Stanford University

Survey Authentication Challenges During a Geriatrics Knowledge Assessment Pilot

ABSTRACT Background In this methodological Brief Report, we describe a multi‐institutional survey authentication challenge encountered during pilot deployment of the Age‐Friendly Knowledge Assessment Tool (AF‐KAT), a geriatrics knowledge assessment for graduating medical students...

Discussion: Educators leading change

The world is in crisis – again. Climate change, inequality, conflict and technology are sources of deep pain and anxiety. And around the world, too many politicians seem intent on deepening economic, environmental and social fault lines rather than healing them.We have been here...

Development and validation of a theoretical test for ultrasound-guided biopsy competence in the head and neck

PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...

Mapping pediatric cardiac troponin testing worldwide: results from the IFCC survey on emerging applications, standardization needs and access

OBJECTIVES: Limited guidance on the use and interpretation of cardiac troponin (cTn) testing in pediatric populations has restricted its broader adoption, despite the significant burden of congenital and acquired cardiac conditions in children. This survey aimed to evaluate globa...

Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study

Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...

What Does It Mean to Be Black? Experimental Evidence on the Situational Deployment of Racial Schemas

How do Black Americans construct narratives about the meaning and boundaries of Blackness in America today? We leverage an original, nationally representative survey experiment among U.S.-born Black Americans ( n = 3,100) to examine (1) justifications used to validate or reject a...

Adapting the MasSpec Pen for noninvasive detection of oral cavity squamous cell carcinoma

Oral Cavity Squamous Cell Carcinoma (OCSCC) is a common and deadly form of head and neck cancer which disproportionately afflicts low- and middle-income communities. Since the majority of OCSCC lesions are visible within the oral cavity, visual exam-guided biopsy remains the stan...

Effects of surface fluxes on the moist potential vorticity distribution in the axisymmetric tropical cyclone boundary layer

Abstract This study investigates the structure and dynamics of simulated tropical cyclone boundary layers (TCBLs) using a moist potential vorticity () framework. in the boundary layer of tropical cyclones is related to the distribution of equivalent potential temperature () and a...

The Six-Neuron Counterexample to the Target-Free Clique Conjecture Is Minimal

This record presents an exact, independently replayable computer-assisted proof that every legal combinatorial threshold-linear network (CTLN) on at most five neurons satisfies the algebraic target-free clique classification. Consequently, every nondegenerate legal CTLN on at mos...

Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk

PURPOSE OF REVIEW: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent complication of obesity and metabolic dysregulation, with limited therapies targeting upstream drivers of disease. Adipose tissue has emerged as a central regulator of...

OMVs of Pseudomonas aeruginosa extracted from chronic suppurative otitis media trigger ototoxicity: possible relation to activation of NLRP3 inflammasome

Abstract Background Chronic suppurative otitis media (CSOM) can lead to sensorineural hearing loss (SNHL), but the underlying mechanisms remain incompletely understood. This study aimed to investigate whether the outer membrane vesicles (OMVs) from Pseudomonas aeruginosa ( P.aeru...

Real-world use of large language models for mental health in 2024

The extent to which people use general-purpose large language models (LLMs) for their mental health is unknown. Information about use patterns is important for clinicians, developers, and regulators. We surveyed U.S. adults ( n = 1871) between August and October 2024 using strati...

Concessions and Protest Demobilization

How and why do concessions, or promises to implement reform in the future, affect protest mobilization in autocracies? Concessions are a routine response to protest and generate a puzzling empirical regularity: Although autocrats often renege once protest abates, concessions can...

RAS inhibition limits oncogenic signaling and tumorigenesis in neuroblastoma regardless of RAS mutational status

Abstract Neuroblastoma (NBL) is a rare and aggressive pediatric malignancy with a 5-year survival rate of 40–50% for patients diagnosed with high-risk disease. NBLs arise in the sympathetic nervous system and causes 11% of all pediatric cancer deaths. MYCN amplification or overex...

Isolation and genomic characterization of bacteriophage Luminis, a lytic Yuavirus infecting clinical strains of Pseudomonas aeruginosa

ABSTRACT We report the genome of Luminis, a lytic bacteriophage isolated from wastewater using Pseudomonas aeruginosa mPAO1Δpf4Δpf6. Phage Luminis is a Yuavirus with 61,617 bp of circularly permuted dsDNA and 64.4% GC content. In addition to reference strains, Luminis plaques on...

How well can off-the-shelf LLMs elucidate molecular structures from mass spectra using chain-of-thought reasoning?

Mass spectrometry (MS) is a powerful analytical technique for identifying small molecules, yet determining complete molecular structures directly from tandem mass spectra (MS/MS) remains a long-standing challenge due to complex fragmentation patterns and the vast diversity of che...

Geriatric Fall-Related Facial Fractures: A Nationwide Analysis of Epidemiology, Risk Factors, and Outcomes

INTRODUCTION: Falls are the leading cause of facial fractures in the elderly, contributing to significant morbidity and mortality. OBJECTIVES: This study aimed to identify the trends, epidemiology, characteristics, and outcomes of facial fractures in the elderly resulting from me...