University of California, San Francisco

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease

Alzheimer’s disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on populatio...

Reducing Ultraprocessed Foods From the Diets of Patients With Depression

This pilot crossover trial assesses the feasibility and acceptability of removing ultraprocessed foods from the diets of patients with major depressive disorder.

Redirecting Carbon Flux Toward 2-Ketoglutarate Enables Photoautotrophic 1,4-Butanediol Production from CO2

Abstract Engineered cyanobacteria offer a sustainable platform for the conversion of light and CO2 into value-added chemicals. Unlike heterotrophic systems, cyanobacteria do not require organic carbon sources such as glycerol, glucose, or sucrose. In this study, we engineered Syn...

Single-cell atlas of transcriptomic vulnerability across brain disorders

Abstract Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited 1,2 . Here, to gain deeper insights into the aetiolo...

Understanding the Microscopic Structure of Counterion Condensation Near a Charged Polypeptoid Surface

Abstract The molecular-level study of the electrical double layer is key to understanding ion solvation, adsorption, and transport in many electrochemical and biological systems. Here, we combine the modified Gaussian renormalized fluctuation theory and molecular dynamics simulat...

Comparative effectiveness of GLP-1 receptor agonists, SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas on weight change among people with HIV: a real-world longitudinal cohort study

Obesity is common among people with HIV (PWH), yet evidence on weight loss with newer antidiabetic medications in this population is limited. We compared bodyweight change associated with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium–glucose cotransporter-2 (SGLT2)...

Guiding Risk Reduction for Breast Cancer-Relevant Chemicals (BC-Chems): Chemical Production Volumes, Sources, Intake Levels, Emissions, and Regulations

Abstract Breast cancer (BC) among women in all age groups continues to increase. Changes in reproductive risk factors cannot explain these trends, and rising rates among women under 40 cannot be explained by cancer screening, suggesting other factors are involved. We recently ide...

A design approach for bitopic kinase inhibitors

Abstract Traditional kinase inhibitors face a trade-off between potency and selectivity because their affinity depends on limited molecular interactions in a single highly conserved binding site. Bitopic inhibitors overcome this limitation by engaging multiple sites on the same t...

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal...

Engineered pediatric human muscle models the interferon-driven transcriptome of juvenile dermatomyositis

Abstract Juvenile dermatomyositis (JDM) is a rare pediatric autoimmune disease characterized by a strong type I interferon (IFN) signature in muscle. Mechanistic and therapeutic discovery has been limited by the lack of a clinically relevant disease model. To address this, we tes...

Blood proteomics of menopause map to brain aging and dementia risk

Abstract Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated wit...

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults with Systemic Lupus Erythematosus

OBJECTIVE: To characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement-medication interactions among adults with systemic lupus erythematosus (SLE). METHODS: We analyzed cross-sectional data from 4...

Social Determinants of Health and Neurocognitive Aging in Indigenous and Non-Indigenous Older Adults in Rural Andean Ecuador: A Population-Based Study in Cotacachi

Introduction: Social determinants of health shape dementia risk in Latin America, particularly in rural and Indigenous populations. Methods: This cross-sectional study examined cognitive impairment and associated social factors in 75 adults aged 60 years or older in Cotacachi, Ec...

Presence of a trusted adult and adolescent health outcomes in Urban India

Adolescents in urban India face significant challenges in accessing healthcare and reliable health information, particularly during crises such as the COVID-19 pandemic. However, the role of trusted adults in shaping adolescent health remains underexplored. This study examined he...

Observation of Weak Driving-Force Dependence of Hydride Formation with Iron Carbonyl Clusters

Abstract Metal-hydride formation reactions are common elementary reactions in catalytic systems, including fuel formation and organic transformations. Here, metal-hydride formation rates with metal carbonyl clusters [Fe4N(CO)12]− and [Fe5N(CO)15]− were determined in MeCN and aque...

Promoting Optimal Pediatric Readiness at US Trauma Centers: Understanding and Addressing Barriers

Children treated at facilities prepared to provide emergency pediatric care have improved outcomes, but access to pediatric-ready care remains inconsistent. A multidisciplinary spotlight session at the 2026 American College of Surgeons Committee on Trauma Annual Meeting examined...

Harm Reduction Vending Machines in Supportive Housing for Veterans

Importance Harm reduction vending machines (HRVMs) are an evidence-based strategy to provide low-barrier access to harm reduction and health supplies; however, little is known about their perceived impacts in permanent supportive housing for US veterans. Objective To evaluate vet...

Familial Influences on Adolescent E-Cigarette and Cannabis Use: A Qualitative Analysis

Family factors influencing adolescent cigarette smoking are well described, but specific family influences of e-cigarettes and cannabis behaviors are underexamined. The objective of this study was to explore the role of family in adolescent e-cigarette, other tobacco, and cannabi...

Measuring Sunscreen Reflectance and White Cast Using an In Vitro Skin Tone Model

Sunscreen white cast is a visible whitening on skin caused by light scattering from sunscreen films and is one of the primary reasons consumers underapply sunscreen below the 2 mg/cm2 thickness required to achieve labeled SPF. Existing methods for quantifying white cast rely on i...

Dissipative Quantum Algorithms for Excited-State Quantum Chemistry

Abstract Electronic excited states are central to a vast array of physical and chemical phenomena, yet accurate and efficient methods for preparing them on quantum devices remain challenging and are comparatively underexplored. We introduce a general dissipative algorithm for sel...