University of California, Los Angeles

Evaluation of a National Mentorship Pilot Program for Early-Career Women in PHM

BACKGROUND: Women comprise most of the pediatric hospital medicine (PHM) workforce yet experience disparities in authorship, leadership, and compensation. Structured mentorship and professional development tailored to early-career women remain limited. Supporting Her in Navigatin...

Machine Learning-Guided Scope Selection to Balance Performance and Substrate Similarity

Abstract The determination of a reaction substrate scope enables downstream users to assess whether a specific transformation is suitable for an intended application. The information content of this scope, characterized by its performance and structural diversity, is crucial to e...

Specialized Textiles Association

We have built a Playlist Videos from Youtube for Specialized Textiles Association. Some factories are concerned : H&M Foundation, Winners, etc

Specialized Textiles Association

We have built a Playlist Videos from Youtube for Specialized Textiles Association. Some factories are concerned : H&M Foundation, Winners, etc

DiploPhos: A Hemilabile Bisphosphine for Sterically Hindered Ni-Catalyzed Suzuki–Miyaura Couplings

Abstract Pharmaceutically relevant Suzuki–Miyaura cross-couplings (SMCs) often require designer phosphine ligands and palladium loadings above 1 mol % to couple Lewis basic, sterically congested substrates. Recent work has demonstrated that nickel is an attractive alternative to...

The new WHO infertility guideline: A universal right to equitable, evidence‐based fertility care

Abstract The WHO ‘Guideline for the prevention, diagnosis and treatment of infertility’ heralds a significant global shift towards recognizing infertility as a medical condition requiring prevention, diagnosis, treatment and policy support. This recognition is vital for the one i...

Plug-and-Play Image Restoration with Flow Matching: A Continuous Viewpoint

Abstract. Flow matching-based generative models have been integrated into the plug-and-play image restoration framework, and the resulting plug-and-play flow matching (PnP-Flow) model has achieved some remarkable empirical success for image restoration. However, the theoretical u...

Fatty Acid and Oxylipin Metabolism Differentiate Isolated Postcapillary From Combined Pre- and Postcapillary Pulmonary Hypertension

BACKGROUND: Pulmonary hypertension (PH) due to left-sided heart disease (Group 2 PH) is the most common type of PH and comprises 2 subtypes with distinct clinical profiles and outcomes: isolated postcapillary PH and combined pre- and postcapillary PH (Cpc-PH). Bioactive lipid der...

An Atlas of Specificity Protein 1 in Oral Cancer: Networks, Therapeutics, and Priorities: A Scoping Review and scRNA-seq Analysis

Oral squamous cell carcinoma (OSCC) remains the most common oral malignancy and has limited targeted therapeutic options. Specificity protein 1 (Sp1), a versatile zinc-finger transcription factor, has emerged as a pivotal regulator of cellular proliferation, apoptosis, epithelial...

Moderators of the Effects of Telehealth Mindfulness-based Interventions for Chronic Pain

OBJECTIVES: Little is known about who benefits most from Mindfulness-Based Interventions (MBIs), and whether certain groups differentially benefit from different types of MBI formats (group-based versus non-group based). The present study uses data from a three-arm randomized con...

In search of social belonging: a qualitative study of drivers of alcohol use and barriers to alcohol reduction among pregnant women in South Africa

Abstract Background Alcohol use during pregnancy remains a major public health concern in South Africa, particularly in communities with entrenched historical, social, and structural drivers of harmful drinking. Saldanha Bay, a peri-urban fishing community in the Western Cape, ha...

Optic Disc and Retinal Strain Due to Vertical Duction

Purpose: To compare two-dimensional optic disc and retinal vessel strains due to vertical versus horizontal eye rotations in younger and older subjects using confocal scanning laser ophthalmoscopy (cSLO). Methods: In a younger subject group (n = 10; range, 18-39 years; mean age ±...

Dimensions of early life adversity and accelerated biological aging in adolescents: an examination of fear-related mechanisms

Abstract Early life adversity (ELA), characterized by threat (experiences involving threat of harm), and not deprivation (absence of expected environmental inputs), has been associated with accelerated biological aging in youth. Although understanding of underlying processes is l...

Adamantyl-BOX Ligand Enabling Stereoselective Synthesis of Axially Chiral Aldehydes Bearing Vicinal Stereogenic Centers

Abstract Biaryl frameworks combining axial and multiple central chiralities are highly valuable in synthesis and drug discovery. However, simultaneous construction of axial and vicinal central chiralities faces severe matching/mismatching limitations. Herein, we describe a dual p...

Within-family effect of ancestry on complex traits in a Mexican population

Abstract Human populations differ in disease prevalence and phenotypes, but the extent to which differences are caused by genetic factors is unknown for most complex traits. Comparing phenotypic means across populations is confounded by environmental differences and using polygen...

HMMR+ stromal cells drive human uterine development

Abstract Early uterine development in humans is a critical determinant of reproductive health and disease susceptibility during adolescence. While single-cell analyses have extensively characterized the adult uterus, the developmental origins of this organ remain poorly understoo...

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

BACKGROUND: Evidence of the diverse genetic architecture of dilated cardiomyopathy (DCM) continues to emerge and requires reassessment of the clinical relevance of implicated disease genes. Building on the 2019-2020 Clinical Genome Resource evaluation, the DCM gene curation exper...

The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals

The distribution of fitness effects (DFE) describes the selection coefficients of newly arising mutations and fundamentally influences population genetic processes. However, the extent and mechanisms of differences in the DFE for non-synonymous mutations have not been systematica...

GG-Theory with GG-6: Geometry–Gauge Locking at the 6D Bulk (GG-6) at the Heart of Grand Geometric Theory (GG-Theory)

Gravity is the shape of spacetime. The other three forces are not: they are rules attached on top of spacetime rather than properties of it, and physics has kept these two kinds of law in separate boxes for a hundred years. This paper closes the gap by making them two faces of on...

The Kaxion: Cold Dark Matter as the Non-Spatial Compact-Angle Pseudoscalar of GG-6

Nearly a century ago, astronomers found that galaxies move as though they hold far more matter than we can see. Stars at the edges of spinning galaxies orbit too fast; the afterglow of the Big Bang bears the imprint of a substance outweighing ordinary atoms five to one. We call i...