University of California, Los Angeles

Trends in Intrauterine Device Use Before and After National Eligibility Guideline Changes.

OBJECTIVE: To examine changes in intrauterine device (IUD) use after national guideline updates (2010-2014) that expanded eligibility to include adolescents and nulliparous women in the United States. METHODS: Using cross-sectional data from the 2002-2023 waves of the National Su...

Takeoff of an all-polymer micro aerial flying robot

Flying insects are agile and can withstand impacts and compression because of their low inertia and resilient wings, exoskeletons, and muscles. These capabilities inspire the development of micro aerial vehicles (MAVs) for surveillance, disaster response, and environmental monito...

Validating Wing Biopsies for Blood‐Borne Pathogen Characterization in Bats

Wildlife surveillance is critical for tracking disease emergence, characterizing pathogen diversity, and assessing spillover risks. Blood-borne pathogens are of particular interest for such efforts due to their global distribution, broad host taxa, and zoonotic potential. Despite...

Comparative Renal Effectiveness of GLP-1RA and SGLT2i in US Veterans with Type 2 Diabetes and CKD

Objective: To address limited comparative evidence in older, clinically complex patients with type 2 diabetes and moderate-to-advanced chronic kidney disease (CKD), we compared nephroprotective outcomes after GLP-1RA versus SGLT2i initiation among US Veterans aged ≥65 years with...

Distance-Based Representation Learning with Nonlinear Feature Algebras

Abstract Graph neural networks and spectral embeddings aggregate local neighbourhoods and so miss the global metric properties—growth rate, hyperbolicity, boundary at infinity—that govern large-scale structure in hierarchical, networked, and negatively curved data. We propose a f...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Patents on Small-Molecule Drugs Approved by the US Food and Drug Administration, 1990-2019

Importance Patent protection allows pharmaceutical companies to charge high prices for prescription drugs during periods of market exclusivity, and their expiration usually defines when generic competitors can enter the US market. Patents on drug active ingredients are classified...

Experimental Evidence for the Impact of Copper Microstructure on Residual Stress of Through Silicon Via

ABSTRACT Three‐dimensional integrated circuits (3DICs) with Cu through silicon vias (TSVs) offer improved system performance beyond front‐end‐of‐line scaling. However, the residual thermal stress imparted by TSVs on the surrounding silicon raises reliability concerns. This stress...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Multilingual Hispanic Speech in California (MuHSiC): A Large-Scale Open-Access Spanish–English Bilingual Corpus

Aims and Objectives / Purpose / Research Questions: This article introduces the Multilingual Hispanic Speech in California (MuHSiC) corpus. It addresses two primary questions: (a) how can a large-scale, open-access corpus be designed to capture the linguistic diversity of Spanish...

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

The 2026 Bundibugyo virus disease (BVD) outbreak in the DRC and Uganda raises urgent questions about the efficacy of existing Ebola virus (EBOV) monoclonal antibodies (mAbs) against Bundibugyo virus (BDBV). Here, we perform genomic and structural analyses of 44 BDBV sequences, in...

Assessing residual bias in real-world vaccine effectiveness studies: validating negative controls to avoid misleading results

Observational studies and randomized controlled trials demonstrate that vaccines protect against infections and severe outcomes, but real-world vaccine effectiveness estimates remain vulnerable to residual biases. Negative control outcomes can help detect and mitigate such biases...

Immunotherapy-Related Cardiac Arrythmias: Incidence, Pathobiology, Risk Factors and Management

Abstract Purpose of Review Immunotherapies have revolutionized treatment strategies for cancer patients, improving the prognosis in many populations with advanced malignancies. Immune check point inhibitors (ICI) and Chimeric antigen receptor (CAR) T cell therapy are being increa...

Three Strategies to Strengthen Therapist Follow-Through in Therapy Sessions: Examination of Accountability in Clinical Supervision

Abstract Clinical supervision is a natural opportunity for promoting therapist use of clinical practices supported by research in community mental health services. However, the research on thespecific strategies in supervision that are likely to have a positive impact is limited....

Evaluating spectral unmixing techniques using imaging spectroscopy data for retrieval of green, non-photosynthetic vegetation, and soil fractional cover

Estimates of fractional cover of green vegetation (GV), non-photosynthetic vegetation (NPV), and soil provide valuable information about the Earth system. As the new generation of Earth visible-to-shortwave infrared (VSWIR) imaging spectrometers take orbit, global fractional cove...

Population coding under the scale invariance of high-dimensional noise

High-dimensional scale-invariant neural activity is ubiquitous across brain regions and species, but its implications for information coding remain unclear. Here, we ask how stimulus information in the high-dimensional activity of mouse V1 scales with neuron number: Does it satur...

Application to Dalhousie University September 2026 : A Quick Note About Information System Classifications

We have started an Application into The Dalhousie University English Program. We notice for the first time a very intelligent information system. Some documents that we did save in our Google Drive Account [but not published elsewhere*] have contributive value in the system. As f...

Distinct inflammatory marker profiles of adolescents and young adults among the HIV risk, infection, and treatment spectrum

Abstract Youth living with or at HIV-risk exhibit distinct immune perturbations during HIV exposure, infection, and antiretroviral therapy (ART). Understanding immune perturbations is critical for development of tailored prevention and enhanced therapeutic strategies. We performe...

Blindness After Facial Filler: An Alternative Theory

Facial fillers are widely regarded as a safe and effective method for cosmetic enhancement, with common adverse effects including bruising, swelling, and tenderness. Rarely, however, vascular complications can occur, resulting in severe outcomes such as sudden blindness. The clas...

Lamin B1 Coordinates the Assembly of the Nuclear Lamina

The nuclear lamina provides essential mechanical stability to protect the genome, yet how lamins target the nuclear rim and assemble into an organized meshwork remains unclear. To address this, we generated smooth muscle cells lacking all three lamin genes (“LKO cells”) and expre...