University of California, Los Angeles

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

Assessing the Validity of the Fixed Tree Topology Assumption in Phylodynamic Inference

Abstract Fixed tree topologies are widely used in phylodynamic analyses to reduce computational burden, yet the consequences of this assumption remain insufficiently understood. Here, we systematically assess the impact of various fixed-topology strategies on phylogenetic and phy...

Sensitivity of the Martian Magnetotail to Model Configuration Choices in Multispecies MHD Simulations

Abstract Numerical modeling has been a key component in the study of the Mars space environment, providing a comprehensive global representation that is not always easy to obtain in spacecraft measurements. However, there are inconsistencies in data‐model and model‐model comparis...

Inverse design of bespoke interatomic potentials via active learning by information-matching

Interatomic potentials (IPs) enable large-scale atomistic simulations beyond the reach of first-principles methods, but their predictive reliability depends critically on the selection of training data, quantified uncertainty, and model expressiveness. Active learning (AL) provid...

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis r...

The Equity‐Minded Board? Leadership, Accountability, and the Future of Community College Governance

ABSTRACT This study examines how community college governing boards can advance racial equity by extending Bensimon's equity‐mindedness to the level of institutional governance. Using document analysis of California Community Colleges (CCC) Board of Governors (BOG) policies and g...

Needs assessment of medical curricula development for patients with physical, intellectual, and/or developmental disabilities or non-english language preferences

Abstract Objective Individuals with physical, intellectual, and developmental disabilities (P/IDD) and those with non-English language preferences (NELP) experience significant health disparities, which have been traced to inadequacies in medical training. There is a need to crea...

The Art of Printing [3D Engineering & Advanced Geometry]

There are sequences of actions that we repeat everyday. Among them is the printing action: print a numeric paper in pdf format and save it on your computer, or print it using a Xerox Machine or HP-printer. We found out we can do More: Let us Print in 3D Dimension, and investigate...

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

ABSTRACT Synaptic dysfunction is a major driver of cognitive decline in Alzheimer's disease (AD), yet its extent and molecular basis in the retina remain poorly defined. We integrated postmortem retinal and matched brain histopathology with ultrastructural, proteomic, biochemical...

Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling

High-fructose corn syrup (HFCS) consumption is a risk factor for obesity and diabetes, yet the underlying mechanisms, especially at the specific organ level, are incompletely understood. Catabolism of dietary fructose primarily occurs in the small intestine and liver, with fructo...

Codebase release 1.0 for NLODIS

We present a numerical program that evaluates deep inelastic scattering (DIS) structure functions at next-to-leading order (NLO) accuracy in the dipole picture. In this numerical implementation the NLO DIS impact factors with massive quarks are written in a form that ensures a st...

A numerical implementation of the NLO DIS structure functions in the dipole picture

We present a numerical program that evaluates deep inelastic scattering (DIS) structure functions at next-to-leading order (NLO) accuracy in the dipole picture. In this numerical implementation the NLO DIS impact factors with massive quarks are written in a form that ensures a st...

Sociodemographic and Clinical Factors Associated With Nirsevimab Receipt Among Children Aged Younger Than 20 Months in the New Vaccine Surveillance Network in 2023 to 2025

OBJECTIVES: We aim to evaluate the association of sociodemographic and clinical factors with nirsevimab receipt among children with medically attended acute respiratory illness (ARI) across multiple seasons and beyond birth hospitalization. PATIENTS AND METHODS: We included nirse...

Engaging future scientists: the effect of science museum visits on high school students’ science identity development

Abstract Background Expanding participation in STEM fields has been a longstanding national priority, with growing attention to informal learning environments as contexts for fostering students’ science identity. Science museums offer hands-on, inquiry-based experiences that comp...

Atypical Cerebellar Responses are Associated with Altered Neural Habituation during Sensory Stimulation in Autism

Sensory processing atypicalities are highly prevalent in autistic youth; yet, the neural mechanisms underlying these differences are not well understood. While the cerebellum plays a key role in sensorimotor coordination and is structurally and functionally atypical in the autist...

The worst energy policy in the world

The Iran war could serve as a turning point in accelerating the global transition away from fossil fuels: Every additional day that oil and gas prices are high and future supplies are uncertain, wind and solar power—cheaper and more scalable than ever before—grow all the more app...

A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment

Importance Cascade genetic testing (CGT) is a key strategy for cancer prevention in families with hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), yet uptake among at-risk relatives remains persistently low, particularly in medically underserved popul...

Healthcare cultures and the implementation of WHA77.2: from measurement to institutional change

Resolution WHA77.2 establishes an unprecedented mandate for meaningful social participation in health decision-making. The resolution, and the operational guidance that preceded it, already address representation, power, deliberation, feedback, policy influence, and evaluation. I...

Timing of Parenteral Nutrition in Neonates, Infants, and Children: Current Evidence, Circadian Considerations, and Emerging Directions

Despite advances in parenteral nutrition (PN) formulations, the temporal aspects of PN delivery are less defined. This review synthesizes evidence on the optimal timing of PN initiation, duration, and delivery within the 24-h day in pediatric populations. Evidence suggests that t...

The relative Manin–Mumford conjecture

Abstract We prove the Relative Manin–Mumford Conjecture for families of abelian varieties in characteristic 0. We follow the Pila–Zannier method to study special point problems, and we use the Betti map which goes back to work of Masser and Zannier in the case of curves. The key...