic kidney disease (ADPKD) frequently harbor small intracystic epithelial proliferations that arise in continuity with the cyst lining and are distinct from other recognized proliferative lesions or well-defined renal tumors and lack a for...