Institution
University of California, Los Angeles
Recent research
- BiologyOpen access
MGN-3 (Biobran), a denatured hemicellulose compound derived from rice bran, possesses potent immunomodulatory and antitumor activity; however, its clinical application is constrained by non-specific tissue distribution, rapid systemic elimination, and poor cellular uptake. To ove...
- Society & EconomicsOpen access
Gravity is the shape of spacetime. The other three forces are not: they are rules attached on top of spacetime rather than properties of it, and physics has kept these two kinds of law in separate boxes for a hundred years. This paper closes the gap by making them two faces of on...
- Society & EconomicsOpen access
For half a century a quantum anomaly has been described as a flaw that shows up only when a classical symmetry is run through the quantum machine. This paper makes the opposite case: the anomaly is, at bottom, a classical and geometric fact about a higher-dimensional space, and t...
- Physics & SpaceOpen access
For forty years the standard model of cosmology, ΛCDM, has described the universe with breathtaking precision and explained almost none of it: a handful of numbers, read off the sky, reproduce everything — yet the theory cannot say why those numbers take the values they do. This...
- Physics & SpaceOpen access
Every particle discovered since the mid-1970s — the W and Z, the top, the Higgs — was on the Standard Model's list before it was found. This paper is about the first particle that is not on that list. GG-Theory derives, rather than fits, a new mass scale: the lock cluster at M_lo...
- Physics & SpaceOpen access
The Kaxion: Cold Dark Matter as the Non-Spatial Compact-Angle Pseudoscalar of GG-6
Nearly a century ago, astronomers found that galaxies move as though they hold far more matter than we can see. Stars at the edges of spinning galaxies orbit too fast; the afterglow of the Big Bang bears the imprint of a substance outweighing ordinary atoms five to one. We call i...
- Health & MedicineOpen access
OBJECTIVES: Molecular subphenotypes, identified through latent class analysis (LCA) of biomarker profiles, have the potential to guide targeted therapeutics in critical care. We have previously published that intensive insulin management has subphenotype-specific beneficial effec...
- Physics & SpaceOpen access
The Kaxion: Cold Dark Matter as the Non-Spatial Compact-Angle Pseudoscalar of GG-6
Nearly a century ago, astronomers found that galaxies move as though they hold far more matter than we can see. Stars at the edges of spinning galaxies orbit too fast; the afterglow of the Big Bang bears the imprint of a substance outweighing ordinary atoms five to one. We call i...
- Health & MedicineOpen access
Abstract This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of...
- Health & MedicineOpen access
Gendered racism, rooted in the interlocking injustices of racism and sexism, is a contributor to poor mental health; its association with physical health outcomes, however, is not well understood. This study investigates whether gendered racism is associated with disease activity...
- AI & Computing
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐base...
- Climate & EnvironmentOpen access
Developing quantitative relationships between functional traits and performance of tropical seaweed
The development of trait-based ecology has deepened our understanding of community response to environmental challenges. Here we provide a conceptual underpinning for seaweed trait-based ecology by establishing relationships between traits and performance. We conducted a field ex...
- Health & MedicineOpen access
Abstract We conducted a randomized surgical window-of-opportunity trial ( NCT04606316 ) in recurrent, resectable glioblastoma. Between 2021 and 2024, 71 patients were screened, and 63 were randomized (intention-to-treat [ITT] population), and 58 received study treatment. Patients...
- Climate & EnvironmentOpen access
Capability of Planet Dove for monitoring the world's coastlines
Coastal ecosystems worldwide are increasingly threatened by the impacts of climate and land use change, which alter habitat structure, disrupt ecological processes, and reduce ecosystem resilience. Satellite imagery provides an important tool for monitoring these changes and info...
- BiologyOpen access
Abstract Mutualistic networks provide essential contributions to long‐term ecosystem functioning and food security, but Anthropocene stressors continue to alter their structure and size. Previous theoretical approaches produce conflicting predictions for how network features infl...
- BiologyOpen access
Many computational predictors of missense variant pathogenicity are available. To capture information across various predictors, we propose MissenseHMM, which learns states corresponding to combinatorial patterns of variant prioritizations. We applied MissenseHMM to 43 predictors...
- Health & MedicineOpen access
Background Prosthetic joint infection (PJI) involves a significant mortality risk, with 26-30% of patients dying within 5 years. Current risk assessment tools offer limited prognostic accuracy for PJI patients. This study aimed to develop a prognostic model for 5-year all-cause m...
- Engineering & TechnologyOpen access
Hydrogrossular is the solid solution between Katoite (Ca 3 Al 2 (OH) 12 ) and Grossular (Ca 3 Al 2 (SiO 4 ) 3 ). The hydrogrossular series are major hydration products of calcium (sulfo)aluminate cement and are also present in traditional cement systems hydrated at elevated tempe...
- Society & EconomicsOpen access
Abstract Introduction Puerto Rico's Medicare Advantage market operates under a persistent yet fluctuating federal funding disparity, with reported benchmark payments approximately 38% below those in United States states. Health insurance industry representatives have argued that...
- Health & MedicineOpen access
Abstract Mechanosensitive (MS) channels are membrane proteins that respond to mechanical stimuli and are essential across prokaryotic and eukaryotic organisms. The E. coli mechanosensitive channel of large conductance (MscL) provides a powerful model for dissecting protein–lipid...