Stanford University

Enhanced Osteoinduction, Rheological and Mechanical Performance of 3D-Printed Methylcellulose-Gelatin-Hydroxyapatite Scaffolds

Complex patient-specific bone defects remain difficult to reconstruct because the regenerative capacity of bone is limited and prefabricated implants cannot readily match defect geometry. In this work, methylcellulose-gelatin-hydroxyapatite (MC/GEL/HA) inks were formulated with v...

Sensitivity-Driven Adaptive Surrogate Modeling for Simulation and Optimization of Dynamical Systems

Abstract. This paper develops a surrogate model refinement approach for the simulation of dynamical systems and the solution of optimization problems governed by dynamical systems in which surrogates replace expensive-to-compute state- and control-dependent component functions in...

Towards an Asian registry of wrongful convictions

Wrongful convictions represent a persistent yet unevenly documented problem across Asian criminal justice systems. While international research has identified common factors contributing to known wrongful convictions, systematic information about wrongful conviction cases in Asia...

Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression

ABSTRACT Objective Stanford Neuromodulation Therapy (SNT) has demonstrated impressive efficacy for treatment-resistant depression (TRD), but its neurophysiological mechanisms remain poorly understood. This study investigated the neurophysiological correlates of SNT using transcra...

A genomic catalog of Earth’s bacterial and archaeal symbionts

1 SUMMARY Microbial symbiosis drives the functional and phylogenomic diversification of life on Earth, yet remains underexplored due to culturing challenges. This study employed machine learning (ML) to predict symbiotic lifestyles in hundreds of thousands of microbial genomes fr...

Subicular spatial codes arise from predictive mapping

Abstract The successor representation has emerged as a powerful model for understanding mammalian navigation and memory; explaining the spatial coding properties of hippocampal place cells and entorhinal grid cells. However, the diverse spatial responses of subicular neurons, the...

Functional fractionation of large-scale brain networks in the human subcortex

Brain network mapping plays a crucial role in advancing our understanding of human brain organization and the neuroanatomic foundations of cognition. Historically, the identification of large-scale brain networks has focused on the cerebral cortex. Some cortical networks have bee...

Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity

Long-range white matter (WM) tracts support cognition by enabling communication between distant cortical regions, which are organized along a hierarchy defined by the sensorimotor-to-association (S-A) axis. However, it remains unknown how WM tracts are positioned within the corti...

MSP4BIO Deliverable 3.4: Ecological toolkit (ESE1) for MPAs prioritization and networking

The Ecological Toolkit (ESE1) was developed to support the design, establishment and management of Marine Protected Areas (MPAs) by improving decision-making processes, focusing on prioritisation of areas, integration of connectivity processes and assessment of human impacts on m...

MSP4BIO Deliverable 3.4: Ecological toolkit (ESE1) for MPAs prioritization and networking

The Ecological Toolkit (ESE1) was developed to support the design, establishment and management of Marine Protected Areas (MPAs) by improving decision-making processes, focusing on prioritisation of areas, integration of connectivity processes and assessment of human impacts on m...

Free-Placement Optimization of Ground Station Locations for Low-Earth-Orbit Satellites

Rapidly expanding low-Earth-orbit satellite constellations are placing increasing demands on terrestrial ground networks, motivating the development of more efficient ground station network designs. Current approaches select sites from predefined locations, limiting optimization...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence

Importance Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems routinely use outreach to promote preventive care, most strategies are static and lack evidence from randomized clinical trials. Objective To determine wh...

Modeling and Design Optimization of Looped Water Distribution Networks using MS Excel: Developing the Open-Source X-WHAT Model

Abstract Cost-effective water distribution network (WDN) design is crucial for reliable urban water supply. This paper introduces the open-source Excel for Water system Hydraulic Analysis Tool (X-WHAT) for WDN simulation and preliminary design. Unlike traditional spreadsheet appr...

Incidence, risk factors, and prognostic implications of hospitalizations for heart failure among patients with myeloproliferative neoplasms

Myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), are a group of chronic leukemias associated with increased risk of heart failure (HF). Despite a link between MPNs and HF, prognostic implications and ri...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

A Vershik–Kerov theorem for wreath products

Let G_{n,k} be the group of permutations of \{1,2,\ldots, kn\} that permutes the first k symbols arbitrarily, then the next k symbols and so on through the last k symbols. Finally, the n blocks of size k are permuted in an arbitrary way. For \sigma chosen uniformly in G_{n,k} , l...

A suite of eight Toxoplasma gondii effectors cooperates to activate the non-canonical NF-κB pathway

ABSTRACT As a master of host-cell reprogramming, Toxoplasma gondii ( T. gondii ) tachyzoites manipulate diverse signaling networks to establish a niche permissive for long-term infection. While the parasite’s subversion of canonical NF-κB signaling (p65/p50) is well established,...

Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces

Natural Killer(NK) cells eliminate target cells through antibody-dependent cell-mediated cytotoxicity(ADCC), initiated by CD16a(FcγRIIIa) recognizing the Fc region of antibodies bound to the target cell surface. While the recognition is considered to be driven by CD16a-Fc binding...

Resection Margin Status, Recurrence Pattern, and Salvageability After Resection for Colorectal Liver Metastases

Abstract Background The prognostic significance of margin status after colorectal liver metastases (CRLM) resection remains debated in the era of effective systemic therapy. This study examined the prognostic meaning of microscopically positive (R1) margins, focusing on recurrenc...