Stanford University

A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer

PURPOSE: Immune checkpoint inhibitors have limited activity as monotherapy in biliary cancers. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic immune cell growth factor which achieved prolonged survival when combined with ipilimumab in melanoma. We cond...

Worked and Working Bones—Wild Resource Use in an Agricultural Neolithic Community at Miaodigou Site, China

This paper examines worked-bone production at the Miaodigou (MDG) site, a key Middle Neolithic settlement in northern China, to assess the role of bone objects in craft production, subsistence, and social life. During the expansion of millet agriculture and pig domestication, a s...

Deep Learning‐Based Enhancement of Already Diagnostic‐Quality MRI for Alzheimer's Disease Classification: Effects on Model Performance and Training Data Requirements

ABSTRACT Background Deep learning (DL)‐based image enhancement is widely used to improve suboptimal medical imaging. Whether it also benefits diagnostic‐quality MRI in downstream task performance and data‐efficiency remains unclear. Purpose To investigate the impact of DL‐based e...

The choice-wide behavioral association study: data-driven identification of interpretable behavioral components

Behavior contains rich structure across many timescales, but there is a dearth of methods to identify relevant components, especially over the longer periods required for learning and decision-making. Inspired by the goals and techniques of genome-wide association studies, we pre...

Fatal Neuroinvasive Astrovirus VA1 Encephalitis in a Child With High‐Risk B‐ALL Receiving Blinatumomab

O.L. is a named inventor on patents held by Boston Children's Hospital related to vaccine adjuvants and antigens as well as human in vitro systems that model the safety and immunogenicity of vaccines and immunotherapeutics. O.L.’s laboratory receives sponsored research support fr...

Synthesizing Colloidal Bimetallic Nanoparticles in Water Using a Dual‐Ligand Strategy

ABSTRACT Controlled aqueous synthesis of bimetallic nanoparticles below 5 nm remains challenging due to reduction potential mismatches between noble and base metals, which often causes uncontrolled aggregation. Here, we propose a dual‐ligand strategy to assist the commonly used s...

A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks

A century and a half of neuroscience has yielded many divergent theories of the neurobiology of language. Two factors that likely contribute to this situation include (a) conceptual disagreement about language and its component processes, and (b) intrinsic inter-individual variab...

Cranio-orbital craniotomy via an eyebrow incision for resection of anterior clinoid and tuberculum sella meningiomas

Abstract Background Anterior clinoid meningiomas (ACM) and tuberculum sella meningiomas (TSM) are anterior skull base tumors that commonly cause visual deterioration. The supraorbital keyhole approach may be used to resect these tumors but is limited by restricted intraoperative...

Emergency care use in early pregnancy and adverse maternal events at birth and up to 42 days postpartum among North Carolina Medicaid beneficiaries

Abstract Objective Emergency care (EC) utilization can indicate unmet medical or social needs. In pregnancy, EC use may identify individuals at risk for adverse outcomes and highlight opportunities for intervention. This study examined the association between EC use in early preg...

Bias in Cohort Studies: The Critical Importance of the “Why” and “When” of Treatment Decisions

When it comes to high-quality, rigorous research, children generally get the short end of the stick. Randomized controlled trials (RCTs)—the “gold standard” for clinical research1—are rare in this population.2 RCTs are expensive, time-consuming, and often fraught with ethical con...

Time-resolved imaging of antiferromagnetic skyrmion interactions

Abstract Quantifying particle interactions is central to understanding and controlling collective dynamics in particle-based devices such as those comprising skyrmion ensembles. Here we directly visualize, in real time, the nanosecond current-driven dynamics of an antiferromagnet...

Self‐Growing Conductive Hydrogels Establish Volumetric Biointerfaces for Cardiac Conduction Restoration

ABSTRACT Restoring three‐dimensional electrical conduction in infarcted myocardium remains a critical challenge, as conventional conductive hydrogel patches largely remain surface‐confined and prevent electrical coupling of residual cardiomyocytes within fibrotic scars. Here, we...

The Biomimetic Sampler: A Constraint-Based Ideation Exercise for Introductory Biodesign Education

Abstract This demo presents the Biomimetic Sampler: a constraint-based ideation exercise that introduces participants to foundational concepts of biodesign through two linked activities, observation and translation, conducted under time pressure. The exercise requires no prior ba...

Grinding en route to sedentism: Plant processing in the 8 ka-BP southern Mongolian Plateau, China

Plant food exploitation has long been considered one of the most significant windows to understanding the process of sedentism. Two early Neolithic sites, Yumin (ca. 8,400-7,600 cal BP) and Simagou (ca. 7,500-7,000 cal BP), witnessed the earliest onset of a sedentary lifeway in t...

An Intrinsic Formula for the Ray–West Correction Term

For a nonempty permutation β of length m, Ray and West expressed the number of length-(m+2) permutations containing β using a correction term j(β), but did not give j as a statistic intrinsic to β. This is Problem 3.7 of Vatter’s 2026 survey. This preliminary technical report pro...

Solvent-Mediated Diffusion Enables Directed Functionalization of Polymer Semiconductor Interfaces

The increasing interest in the development of intrinsically stretchable electronic devices based on polymer semiconductors (PSCs) necessitates a comprehensive understanding of the interfacial chemistry of these PSC films, alongside facile processing methods to modify these proper...

An Intrinsic Formula for the Ray–West Correction Term

For a nonempty permutation β of length m, Ray and West expressed the number of length-(m+2) permutations containing β using a correction term j(β), but did not give j as a statistic intrinsic to β. This is Problem 3.7 of Vatter’s 2026 survey. This preliminary technical report pro...

Price comparisons for the leading brands of oral nicotine pouches and cigarettes

Abstract Background and aims United States (US) sales of oral nicotine pouches (ONPs) more than tripled from 2021 to 2024, with Zyn brand consistently the market leader. To understand the relative price of ONPs and cigarettes, this study answers three questions about differences...

Trions as Fundamental Species in Chemically Doped Polymer Semiconductors

Doping is a cornerstone strategy for enhancing charge transport in semiconducting polymers, important for their application in, for example, semi-transparent electrode materials, thermoelectric devices, and antistatic coatings. Both chemical and electrochemical doping have, for t...

Robust Inference With Ghostknockoffs in Genome‐Wide Association Studies With Sample Relatedness

ABSTRACT Genome‐wide association studies (GWASs) have been extensively adopted to depict the underlying genetic architecture of complex traits. Recent studies show that knockoff‐based methods can identify variants with unique, potentially causal effects on phenotypes. However, th...