University of California, San Francisco

Health Literacy and Other Factors Associated With Recent Dental Care Utilization Among Mexican-American Adults

Introduction and Aims Health literacy (HL) plays a role in determining whether patients can successfully navigate dental care systems and access needed care. This study examines the association between HL on recent dental care utilization among Mexican-American young adults durin...

Social Risk Screening and Referrals in the Pediatric Inpatient Setting

BACKGROUND/OBJECTIVES: Many professional organizations recently recommended inpatient screening for social risks. Although prior studies have explored social risk screening rates in children's hospitals, many excluded community hospitals and lacked detail on screening practices....

A modular in-incubator microscope for longitudinal live-cell microscopy

Longitudinal live-cell imaging is valuable for characterizing morphological and phenotypic changes in biological systems. However, conventional approaches rely on manual microscope operation, which is labor-intensive, limits imaging frequency, and disrupts cellular environments....

The impact of non-medical determinants of health on patient-reported outcomes in pediatric lupus: A CARRA registry study

Objectives Social determinants of health (SDOH) and race are associated with disease activity, including lower achievement of the low lupus disease activity state (LLDAS), but it is unknown whether these factors are associated with patient-reported outcomes (PROs). Among a cohort...

Disruption of the CRL5 ubiquitin ligase complex enhances engineered T-cell persistence under chronic tumor antigen exposure

Abstract Engineered T-cell therapies are limited by progressive dysfunction under chronic tumor antigen exposure, and genetic perturbation of negative regulators has emerged as a promising strategy to sustain effector activity. We reanalyzed a genome-wide CRISPR knockout screen i...

Trichoblastic Carcinoma Arising Within a Trichoepithelioma: A Biphasic Follicular Neoplasm With Compartment-Specific CK15, CK20, and Ki-67 Findings

Abstract: Trichoblastic carcinoma (TBC) is a rare malignant follicular neoplasm whose distinction from trichoblastoma/trichoepithelioma (TE) and basal cell carcinoma may be challenging. We report an 83-year-old woman with a nodule on the left superior parietal scalp suspected cli...

Cullin-5 RING E3 ligase limits CD8⁺ T-cell persistence and effector responses during chronic antigen stimulation

Abstract T-cell exhaustion limits durable antitumor responses and remains a barrier to adoptive cell therapies (ACT) in solid tumors. To identify regulators of T-cell persistence, we performed genome-wide CRISPR knockout screens in primary human CD8⁺ T cells expressing an NY-ESO-...

Redefining Kidney Stone Incidence: Emerging Age-Related Patterns

OBJECTIVE: To evaluate the association between age and incident kidney stone disease using contemporary, age- and sex-stratified population-based data from the UK Biobank. METHODS: We undertook a cohort study of 494,745 UK Biobank participants after excluding 7406 individuals wit...

Photomapping electrically coupled networks of the mature thalamus and cortex

Electrical synapses are expressed ubiquitously across the brain and are crucial components of active neural circuitry and connectomes. Identification of coupled networks in living tissue is limited by technical demands of multiplexed recordings, and no dyes, fluorescent reporters...

Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging

Most neurodegenerative diseases reflect patient-specific combinations of polygenic risk variants interacting with aging and environmental factors, rather than a single causative mutation. Phase III clinical trial failure rates for neurodegenerative indications exceed 95%, reflect...

Developing a drug-level feedback adherence counseling intervention for young MSM in the U.S.

Background: Young men who have sex with men (MSM) in the U.S. have suboptimal adherence to oral tenofovir-based pre-exposure prophylaxis (PrEP), undermining HIV prevention goals. Drug-level feedback using urine point-of-care tenofovir assays has improved adherence in Eastern and...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Hemispheric Asymmetry of Neuroimaging Biomarkers in Early Onset Alzheimer's Disease: Clinical and Cognitive Outcomes

Objective Individuals diagnosed with Alzheimer's disease (AD) often exhibit amyloid, tau, and atrophy predominantly in the left or right hemisphere, but group‐level analyses typically ignore inter‐individual variability and changing asymmetry patterns when averaging data across p...

Sex work or male-with-male sexual activity and the risks of HIV and hepatitis C acquisition among people who inject drugs: a global systematic review and meta-analysis

Background People who inject drugs (PWID) may engage in sexual behaviours that increase their HIV and hepatitis C virus (HCV) risk, including sex work and male-with-male sexual activity. We undertook a global systematic review to assess whether PWID who engage in these behaviours...

Infantile Hemangiomas

This Patient Page describes the types and treatment of infantile hemangiomas.

Health services intervention integrating HTN and HIV care improves long-term blood pressure control among people living with HIV in Uganda

Background Globally, the prevalence of hypertension (HTN) among people with HIV (PWH) has increased dramatically over the last decade. In a cluster randomized trial, we evaluated the effect of a multicomponent intervention model on blood pressure (BP) control among PWH in rural U...

Percutaneous Coronary Intervention Facility Access and Clinical Outcomes Among Patients With Acute Myocardial Infarction

Importance The proliferation of percutaneous coronary intervention (PCI) facilities across the US has raised questions about whether expanding capacity improves outcomes in areas already served vs those without prior access. Objective To evaluate the association between the openi...

Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three virtual screens

Abstract Accurate prediction of ligand-bound protein complexes and ranking them by affinity are central problems in drug discovery. While deep learning co-folding methods can help address these challenges, their evaluation has been hampered by the difficulties in assessing indepe...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...

β3‑adrenergic receptor agonist improves recovery after volumetric muscle loss and is associated with increased intramuscular brown/beige adipogenic activity in mice

Abstract Background Volumetric muscle loss (VML) often results in chronic muscle weakness, limb dysfunction, and even permanent disability. Current research primarily focuses on cell and extracellular matrix transplantation, but there is a lack of studies on the physiologically s...