University of California, Los Angeles

Diffuse uterine leiomyomatosis with a mesenteric smooth muscle lesion and a reported family history of uterine leiomyomas: a case report and literature review

Abstract Background Diffuse uterine leiomyomatosis (DUL) is a rare benign smooth muscle disorder characterized by diffuse proliferation of innumerable, poorly circumscribed leiomyomatous nodules throughout the myometrium. Because its clinical and radiologic features overlap with...

Letter to University of Montreal – Address to Our Supervisors Team

In this paper, We are addressing a note to University of Montreal, mainly our Supervisors : Professor [bilodeau@dms.umontreal.ca],Professor [duchesne@dms.umontreal.ca], and Professor [murua@dms.umontreal.ca], Professor Perron [perronf@dms.umontreal.ca],Professor David [dhaziza@uo...

Risk of psoriasis in patients treated with dupilumab for bullous pemphigoid: A cohort study

The data underlying this article were provided by TriNetX under licence and by permission. Data sharing upon request to TriNetX via the corresponding author.

Hepatocellular Carcinoma With a Grade 3 Neuroendocrine Tumor Component: A Case Report

Mixed hepatocellular carcinoma (HCC) and neuroendocrine tumor (NET) constitute an exceedingly rare and diagnostically challenging entity. We report a 70-year-old man with hepatitis C-related cirrhosis and multifocal HCCs, who was status post multiple microwave and radiofrequency...

Letter to University of Montreal – Address to Our Supervisors Team

In this paper, We are addressing a note to University of Montreal, mainly our Supervisors : Professor [bilodeau@dms.umontreal.ca],Professor [duchesne@dms.umontreal.ca], and Professor [murua@dms.umontreal.ca], Professor Perron [perronf@dms.umontreal.ca],Professor David [dhaziza@uo...

Large Language Model Data Abstraction Demonstrates Accuracy and Reliability for NSQIP

Background: National Surgical Quality Improvement Program (NSQIP) data collection depends on labor-intensive manual chart abstraction, limiting efficiency, increasing cost, and necessitating patient sampling. This study evaluated whether a large language model (LLM) could accurat...

Interlayer-engineering of charge order wavevector in kagome metals

Charge orders in the kagome metals AV$_3$Sb$_5$ sit at the center of a rich phase diagram that also includes superconductivity, nematicity, and signatures of time-reversal-symmetry breaking. Yet even the basic question of which charge ordering wave vectors are intrinsic, and whic...

Strengthening Youth Crisis Reporting and Response: Development of a Practice-Based Systems Maturity Model

Youth suicide prevention and crisis response require coordinated action across public health, behavioral health, education, health care, law enforcement, and community systems. However, local jurisdictions often lack practical tools to assess system readiness and prioritize syste...

Ultrahigh flow strength in shocked nanopolycrystalline diamond

Extreme pressures and temperatures create conditions that allow even hard and brittle materials to flow plastically. Despite extensive research, the limits of flow strength under such conditions remain uncertain, and the mechanisms driving deformation at the relevant stresses are...

Coenzyme A activates TLR4 and enhances alternative macrophage activation in line with MyD88 agonism

Abstract Metabolites and metabolic cofactors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofactor coenzyme A (CoA) enhances IL-4 driven alternative macrophag...

GTPase cycle and ER membrane regulate cargo handover during cotranslational protein targeting

Signal recognition particle (SRP), a universally conserved protein-targeting machine, cotranslationally recognizes signal sequences of nascent endomembrane proteins and engages the SRP receptor (SR) at the endoplasmic reticulum (ER) membrane to unload the translating ribosome. Th...

Geometry-controlled instability pathway selection in elastic helices enables fast, efficient robotic locomotion

Mechanical instabilities can convert slow actuation into rapid, amplified motion, but predicting whether a three-dimensional elastic structure buckles smoothly or snaps remains challenging. Here, we show that helix geometry and boundary loading jointly select continuous buckling...

Cerebrovascular and behavioral changes in the nitroglycerin mouse model of migraine

Abstract Background Nitroglycerin (NTG) is an established human migraine trigger, and administration in rodents is a commonly used migraine model. While the sensory sensitivity that occurs in response to NTG in rodents has been extensively studied, other physiological and behavio...

Do Autistic Adolescents Talk Differently in Same-Sex Versus Mixed-Sex Conversations?

Autistic individuals often struggle with social communication, but the nature of each person’s difficulties varies substantially by context. Recent conversation-based research suggests that males and females (autistic and nonautistic) produce subtle but consistent differences in...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

“Provided power is there, it will be a good initiative”: healthcare provider perspectives on diagnostic screening for curable STIs during pregnancy in Botswana

Diagnostic screening for curable sexually transmitted infections (STIs) during antenatal care has the potential to improve health outcomes among women and infants in low- and middle-income countries (LMICs). To inform roll-out and scale up of antenatal STI screening in LMICs, it...

A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers

Background Viral infections associated with hemorrhagic fevers (VaHFs) cause millions of cases each year across a broad geography with severity ranging from asymptomatic cases to clinical disease with a high case fatality rate. Commonalities in pathophysiology across VaHFs includ...

Event-triggered neural network adaptive hybrid attitude control

In this paper, we develop an adaptive controller for rigid-body attitude tracking systems that combines a neural network architecture with an event-triggered mechanism. We design a quaternion-based nonlinear controller that employs a neural network to compensate for state-based d...

The psychosocial impact of neurofibromatosis type 1: a narrative review

Abstract Neurofibromatosis type 1 (NF1) is a rare autosomal dominant (AD) genodermatosis characterized by café-au-lait macules (CALMs), cutaneous and plexiform neurofibromas, and cognitive impairments and neurodevelopmental disorders. As a rare genetic skin disease (RGSD), NF1 is...

Sleep Duration and Metabolic Biomarkers During Pregnancy: A Longitudinal Study in a Multiracial Cohort

Abstract Objective: To examine associations between sleep duration and metabolic biomarkers in pregnant women. Methods: This nested case-control study involved 321 pregnant women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth...