Stanford University

HMGA1 and HMGA2: epigenetic regulators in myeloproliferative neoplasms and novel platelet transcriptomic biomarkers of myelofibrosis

We read with great interest two recent studies by Handa et al. [ 1 ] and Bartalucci et al. [ 2 ] reporting novel chromosomal deletions within the 3’ untranslated region (UTR) of HMGA2 (Δ3’ HMGA2 ) in myeloproliferative neoplasms (MPNs). Both teams identified submicroscopic deleti...

A Multifunctional Composite Interface Layer toward High-Performance Stable Zn Anode

The development of aqueous zinc-ion batteries (AZIBs) is often limited by uncontrolled dendrite growth and detrimental side reactions occurring at the Zn anode. Herein, a multifunctional protective coating, constructed by incorporating vermiculite nanosheets (VN) into a carboxyme...

A User-Centered Approach to Customizing, Validating, and Evaluating a Large Language Model for Empowering Healthcare Providers with Up-to-Date Information on Adolescent and Child Health

Healthcare professionals (HCPs) in Kenya face critical challenges in accessing reliable, context-specific information on adolescent and child health, which hampers clinical decision-making and compromises patient outcomes. Large Language Models (LLMs) offer a promising solution b...

Severe Multifocal Cutaneous Sporotrichosis Caused by Sporothrix brasiliensis in People Living with HIV in Southern Brazil: Cases and Review

Background: Sporothrix brasiliensis-associated sporotrichosis is an emerging zoonotic mycosis in South America, especially in Brazil. Whereas sporotrichosis is classically described as a lymphangitic disease, multifocal forms occur, predominantly in people living with HIV (PLHIV)...

Radiofrequency Ablation for Papillary Thyroid Carcinoma versus Surgery and Other Thermal Ablation Techniques: A Systematic Review and Meta-Analysis of Outcomes

Background: Radiofrequency ablation (RFA) has been proposed for selected patients with low-risk papillary thyroid carcinoma (PTC). This study compared the effectiveness, safety, and procedural characteristics of RFA with those of surgery and other thermal ablation techniques. Met...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...

Efficacy and safety of tocilizumab for refractory postsurgical cystoid macular edema

Abstract Purpose Postsurgical CME is a common cause of suboptimal vision following both unremarkable cataract and vitreoretinal surgery. While there is no widely accepted treatment algorithm, therapeutic options include topical nonsteroidal anti-inflammatory drugs (NSAIDs), corti...

Climate-related health and sustainable healthcare activities of U.S. professional medical societies: a mixed-methods analysis

PURPOSE: The authors characterize how U.S. professional medical societies are addressing climate-related health impacts and sustainable healthcare practices, and identify barriers and priorities for advancing a climate-fit healthcare system. METHOD: Ninety-five U.S. medical socie...

Evaluation of Pre‐Operative Cartilage and Meniscus Ultrashort Echo Time T2 * as Biomarkers of Long‐Term Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction

ABSTRACT Background Ultrashort echo time T2* (UTE‐T2*) mapping is sensitive to the composition of deep cartilage and menisci. UTE‐T2* elevations are common after anterior cruciate ligament (ACL) injuries, but their long‐term prognostic importance is unknown. Hypothesis Higher pre...

PSHIC reveals allele-specific chromatin organization by phasing-free structural modeling

Resolving the distinct 3D chromatin architectures of parental chromosomes is critical for understanding diploid genome function, but many haplotype-resolved Hi-C contact-map methods remain constrained by their reliance on phased single-nucleotide polymorphisms (SNPs). This depend...

Cognitive appraisal processes mediate postinjury pain and disability: A longitudinal observational study.

PURPOSE/OBJECTIVE: Psychological appraisal processes of pain catastrophizing (PC) and perceived injustice (PI) are involved in the transition to postinjury disability. Although these factors are modifiable and may serve as ideal intervention targets to improve recovery, they have...

Differential contributions of β-tubulin isotypes to acentrosomal oocyte meiosis in C. elegans.

Oocyte meiotic spindles must achieve bipolarity and segregate chromosomes in the absence of centrosomes. Here, we use high-resolution immunofluorescence microscopy and live imaging to investigate the differential contributions of β-tubulin isotypes (TBB-1 and TBB-2) to assembly a...

Longitudinal Surgical Modeling of Early Glioblastoma Recurrence Reveals Emergence of Margin-Associated Neural Programs

Glioblastoma (GBM) is a lethal, treatment-resistant brain cancer characterized by diffuse brain invasion, complex neuron-glioma signaling, and cellular, molecular, and spatial heterogeneity. Surgery is the current mainstay of treatment, aimed at maximizing tumor cytoreduction, de...

Effect of a comic book-based educational intervention on human papillomavirus vaccine knowledge and safety perception among girls aged 9–14 in Nigeria

Background Cervical cancer is a leading cause of death for women and is preventable with the human papillomavirus (HPV) vaccine and regular screening. However, awareness of vaccines and screenings is poor in many low- and middle-income countries. In 2023, Nigeria sought to delive...

American Rhinologic Society Expert Practice Statement: Indications and Recommendations for Posterior Nasal Nerve Ablation

ABSTRACT The goal of this American Rhinologic Society expert practice statement (EPS) is to provide an evidence‐based evaluation of the current literature on posterior nasal nerve ablation. Subtopics reviewed include the evidence for specific indications such as nonallergic rhini...

Park Proximity and Emergency Department Visit Rates for Asthma and Acute Myocardial Infarction in Los Angeles County: A Cross-Sectional Ecological Study

BackgroundParks are promoted as a public health resource, and neighborhoods with limited park access often face cooccurring air pollution and socioeconomic disadvantage.The primary objective of this study was to estimate the association between census tract park proximity and eme...

How content sophistication shapes climate discourse on YouTube

We analyze 3163 climate-related YouTube videos posted between 2006 and 2021. More sophisticated videos—those with higher production quality, richer descriptions, longer duration, and specialized terminology—draw climate-related comments that lean toward explicit position-taking a...

Young children can infer what speakers know based on their causal influence over listeners

A causal, mentalistic understanding of communication—a process by which a speaker’s mind causes a change in a listener’s mind—can support powerful inferences that go beyond observable data. If A struggles to activate a toy but succeeds after B whispers to A, you can infer that B...

Localization and anticipation of seizure onset and propagation using network architecture of pathological high‐frequency oscillations

Abstract Objective In focal epilepsies, seizures originate from a presumed seizure onset zone (SOZ) and propagate through a network of dynamically interconnected brain regions. Accurate identification of the SOZ and propagation pathways is critical for surgical planning in patien...

Subverting Hebrew’s Gender Binary: Grammar, Poetry, and Performance in the Work of Esther Raab

This article examines antigrammaticality in the work of the so-called first “native” modern Hebrew poet, Esther Raab, focusing in particular on how Raab deploys the constraints of Hebrew’s highly gendered grammar in her poems. I begin by considering the broad implications of gram...