University of California, San Francisco

Accurately modeling RNase H-mediated antisense oligonucleotide efficacy.

, achieving a 5.72-fold reduction in screening effort compared to random selection. ASO Atlas provides the first systematic resource to rigorously evaluate hypotheses regarding key parameters in ASO design, including sequence composition, chemical modifications, and target region...

Rebuilding Trust in the Patient-Physician Relationship

This Viewpoint discusses the need to rebuild, enhance, and sustain patient-physician trust and explores various initiatives that are being implemented to address this need.

Evaluation of a Rapid Immunoassay for Molecular Subphenotype Classification in Pediatric Acute Cardiorespiratory Failure

OBJECTIVES: Molecular subphenotypes, identified through latent class analysis (LCA) of biomarker profiles, have the potential to guide targeted therapeutics in critical care. We have previously published that intensive insulin management has subphenotype-specific beneficial effec...

Cu-Catalyzed Funneling Oxidation Enables C–C Bond Cleavage in Lignin-derived Compounds

Abstract The structural complexity and chemical heterogeneity of lignin present a formidable barrier to its use as a sustainable replacement for petroleum-derived aromatics. Here, we report a robust, earth-abundant copper/nitroxyl catalytic system that achieves the aerobic oxidat...

A cluster-randomized controlled trial of a family-based psychosocial intervention to prevent childhood obesity from preschool ages: the PRESAFALIN study protocol

Abstract Background: Childhood obesity is a major global concern, and Spain's high obesity rates highlight the urgent need for effective and innovative interventions in early age. The PRESAFALIN study aims to promote parental competence, self-efficacy, and resilience to improve c...

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

OBJECTIVES: Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes. The objective o...

Ibrutinib therapy results in atrial fibrillation through modulation of the Src-Erk1/2 pathway

The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has revolutionized treatment for B-cell malignancies but increases the incidence of atrial fibrillation (AF) compared to conventional chemotherapy. The downstream signaling pathways through which ibrutinib leads to AF are unk...

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

The ends of human chromosomes are capped by specialized nucleoprotein structures, termed telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide resolution, uncovering ext...

MIR192 upregulates GLP-1 receptor and rescues statin-induced impairment of insulin secretion

Abstract Background Statins are a commonly prescribed cholesterol-lowering drug class that can increase the risk of new-onset diabetes (NOD). The underlying molecular mechanisms have yet to be fully elucidated. We aimed to identify molecular factors associated with differential s...

Analysis of the Political Viewpoints of Policy Statements from Professional Nursing Organizations Using ChatGPT-5: A Cross-Sectional Study

This policy analysis utilized a large language model to identify criteria to assess for the presence or absence of political bias and to categorize bias where present in the public policy statements issued by six major nursing organizations.

Navigating mental health care: latine perceptions, barriers, and pathways to engagement

Background: Latine individuals in the U.S. experience similar or higher rates of depression compared to non-Hispanic Whites but remain less likely to receive timely or effective mental health care. While structural and cultural barriers have been well-documented, limited research...

A stakeholder-engaged process to design and implement the Assessment of Cognitive Complaints Toolkit for Alzheimer’s Disease (ACCT-AD) in primary care

Background: Dementia is underdiagnosed, particularly in primary care settings where most people receive their healthcare. These is a need for tools to assist with the diagnosis of dementia by primary care clinicians, who greatly outnumber specialists. Objective: To describe the c...

Exploring the Association Between Colorectal Cancer Metastasis and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Nationwide Analysis

Background: Metabolic syndrome-associated conditions and malignancies frequently co-exist, influencing each other’s progression, severity, and prognosis. This study evaluates whether metabolic dysfunction-associated steatotic liver disease (MASLD) contributes to an increased risk...

HIV Testing and Care Among Publicly Insured Enrollees With Schizophrenia: Is There a Benefit to Dual Eligibility?

Background Patients with schizophrenia experience gaps in the human immunodeficiency virus (HIV) care continuum. We examined the impact of dual enrollment in Medicare upon HIV testing and retention among Medicaid‐enrolled patients with schizophrenia. Methods Using Medicaid Analyt...

State-Level Abortion Policies and Infant Health Outcomes

Importance Previous research has found associations between abortion policies and infant health. Differing methods complicate understanding which abortion policies matter for infant health. Objective To examine associations between multiple state-level abortion policies and infan...

Greater D3-Creatine Muscle Mass and MRI Thigh Muscle Volume are Associated with Higher Bone Strength in Older Adults: Exploratory Findings in The Study of Muscle, Mobility and Aging (SOMMA)

Abstract Low bone mineral density (BMD) and impaired bone strength are established risk factors for fractures in older adults. Decreased muscle size also contributes to fracture risk, however, the relationship between muscle size and bone density, microarchitecture, and strength...

Omic risk scores are associated with COPD-related traits across three cohorts

Background: Chronic obstructive pulmonary disease (COPD) exhibits marked heterogeneity in lung function decline, mortality, exacerbations, and other disease-related outcomes. Omic risk scores (ORS) estimate the cumulative contribution of omics, such as the transcriptome, proteome...

Participant perspectives on a person-centred care model for mobile individuals in HIV care from the SEARCH Dynamic Choice Treatment trial in rural Kenya and Uganda

Introduction Mobile populations experience difficulties maintaining antiretroviral therapy (ART) adherence and HIV care engagement. We sought to explore participant perceptions of a patient-centred model aimed at enhancing care engagement through ‘dynamic choice’ treatment servic...

The impact of social protection interventions on treatment and socioeconomic outcomes of tuberculosis-affected people and households in low income, high burden settings: A systematic review and meta-analysis

Abstract Introduction Tuberculosis (TB) is the leading cause of death due to infectious disease worldwide. Social protection interventions can benefit TB-affected households. We conducted a systematic review and meta-analysis to quantify the effectiveness of social protection on...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...