University of California, Los Angeles

Approved Medications for Substance Use Disorders: An Umbrella Review of Systematic Reviews and Completed Phase 3 Randomized Controlled Trials

This umbrella review of systematic reviews, meta-analyses, and completed phase 3 randomized controlled trials (RCTs) over the past 10 years covers approved pharmacological treatments for substance use disorders (SUD) worldwide, providing clinicians and researchers with a detailed...

Advances in Biomarker Discovery for Cardiovascular Disease

Cardiovascular disease remains one of the leading causes of morbidity and mortality worldwide, representing a major global public health challenge [...]

Multifocal Musculoskeletal Invasive Group A Streptococcal Infection in Previously Healthy Children

Background: Multifocal musculoskeletal invasive group A streptococcal (iGAS) infection is a severe and infrequently reported presentation in children. We describe 2 previously healthy pediatric patients with multifocal musculoskeletal iGAS infection and compare their presentation...

Simulating Bouncing Packets Driven by Ducted Lightning‐Generated Whistlers: Comparison With SAMPEX Observations

Abstract Bouncing packets are quasi‐periodic microbursts separated by the electron bounce period. Solar Anomalous and Magnetospheric Particle Explorer observations revealed relativistic (>1 MeV) inner‐belt bouncing packets with “crown,” “decaying,” and “flat” envelopes. We test w...

Scaled-down model test research on effective ratio of transverse bending stiffness for large-diameter shield tunnel

the effective ratio of transverse bending stiffness ( η ) is a key parameter in the modified conventional method for segments of large-diameter shield tunnel, and it significantly influences the internal forces of these segments. Based on similarity theory (with the tunnel joint...

Scalable, energy-efficient optical-neural architecture for multiplexed deepfake video detection

Abstract The rapid proliferation of AI-generated visual media has created an urgent need for efficient, trustworthy deepfake detection systems. However, existing deep learning–based detection methods rely on computationally intensive and energy-demanding inference algorithms, lim...

A graph neural network surrogate for traffic simulation in probabilistic wildfire evacuation planning

Agent-based traffic simulation is one of the main computational bottlenecks in probabilistic wildfire evacuation frameworks that rely on Monte Carlo analysis to populate Bayesian network models. This paper presents a graph neural network (GNN) surrogate that replaces it within th...

Effect Decomposition of Functional-Output Computer Experiments via Orthogonal Additive Gaussian Processes

Functional ANOVA (FANOVA) is a widely used variance-based sensitivity analysis tool. However, studies on functional-output FANOVA remain relatively scarce, especially for black-box computer experiments, which often involve complex and nonlinear functional-output relationships wit...

LEVERAGING A NETWORK OF EHR-LINKED BIOBANKS TO INVESTIGATE CLINICAL AND GENETIC RISK FOR PERINATAL DEPRESSION

Perinatal depression (PND) is a depressive illness occurring during pregnancy and up to one year following childbirth. PND affects 10-20% of mothers and can contribute to maternal mortality and morbidity, as well as adverse outcomes in children. Despite increasing interest in ris...

Polycyclic aromatic hydrocarbons, gut microbiome composition, impulsivity, and attention covary in a human cohort

ABSTRACT Polycyclic aromatic hydrocarbons (PAHs) are pervasive environmental pollutants linked to adverse neurobehavioral outcomes, yet the biological pathways coupling exposure to behavior are poorly defined. The gut microbiome is both sensitive to PAH exposure and a modulator o...

Nonlocal dielectric response and screening in ionic liquids

The dielectric response of room-temperature ionic liquids (RTILs) plays a central role in charge screening within these strongly correlated ionic fluids and thereby governs ion transport, electrochemical kinetics, solubility, and related electrochemical phenomena. Here, we presen...

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Letter to University of Montreal – Address to Our Supervisors Team

In this paper, We are addressing a note to University of Montreal, mainly our Supervisors : Professor [bilodeau@dms.umontreal.ca],Professor [duchesne@dms.umontreal.ca], and Professor [murua@dms.umontreal.ca], Professor Perron [perronf@dms.umontreal.ca],Professor David [dhaziza@uo...

Risk of psoriasis in patients treated with dupilumab for bullous pemphigoid: A cohort study

The data underlying this article were provided by TriNetX under licence and by permission. Data sharing upon request to TriNetX via the corresponding author.

Diffuse uterine leiomyomatosis with a mesenteric smooth muscle lesion and a reported family history of uterine leiomyomas: a case report and literature review

Abstract Background Diffuse uterine leiomyomatosis (DUL) is a rare benign smooth muscle disorder characterized by diffuse proliferation of innumerable, poorly circumscribed leiomyomatous nodules throughout the myometrium. Because its clinical and radiologic features overlap with...

Hepatocellular Carcinoma With a Grade 3 Neuroendocrine Tumor Component: A Case Report

Mixed hepatocellular carcinoma (HCC) and neuroendocrine tumor (NET) constitute an exceedingly rare and diagnostically challenging entity. We report a 70-year-old man with hepatitis C-related cirrhosis and multifocal HCCs, who was status post multiple microwave and radiofrequency...

Letter to University of Montreal – Address to Our Supervisors Team

In this paper, We are addressing a note to University of Montreal, mainly our Supervisors : Professor [bilodeau@dms.umontreal.ca],Professor [duchesne@dms.umontreal.ca], and Professor [murua@dms.umontreal.ca], Professor Perron [perronf@dms.umontreal.ca],Professor David [dhaziza@uo...

Strengthening Youth Crisis Reporting and Response: Development of a Practice-Based Systems Maturity Model

Youth suicide prevention and crisis response require coordinated action across public health, behavioral health, education, health care, law enforcement, and community systems. However, local jurisdictions often lack practical tools to assess system readiness and prioritize syste...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...