University of California, Los Angeles

The Nuances of Cost-Related Medication Non-Adherence in Patients Receiving Immunosuppression Compared to Patients with Chronic Disease: A Cross-Sectional Study

Background: Medication adherence rates across diseases that require immunosuppression, including autoimmune diseases, are low. While cost barriers affect medication adherence, it is unknown whether adherence rates related to cost barriers differ between medically immunosuppressed...

Regio- and Enantioselective Functionalization of Gaseous Alkanes via Nickel-Catalyzed Alkene Dicarbofunctionalization

Abstract The regio- and enantioselective functionalization of gaseous alkanes remains an unsolved challenge in organic synthesis. Here, we report a general strategy for the asymmetric three-component dicarbofunctionalization of alkenes using readily available gaseous alkanes, inc...

Gamified Augmented Sensorimotor Feedback During Balance Training Improves Postural Control and Nocturnal RMSSD

Background and Objectives: Augmented sensorimotor feedback may enhance motor learning during balance training, but whether these adaptations extend to cardiac autonomic regulation remains unclear. This study compared wobble-board training with gamified augmented feedback versus c...

Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial

Introduction Vestibulodynia (VBD) is a common chronic pelvic pain condition with heterogeneous clinical presentation, including subtypes distinguished by the presence (VBD-central; VBD-c) or absence (VBD-peripheral; VBD-p) of comorbid pain conditions. Despite frequent prescribing...

“My Existence is Queer”: Understanding Trans and Nonbinary College Students’ Sexual Identities

Scientific practices surrounding sexual identity are largely based upon cisheteronormative assumptions, using terms that may not resonate with − or may exclude − trans and nonbinary (TNB) individuals and their experiences. This exploratory study examined how TNB college students...

Self‐Monitoring of Blood Pressure: A Qualitative Study From Iraqi and Syrian Refugees

Background Self‐measured blood pressure (SMBP) monitoring improves long‐term blood pressure (BP) outcomes, but evidence on the acceptability and feasibility of SMBP in refugee populations is limited. Refugees face high cardiovascular risk due to poorly controlled BP. Methods We r...

Adjuvant Systemic Hypothermia During Mechanical Thrombectomy (ReCCLAIM II): A Multicenter, Randomized, Controlled Trial

BACKGROUND: Hypothermia reduces ischemic injury in preclinical stroke models, yet translation into the clinical setting remains challenging. We aimed to assess the feasibility of inducing adjuvant systemic hypothermia among patients with large-vessel occlusion stroke during mecha...

Costly missed connections: Visitation and misconduct in California prisons

Social isolation is a major public health crisis with particularly deleterious consequences for vulnerable populations including incarcerated people. Theoretically, visitation from family should reduce social isolation and improve outcomes among incarcerated people, but existing...

Medical School Performance Evaluations (MSPEs) Lack Objectivity: A Challenge in the Surgery Residency Selection Process

IMPORTANCE In the past several years, the methods used to evaluate medical students have undergone significant shifts. The United States Medical Licensing Examination Step 1 grading has become pass/fail, as has clinical grading at many institutions. Residency program directors ha...

Diagnosis and management of transthyretin amyloidosis (ATTRv) across ATTRv-PN and mixed phenotype: an international delphi consensus

Abstract Background Transthyretin amyloidosis is a progressive, potentially fatal genetic disorder primarily associated with polyneuropathy (ATTRv-PN) or cardiomyopathy (ATTR-CM). Disease presentation is heterogenous. Patients often present with a mixed phenotype. Although recent...

Antarctic sea ice over the past 130 000 years – Part 2: A review of its role in the Earth system

Abstract. Antarctic sea-ice cover reached historically low levels in 2023, consistent with the simulated decrease in sea-ice extent in response to anthropogenic warming. Antarctic sea ice is closely linked to multiple components of the Earth system, thus its demise could precipit...

Increases in Regional Brain Volume and Thickness Following ECT and Relationships With Changes in Depressive Symptoms and Peripheral Inflammation

OBJECTIVES: Treatment-resistant depression (TRD) is highly prevalent and debilitating. Electroconvulsive therapy (ECT) is an efficacious intervention for TRD. This study sought to clarify ECT's mechanisms by examining relationships between ECT-induced changes in regional brain vo...

Neural Repair Therapies After Stroke: I. Therapeutic Advances

Stroke is a leading cause of disability worldwide. Neural repair therapies, distinct from acute stroke therapies, target surviving neural elements to promote plasticity after the acute injury has occurred. Repair therapies encompass a broad and rapidly evolving therapeutic landsc...

Effect of Age on Physical Function Improvement in Older Veterans Enrolled in the Gerofit Exercise Program

Background/Objectives: Aging is associated with declines in strength, balance, and mobility that contribute to falls, disability, and loss of independence. While exercise interventions improve physical function, limited data exist on community-dwelling adults aged 90 years and ol...

RINGSIDE Phase II Study of Varegacestat for Treatment of Desmoid Tumors: A Randomized Dose-Finding Clinical Trial

PURPOSE Desmoid tumors (DTs) are rare, often locally aggressive, connective tissue neoplasms with limited effective treatment options. We evaluated the safety and efficacy of varegacestat, an oral gamma-secretase inhibitor. METHODS RINGSIDE phase II was an open-label, randomized,...

Spiritual assessment in mental health care: a review of current practices and future directions

Spirituality plays an increasingly recognised role in psychiatric recovery, resilience, and meaning-making. This article reviews the rationale, tools, challenges, and ethical imperatives for integrating spiritual assessment into psychiatric care. A literature review was conducted...

Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus

Infectious disease severity, shedding, and within-host kinetics can vary substantially with exposure dose, inoculation route, and host factors. However, the relative contributions of these variables to infection heterogeneity remain poorly quantified because small sample sizes in...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Ex situ thermal acclimation alters temperature selection with limited post-release effects in an endangered frog ( Rana muscosa )

Abstract Amphibian declines driven by the fungal pathogen Batrachochytrium dendrobatidis (Bd) pose major challenges for conservation, particularly for cold-adapted species occupying habitats where temperatures may be less limiting to Bd growth. Host thermal behaviour can influenc...

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...